General Information of the Protein
Protein ID
PT00285
Protein Name
Histone deacetylase
Gene Name
HDAC1
Sequence
MSNRKKVAYFHDPDIGSYYYGAGHPMKPQRIRMTHSLIVSYNLYKYMEVYRPHKSDVNELTLFHDYEYIDFLSSISLENYREFTYQLKRFNVGEATDCPVFDGLFQFQQSCAGASIDGASKLNHHCADICVNWSGGLHHAKMSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKFGDYFPGTGDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFKVVIDKCVQTYRPGAIIIQCGADSLTGDRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGGYTIRNVSRCWAYETGVVLNKHHEMPDQISLNDYYDYYAPDFQLHLQPSNIPNYNSPEHLSRIKMKIAENLRHIEHAPGVQFSYVPPDFFNSDIDDESDKNQYELKDDSGGGRAPGTRAKEHSTTHHLRRKNYDDDFFDLSDRDQSIVPY
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Organism
Plasmodium falciparum, malaria parasite P. falciparum
Protein Classification
Epigenetic regulator
>
Eraser
>
Histone deacetylase
>
HDAC class I
Uniprot ID
Q9XYC7
Ensembl ID
ENSG00000116478
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000090 , Schneider 2
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0005479
 Compound Info 
CHEBI:46024
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C17H22N2O3
  1
1
IC50 = 0.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0009029
 Compound Info 
(6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H-indol-3-ylmethyl)-12-(6-oxo-octyl)-decahydro-4a,7,10,13-tetraaza-benzocyclododecene-5,8,11,14-tetraone
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C34H49N5O6
  1
1
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0003580
 Compound Info 
Faridak
   Show/Hide
C21H23N3O2
  1
1
IC50 = 1.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0939842
 Compound Info 
7-(2-(4-(1H-imidazol-1-yl)styryl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C18H23N5O3
  1
1
IC50 = 15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0897128
 Compound Info 
7-(2-(2-(6-bromobenzo[d][1,3]dioxol-5-yl)vinyl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C16H20BrN3O5
  1
1
IC50 = 20 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0897129
 Compound Info 
7-(2-(2-bromo-5-methoxystyryl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C16H22BrN3O4
  1
1
IC50 = 22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0897130
 Compound Info 
7-(2-(2-(2-bromopyridin-3-yl)vinyl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C14H19BrN4O3
  1
1
IC50 = 36 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0880092
 Compound Info 
7-(2-(2-bromostyryl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C15H20BrN3O3
  1
1
IC50 = 37 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0921899
 Compound Info 
7-(2-(4-(dimethylamino)-2-hydroxystyryl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C17H26N4O4
  1
1
IC50 = 37 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0921919
 Compound Info 
N-hydroxy-7-(2-(2-(2-hydroxynaphthalen-1-yl)vinyl)hydrazinyl)-7-oxoheptanamide
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C19H23N3O4
  1
1
IC50 = 41 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0880091
 Compound Info 
N-hydroxy-8-oxo-8-(2-(2,4,6-trihydroxystyryl)hydrazinyl)octanamide
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C16H23N3O6
  1
1
IC50 = 43 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0870634
 Compound Info 
6-(2-(4-bromostyryl)hydrazinyl)-N-hydroxy-6-oxohexanamide
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C14H18BrN3O3
  1
1
IC50 = 45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0955017
 Compound Info 
7-(2-(2-bromo-5-hydroxystyryl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C15H20BrN3O4
  1
1
IC50 = 49 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0003832
 Compound Info 
N'-hydroxy-N-phenyloctanediamide
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C14H20N2O3
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0880090
 Compound Info 
N-hydroxy-7-(2-(3-hydroxystyryl)hydrazinyl)-7-oxoheptanamide
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C15H21N3O4
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0941757
 Compound Info 
7-(2-(2-bromo-4-hydroxy-5-methoxystyryl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C16H22BrN3O5
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0955019
 Compound Info 
6-(2-(2-bromo-4-hydroxy-5-methoxystyryl)hydrazinyl)-N-hydroxy-6-oxohexanamide
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C15H20BrN3O5
  1
1
IC50 = 59 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0943600
 Compound Info 
6-(2-(2-bromo-5-hydroxystyryl)hydrazinyl)-N-hydroxy-6-oxohexanamide
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C14H18BrN3O4
  1
1
IC50 = 89 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0955018
 Compound Info 
7-(2-(2-chlorostyryl)hydrazinyl)-N-hydroxy-7-oxoheptanamide
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C15H20ClN3O3
  1
1
IC50 = 90 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0939814
 Compound Info 
6-(2-(2-bromo-4-hydroxystyryl)hydrazinyl)-N-hydroxy-6-oxohexanamide
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C14H18BrN3O4
  1
1
IC50 = 106 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0955016
 Compound Info 
8-(2-(2,5-dihydroxystyryl)hydrazinyl)-N-hydroxy-8-oxooctanamide
   Show/Hide
C16H23N3O5
  1
1
IC50 = 110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0004988
 Compound Info 
pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
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C21H20N4O3
  1
1
IC50 = 940 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0020977
 Compound Info 
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
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C13H10O2
  1
1
IC50 > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0076185
 Compound Info 
(S)-6-acetamido-2-(2-((S)-2-acetamido-4-methylpentanamido)acetamido)-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide, 3
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C28H39N5O7
  1
1
Km = 30000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0003580
 Compound Info 
Faridak
   Show/Hide
C21H23N3O2
  1
1 IC50 = 3.3 nM
CP0003832
 Compound Info 
N'-hydroxy-N-phenyloctanediamide
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C14H20N2O3
  1
1 IC50 = 130 nM
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00169 Histone deacetylase Cryptosporidium parvum
 Protein Info