General Information of the Cell Line
Cell Line ID
CL000591
Cell Line Name
HCT 15
Synonyms
HCT-15
HCT.15
HCT15
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0292
Disease
Colon adenocarcinoma (NCIt: C4349)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT05157, Acetyl-coenzyme A synthetase, cytoplasmic
 Protein Info 
Compound ID Compound Name Compound Formula
CP0189763
 Compound Info 
6-chloro-3-ethyl-N-(1-ethyl-1,2,4-triazol-3-yl)-2-[hydroxy(diphenyl)methyl]pyrazolo[1,5-a]pyridine-5-carboxamide
   Show/Hide
C27H25ClN6O2
  1
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0517082
 Compound Info 
1-ethyl-N-(1-ethyl-1,2,4-triazol-3-yl)-2-[hydroxy(dithiophen-2-yl)methyl]-5-methoxyimidazo[4,5-b]pyridine-6-carboxamide
   Show/Hide
C23H23N7O3S2
  1
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0517390
 Compound Info 
1-ethyl-N-(4-ethyl-1,3-oxazol-2-yl)-2-[hydroxy(diphenyl)methyl]-5-methoxyimidazo[4,5-b]pyridine-6-carboxamide
   Show/Hide
C28H27N5O4
  1
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0570107
 Compound Info 
2-[bis(2-fluorophenyl)-hydroxymethyl]-1-ethyl-N-(1-ethyl-1,2,4-triazol-3-yl)-5-methoxyimidazo[4,5-b]pyridine-6-carboxamide
   Show/Hide
C27H25F2N7O3
  2
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0576180
 Compound Info 
1-ethyl-N-(5-ethyl-1,3-oxazol-2-yl)-2-[hydroxy(diphenyl)methyl]-5-methoxyimidazo[4,5-b]pyridine-6-carboxamide
   Show/Hide
C28H27N5O4
  2
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0444744
 Compound Info 
2-[[4-(difluoromethoxy)phenyl]-(2-fluorophenyl)-hydroxymethyl]-1-ethyl-N-(1-ethyl-1,2,4-triazol-3-yl)-5-methoxyimidazo[4,5-b]pyridine-6-carboxamide
   Show/Hide
C28H26F3N7O4
  2
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0554493
 Compound Info 
[1-ethyl-5-methoxy-6-(2H-tetrazol-5-yl)imidazo[4,5-b]pyridin-2-yl]-bis(2-fluorophenyl)methanol
   Show/Hide
C23H19F2N7O2
  2
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0558093
 Compound Info 
[1-ethyl-5-methoxy-6-(2H-tetrazol-5-yl)imidazo[4,5-b]pyridin-2-yl]-diphenylmethanol
   Show/Hide
C23H21N7O2
  1
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0951779
 Compound Info 
(1-ethyl-5-methoxy-6-(1H-tetrazol-5-yl)-1H-imidazo[4,5-b]pyridin-2-yl)(phenyl)(thiazol-2-yl)methanol
   Show/Hide
C20H18N8O2S
  2
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0965380
 Compound Info 
(1-ethyl-5-methoxy-6-(1H-tetrazol-5-yl)-1H-imidazo[4,5-b]pyridin-2-yl)(phenyl)(pyridin-2-yl)methanol
   Show/Hide
C22H20N8O2
  1
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0969470
 Compound Info 
(1-ethyl-5-methoxy-6-(1H-tetrazol-5-yl)-1H-imidazo[4,5-b]pyridin-2-yl)(phenyl)(thiophen-2-yl)methanol
   Show/Hide
C21H19N7O2S
  2
1
IC50 = 0.01 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0951780
 Compound Info 
(1-ethyl-5-methoxy-6-(1H-tetrazol-5-yl)-1H-imidazo[4,5-b]pyridin-2-yl)(phenyl)(pyrimidin-2-yl)methanol
   Show/Hide
C21H19N9O2
  1
1
IC50 = 1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT04124, Proteinase-activated receptor 2
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0003433
 Compound Info 
