General Information of the Protein
Protein ID
PT03838
Protein Name
Proteasome subunit beta type-9
Secondarily
Protein Name
Low molecular mass protein 2
Macropain chain 7
Multicatalytic endopeptidase complex chain 7
Proteasome chain 7
Proteasome subunit beta-1i
Really interesting new gene 12 protein
Gene Name
PSMB9
Secondarily
Gene Name
LMP2
PSMB6i
RING12
Sequence
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Protease
>
Threonine protease
>
Threonine protease PBT clan
>
Threonine protease T1B subfamily
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
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Uniprot ID
Primary ID:
P28065

Secondarily ID:
B0V0T1
Q16523
Q5JNW4
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Ensembl ID
ENSG00000240065
HGNC ID
HGNC:9546
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000116 , MOLT-4
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0213895
 Compound Info 
Kzr-616
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C30H42N4O8
  1
1
IC50 = 131 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0151829
 Compound Info 
(2S)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C30H42N4O7
  1
1
IC50 = 223 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0062987
 Compound Info 
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H40N4O7
  1
1
IC50 = 287 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0086566
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C35H48N4O5
  1
1
IC50 = 415 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0086565
 Compound Info 
CHEMBL4441524
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C31H43N3O7
  1
1
IC50 = 1850 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0847941
 Compound Info 
N-((R)-1-((S)-3-(1H-indol-3-yl)-1-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-ylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)-3-methyl-1H-indene-2-carboxamide
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C37H38N4O5
  1
1
IC50 = 2210 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0403175
 Compound Info 
CHEMBL4454809
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C32H41N3O7
  1
1
IC50 = 3530 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0098995
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-4-(4-methylphenyl)-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C37H52N4O5
  1
1
IC50 > 25000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000174 , Raji
 Cell Line Info 
Cell Line ID: CL000186 , RPMI-8226
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0213895
 Compound Info 
Kzr-616
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C30H42N4O8
  1
1 IC50 = 0.623 nM
CP0351150
 Compound Info 
(14S,17S)-N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-2,5,16-trioxo-12-oxa-1,4,15-triazabicyclo[15.3.0]icosane-14-carboxamide
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C26H42N4O7
  1
1 IC50 = 65.6 nM
CP0576199
 Compound Info 
(13S,16S)-N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-2,5,15-trioxo-11-oxa-1,4,14-triazabicyclo[14.3.0]nonadecane-13-carboxamide
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C25H40N4O7
  1
1 IC50 = 69.4 nM
CP0075994
 Compound Info 
(2S)-1-(2-acetamidoacetyl)-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
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C27H38N4O6
  2
1 IC50 = 102.98 nM
2 IC50 = 105.2 nM
CP0576198
 Compound Info 
(3S,6S)-N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-5,11-dioxo-19-oxa-4,10-diazatricyclo[18.2.2.06,10]tetracosa-1(23),20(24),21-triene-3-carboxamide
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C31H45N3O6
  1
1 IC50 = 129.3 nM
CP0411616
 Compound Info 
N-[(2S)-1-[[(2S)-1-[(2S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]heptanamide
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C25H48N2O5Si
  1
1 IC50 = 140 nM
CP0958942
 Compound Info 
N-((2S)-3-hydroxy-1-((2S)-1-hydroxy-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-2-ylamino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide
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C21H25N3O6
  1
1 IC50 = 157.9 nM
CP0418920
 Compound Info 
(3S,6S)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-5,11-dioxo-19-oxa-4,10-diazatricyclo[18.2.2.06,10]tetracosa-1(23),20(24),21-triene-3-carboxamide
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C34H43N3O6
  1
1 IC50 = 184.1 nM
CP0151829
 Compound Info 
(2S)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C30H42N4O7
  1
1 IC50 = 223 nM
CP0573254
 Compound Info 
(10S,13S)-N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-2,12-dioxo-8-oxa-1,11-diazabicyclo[11.3.0]hexadecane-10-carboxamide
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C23H37N3O6
  1
1 IC50 = 412.8 nM
CP0086566
 Compound Info 
(2S)-2-[[2-(azepan-1-yl)acetyl]amino]-4-methyl-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanamide
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C35H48N4O5
  1
1 IC50 = 425 nM
CP0062987
 Compound Info 
(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide
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C31H40N4O7
  3
1 IC50 = 590 nM
2 IC50 = 1009 nM
3 IC50 = 4273 nM
CP0086565
 Compound Info 
CHEMBL4441524
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C31H43N3O7
  1
1 IC50 = 1850 nM
Clinical Information about the Protein
Target 1 ( Proteasome beta-9 (PS beta-9) )
Target Type Patented-recorded Target