General Information of the Protein
Protein ID
PT01946
Protein Name
Histone deacetylase 9
Secondarily
Protein Name
Histone deacetylase 7B
Histone deacetylase-related protein
MEF2-interacting transcription repressor MITR
Gene Name
HDAC9
Secondarily
Gene Name
HDAC7
HDAC7B
HDRP
KIAA0744
MITR
Sequence
MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS
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Organism
Homo sapiens, Human
Protein Classification
Epigenetic regulator
>
Eraser
>
Histone deacetylase
>
HDAC class IIa
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.
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Uniprot ID
Primary ID:
Q9UKV0

Secondarily ID:
A7E2F3
B7Z4I4
B7Z917
B7Z928
B7Z940
C9JS87
E7EX34
F8W9E0
O94845
O95028
Q2M2R6
Q86SL1
Q86US3
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Ensembl ID
ENSG00000048052
HGNC ID
HGNC:14065
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000314 , HEK293T/17
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0057110
 Compound Info 
4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
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C19H23N3O3
  1
1
IC50 = 2000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0431647
 Compound Info 
3,4-dichloro-N-[[4-(hydroxycarbamoyl)phenyl]methyl]benzamide
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C15H12Cl2N2O3
  1
1
IC50 = 3070 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0431646
 Compound Info 
5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-1,2-oxazole-3-carboxamide
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C13H11Cl2N3O4
  1
1
IC50 = 38200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0004988
 Compound Info 
pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
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C21H20N4O3
  2
1 IC50 = 0.5 nM
2 IC50 > 100000 nM
CP0003580
 Compound Info 
Faridak
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C21H23N3O2
  6
1 IC50 = 5.7 nM
2 IC50 = 888 nM
3 IC50 = 922.2 nM
4 Ki = 1.2 nM
5 Ki = 830 nM
6 Ki = 3200 nM
CP0005479
 Compound Info 
CHEBI:46024
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C17H22N2O3
  9
1 IC50 = 20 nM
2 IC50 = 20.1 nM
3 IC50 = 38 nM
4 IC50 = 38.1 nM
5 IC50 = 38.12 nM
6 IC50 = 70.1 nM
7 IC50 = 4920 nM
8 IC50 = 5000 nM
9 Ki = 800 nM
CP0003832
 Compound Info 
N'-hydroxy-N-phenyloctanediamide
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C14H20N2O3
  20
1 IC50 = 20 nM
2 IC50 = 38 nM
3 IC50 = 107.2 nM
4 IC50 = 200 nM
5 IC50 = 316 nM
6 IC50 = 320 nM
7 IC50 = 3570 nM
8 IC50 = 7372.8 nM
9 IC50 = 22800 nM
10 IC50 = 49000 nM
11 IC50 = 51290 nM
12 IC50 = 64000 nM
13 IC50 = 80030 nM
14 IC50 > 5000 nM
15 IC50 > 10000 nM
16 IC50 > 33000 nM
17 IC50 > 33330 nM
18 Ki = 49 nM
19 Ki = 65 nM
20 Ki = 2000 nM
CP0033005
 Compound Info 
2-(2-fluorophenyl)-N-hydroxy-2-[4-[5-(trifluoromethyl)pyrimidin-2-yl]phenyl]acetamide
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C19H13F4N3O2
  1
1 IC50 = 50 nM
CP0124688
 Compound Info 
N-hydroxy-9H-fluorene-9-carboxamide
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C14H11NO2
  1
1 IC50 = 120 nM
CP0066173
 Compound Info 
N-hydroxy-2,2-diphenylacetamide
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C14H13NO2
  1
1 IC50 = 510 nM
CP0003676
 Compound Info 
N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide
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C23H24N8O4S
  1
1 IC50 = 554 nM
CP0057110
 Compound Info 
4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
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C19H23N3O3
  1
1 IC50 = 6720 nM
CP0015005
 Compound Info 
S-[(E)-4-[(4Z,7S,10S)-4-ethylidene-2,5,8,12-tetraoxo-7-propan-2-yl-9-oxa-16-thia-3,6,13,18-tetrazabicyclo[13.2.1]octadeca-1(17),15(18)-dien-10-yl]but-3-enyl] octanethioate
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C29H42N4O6S2
  1
1 IC50 > 10000 nM
CP0008777
 Compound Info 
JNJ-26481585
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C21H26N6O2
  2
1 Ki = 3.8 nM
2 Ki = 5.3 nM
CP0013235
 Compound Info 
(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide
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C20H32Cl2N4O2
  1
1 Ki = 24 nM
CP0013905
 Compound Info 
[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
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C24H27N3O4
  1
1 Ki = 390 nM
Clinical Information about the Protein
Target 1 ( Histone deacetylase 9 (HDAC9) )
Target Type Patented-recorded Target