(Arylindolyl)maleimide deriv. 27
   Show/Hide
 C21H16N4O2  1
1
GI50 = 3490 nM
   TI
   LI
   LO
   TS
CP0003832
 Compound Info 
N'-hydroxy-N-phenyloctanediamide
   Show/Hide
 C14H20N2O3  1
1
IC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0006369
 Compound Info 
6-[3-[4-[1-(5-cyanopentyl)indol-3-yl]-1-hydroxy-2,5-dioxopyrrol-3-yl]indol-1-yl]hexanenitrile
   Show/Hide
 C32H31N5O3  1
1
LC50 > 100000 nM
   TI
   LI
   LO
   TS
CP0010714
 Compound Info 
N-[4-chloro-3-(trifluoromethyl)phenyl]-5-[3-(4-methylpiperazin-1-yl)propoxy]quinolin-2-amine
   Show/Hide
 C24H26ClF3N4O  1
1
GI50 = 1220 nM
   TI
   LI
   LO
   TS
CP0075213
 Compound Info 
2-[3-[5-bromo-2-[4-[(3S)-3,4-dimethylpiperazin-1-yl]-3-methoxyanilino]pyrimidin-4-yl]phenyl]acetonitrile
   Show/Hide
 C25H27BrN6O  1
1
EC50 = 590 nM
   TI
   LI
   LO
   TS
CP0082019
 Compound Info 
(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
   Show/Hide
 C22H21NO2S  1
1
GI50 = 2510 nM
   TI
   LI
   LO
   TS
CP0085832
 Compound Info 
(1R,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
   Show/Hide
 C24H36N4O6S2  1
1
GI50 = 450 nM
   TI
   LI
   LO
   TS
CP0148456
 Compound Info 
(2R)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropan-1-ol
   Show/Hide
 C23H25NO2S  1
1
GI50 = 210 nM
   TI
   LI
   LO
   TS
CP0176598
 Compound Info 
N-[4-[2-[(2S,3S,5R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide
   Show/Hide
 C34H52N4O7S2Si  1
1
GI50 = 3548.13 nM
   TI
   LI
   LO
   TS
CP0185310
 Compound Info 
(E)-N-hydroxy-3-[3-(1H-indole-2-carbonyl)phenyl]prop-2-enamide
   Show/Hide
 C18H14N2O3  1
1
IC50 = 770 nM
   TI
   LI
   LO
   TS
CP0408582
 Compound Info 
1-[3-[4-[1-adamantyl(phenyl)methyl]phenyl]propyl]piperazine
   Show/Hide
 C30H40N2  1
1
GI50 = 3.15 nM
   TI
   LI
   LO
   TS
CP0439788
 Compound Info 
3-Bromo-9,9-dimethyl-5,6,8,9,10,11-hexahydro-12Hazepino[ 3',4':4,5]pyrrolo[2,1-a]isoquinolin-12-one
   Show/Hide
 C18H19BrN2O  1
1
IC50 = 25580 nM
   TI
   LI
   LO
   TS
CP0452777
 Compound Info 
1-[3-[4-[1-adamantyl(phenyl)methyl]phenyl]propyl]-4-methylpiperazine
   Show/Hide
 C31H42N2  1
1
GI50 = 3.5 nM
   TI
   LI
   LO
   TS
CP0503503
 Compound Info 
9,9-Dimethyl-3-nitro-5,6,8,9,10,11-hexahydro-12H-azepino[ 3',4':4,5]pyrrolo[2,1-a]isoquinolin-12-one
   Show/Hide
 C18H19N3O3  1
1
IC50 = 29500 nM
   TI
   LI
   LO
   TS
CP0517268
 Compound Info 
1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-ethylpiperazine
   Show/Hide
 C29H38N2  1
1
LC50 = 100000 nM
   TI
   LI
   LO
   TS
CP0517983
 Compound Info 
N-[4-[2-[(2S,3S,5S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1,3-dithian-2-yl]phenyl]-N'-hydroxyoctanediamide
   Show/Hide
 C34H52N4O7S2Si  1
1
GI50 = 15488.17 nM
   TI
   LI
   LO
   TS
CP0557086
 Compound Info 
(1S,7S,10S,16E,21R)-7-benzyl-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
   Show/Hide
 C26H34N4O6S2  1
1
GI50 = 26000 nM
   TI
   LI
   LO
   TS
CP0558284
 Compound Info 
(1S,7R,10S,16E,21R)-7-(2-methylpropyl)-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
   Show/Hide
 C23H36N4O6S2  1
1
GI50 = 590 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line