Protein Information

General Information of the Protein

Protein ID	PT01443
Protein Name	Polyamine deacetylase HDAC10
Secondarily Protein Name	Histone deacetylase 10
Gene Name	HDAC10
Sequence	MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Epigenetic regulator > Eraser > Histone deacetylase > HDAC class IIb
Function	Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). Show/Hide
Uniprot ID	Primary ID: Q969S8 Secondarily ID: Q08AP4 Q6STF9 Q96P77 Q96P78 Q9H028 Q9UGX1 Q9UGX2 Show/Hide
Ensembl ID	ENSG00000100429
HGNC ID	HGNC:18128
Subcellular Location	Cytoplasm Nucleus

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000023 , BTI-Tn-5B1-4

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0444962 Compound Info	5-cyclopropyl-N-[(1S)-1-[4-(hydroxycarbamoyl)phenyl]ethyl]-2-(5-phenyl-1,3-thiazol-2-yl)-1,3-thiazole-4-carboxamide Show/Hide	C25H22N4O3S2	1
1	IC50 = 1.98 nM Bioactivity Info	TI LI LO TS
CP0003580 Compound Info	Faridak Show/Hide	C21H23N3O2	1
1	IC50 = 10.24 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0008777 Compound Info	JNJ-26481585 Show/Hide	C21H26N6O2	6
1	IC50 = 0.46 nM
2	IC50 = 0.5 nM
3	IC50 = 2.8 nM
4	IC50 = 10 nM
5	Ki = 0.05 nM
6	Ki = 4.4 nM
CP0003580 Compound Info	Faridak Show/Hide	C21H23N3O2	5
1	IC50 = 2.1 nM
2	IC50 = 2.3 nM
3	IC50 = 4 nM
4	Ki = 5.1 nM
5	Ki = 31 nM
CP0003676 Compound Info	N-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide Show/Hide	C23H24N8O4S	2
1	IC50 = 2.8 nM
2	IC50 = 3 nM
CP0004941 Compound Info	N-hydroxy-4-[[3-(pyrrolidin-1-ylmethyl)indol-1-yl]methyl]benzamide Show/Hide	C21H23N3O2	1
1	IC50 = 3.981 nM
CP0008445 Compound Info	3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide Show/Hide	C21H23N3O5	4
1	IC50 = 3.981 nM
2	IC50 = 52 nM
3	Ki = 20 nM
4	Ki = 24 nM
CP0005479 Compound Info	CHEBI:46024 Show/Hide	C17H22N2O3	15
1	IC50 = 5 nM
2	IC50 = 8 nM
3	IC50 = 11.3 nM
4	IC50 = 20 nM
5	IC50 = 20.1 nM
6	IC50 = 22.8 nM
7	IC50 = 31 nM
8	IC50 = 32 nM
9	IC50 = 34.5 nM
10	IC50 = 34.81 nM
11	IC50 = 37.9 nM
12	IC50 = 38.1 nM
13	IC50 = 61 nM
14	IC50 = 71 nM
15	Ki = 7 nM
CP0014425 Compound Info	4-[[3-[(dimethylamino)methyl]indol-1-yl]methyl]-N-hydroxybenzamide Show/Hide	C19H21N3O2	1
1	IC50 = 5.012 nM
CP0014760 Compound Info	N-hydroxy-4-[[3-(1-methylpyrrolidin-2-yl)indol-1-yl]methyl]benzamide Show/Hide	C21H23N3O2	1
1	IC50 = 5.012 nM
CP0007846 Compound Info	N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide Show/Hide	C20H21N3O2	4
1	IC50 = 12.59 nM
2	IC50 = 3710 nM
3	IC50 = 25000 nM
4	IC50 > 30000 nM
CP0007527 Compound Info	4-[[3-[(dimethylamino)methyl]indazol-1-yl]methyl]-N-hydroxybenzamide Show/Hide	C18H20N4O2	1
1	IC50 = 19.95 nM
CP0129460 Compound Info	US9249087, 19 Show/Hide	C20H23N3O2	1
1	IC50 = 19.95 nM
CP0014641 Compound Info	N-hydroxy-4-[[3-(3-methylimidazol-4-yl)indol-1-yl]methyl]benzamide Show/Hide	C20H18N4O2	1
1	IC50 = 25.12 nM
