General Information of the Compound
Compound ID
CP0444744
Compound Name
2-[[4-(difluoromethoxy)phenyl]-(2-fluorophenyl)-hydroxymethyl]-1-ethyl-N-(1-ethyl-1,2,4-triazol-3-yl)-5-methoxyimidazo[4,5-b]pyridine-6-carboxamide
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Formula
C28H26F3N7O4
Molecular Weight
581.555
Canonical SMILES
CCn1cnc(NC(=O)c2cc3n(CC)c(nc3nc2OC)C(O)(c2ccc(OC(F)F)cc2)c2ccccc2F)n1
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InChI
InChI=1S/C28H26F3N7O4/c1-4-37-15-32-27(36-37)35-23(39)18-14-21-22(33-24(18)41-3)34-25(38(21)5-2)28(40,19-8-6-7-9-20(19)29)16-10-12-17(13-11-16)42-26(30)31/h6-15,26,40H,4-5H2,1-3H3,(H,35,36,39)
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InChIKey
FBWCQYAZODUEFO-UHFFFAOYSA-N
Physicochemical Property
logP
4.3482
Rotatable Bonds
10
Heavy Atom Count
42
Polar Areas
129.21
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4850648
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05157, Acetyl-coenzyme A synthetase, cytoplasmic
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000591 HCT 15 Homo sapiens (Human)  2
1
IC50 = 0.01 nM
   TI
   LI
   LO
   TS
2
IC50 = 1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.01 nM