General Information of the Compound
Compound ID
CP0570106
Compound Name
US10294246, Compound No. 20
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Structure
Formula
C16H16BN3O4
Molecular Weight
325.133
Canonical SMILES
OB(O)[C@H](Cc1coc2ccccc12)NC(=O)Cc1ncccn1
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InChI
InChI=1S/C16H16BN3O4/c21-16(9-15-18-6-3-7-19-15)20-14(17(22)23)8-11-10-24-13-5-2-1-4-12(11)13/h1-7,10,14,22-23H,8-9H2,(H,20,21)/t14-/m0/s1
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InChIKey
CVSVLKJLLAPSRC-AWEZNQCLSA-N
Physicochemical Property
logP
0.5048
Rotatable Bonds
6
Heavy Atom Count
24
Polar Areas
108.48
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 140861690
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02585, Proteasome subunit beta type-5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 204 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 230 nM
Protein ID: PT03168, Proteasome subunit beta type-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000752 PBMC iPSC #1 Homo sapiens (Human)  1
1
IC50 = 15.5 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.3 nM