General Information of the Compound
Compound ID
CP0574852
Compound Name
(2S)-N'-tert-butyl-N-[(2S)-1-[(4-fluoronaphthalen-1-yl)methylamino]-1-oxopropan-2-yl]-2-(3-phenylpropanoylamino)pentanediamide
    Show/Hide
Formula
C32H39FN4O4
Molecular Weight
562.686
Canonical SMILES
C[C@H](NC(=O)[C@H](CCC(=O)NC(C)(C)C)NC(=O)CCc1ccccc1)C(=O)NCc1ccc(F)c2ccccc12
    Show/Hide
InChI
InChI=1S/C32H39FN4O4/c1-21(30(40)34-20-23-15-16-26(33)25-13-9-8-12-24(23)25)35-31(41)27(17-19-29(39)37-32(2,3)4)36-28(38)18-14-22-10-6-5-7-11-22/h5-13,15-16,21,27H,14,17-20H2,1-4H3,(H,34,40)(H,35,41)(H,36,38)(H,37,39)/t21-,27-/m0/s1
    Show/Hide
InChIKey
LEKFHXQPKLJWJC-IDISGSTGSA-N
Physicochemical Property
logP
3.9123
Rotatable Bonds
12
Heavy Atom Count
41
Polar Areas
116.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL4758484
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02585, Proteasome subunit beta type-5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 2031 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 244 nM
Protein ID: PT03168, Proteasome subunit beta type-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000626 Karpas-1106P Homo sapiens (Human)  1
1
IC50 = 39 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.6 nM