CP0003832 Compound Info	N'-hydroxy-N-phenyloctanediamide Show/Hide	C14H20N2O3	27
1	IC50 = 47.5 nM
2	IC50 = 50 nM
3	IC50 = 58 nM
4	IC50 = 64 nM
5	IC50 = 68.4 nM
6	IC50 = 70 nM
7	IC50 = 72 nM
8	IC50 = 80 nM
9	IC50 = 91.8 nM
10	IC50 = 97 nM
11	IC50 = 100 nM
12	IC50 = 150 nM
13	IC50 = 170 nM
14	IC50 = 199.53 nM
15	IC50 = 200 nM
16	IC50 = 210 nM
17	IC50 = 238.1 nM
18	IC50 = 278 nM
19	IC50 = 430 nM
20	IC50 = 432 nM
21	IC50 = 456 nM
22	IC50 = 460 nM
23	IC50 = 686 nM
24	IC50 = 982 nM
25	Ki = 40 nM
26	Ki = 50 nM
27	Ki = 60 nM
CP0119682 Compound Info	US9249087, 2 Show/Hide	C16H14N2O2	1
1	IC50 = 63.1 nM
CP0013041 Compound Info	HPOB Show/Hide	C17H18N2O4	2
1	IC50 = 79.43 nM
2	IC50 = 3000 nM
CP0562872 Compound Info	N-hydroxy-4-[[3-(2-hydroxyethyl)indol-1-yl]methyl]benzamide Show/Hide	C18H18N2O3	1
1	IC50 = 79.43 nM
CP0070180 Compound Info	tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate Show/Hide	C22H30N4O6	2
1	IC50 = 90.7 nM
2	IC50 = 316.23 nM
CP0057110 Compound Info	4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide Show/Hide	C19H23N3O3	2
1	IC50 = 100 nM
2	IC50 = 7570 nM
CP0004475 Compound Info	RICOLINOSTAT Show/Hide	C24H27N5O3	3
1	IC50 = 125.89 nM
2	IC50 = 194 nM
3	IC50 > 10000 nM
CP0064131 Compound Info	7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide Show/Hide	C24H26N4O4	1
1	IC50 = 125.89 nM
CP0244186 Compound Info	N-hydroxy-4-[[3-(2-methoxyethyl)indol-1-yl]methyl]benzamide Show/Hide	C19H20N2O3	1
1	IC50 = 125.89 nM
CP0473253 Compound Info	tert-butyl N-[[1-[[4-(hydroxycarbamoyl)phenyl]methyl]indol-3-yl]methyl]carbamate Show/Hide	C22H25N3O4	1
1	IC50 = 158.49 nM
CP0011675 Compound Info	N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-9-yl)methyl]benzamide Show/Hide	C20H21N3O2	1
1	IC50 = 199.53 nM
CP0053450 Compound Info	6-(3-adamantan-1-yl-ureido)hexanoic acid hydroxyamide Show/Hide	C17H29N3O3	1
1	IC50 = 270 nM
CP0007526 Compound Info	US9249087, 8 Show/Hide	C18H18N2O2	1
1	IC50 = 316.23 nM
CP0232823 Compound Info	4-(3,4-dihydro-1H-thiopyrano[4,3-b]indol-5-ylmethyl)-N-hydroxybenzamide Show/Hide	C19H18N2O2S	1
1	IC50 = 316.23 nM
CP0075287 Compound Info	4-[(2-acetyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]-N-hydroxybenzamide Show/Hide	C21H21N3O3	1
1	IC50 = 501.19 nM
CP0011676 Compound Info	4-(3,4-dihydro-1H-pyrano[4,3-b]indol-5-ylmethyl)-N-hydroxybenzamide Show/Hide	C19H18N2O3	1
1	IC50 = 630.96 nM
CP0348866 Compound Info	N-hydroxy-4-(1,2,3,4-tetrahydrocarbazol-9-ylmethyl)benzamide Show/Hide	C20H20N2O2	1
1	IC50 = 1000 nM
CP0013235 Compound Info	(E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide Show/Hide	C20H32Cl2N4O2	2
1	IC50 = 1584.89 nM
2	Ki = 23 nM
CP0015005 Compound Info	S-[(E)-4-[(4Z,7S,10S)-4-ethylidene-2,5,8,12-tetraoxo-7-propan-2-yl-9-oxa-16-thia-3,6,13,18-tetrazabicyclo[13.2.1]octadeca-1(17),15(18)-dien-10-yl]but-3-enyl] octanethioate Show/Hide	C29H42N4O6S2	1
1	IC50 = 1930 nM
CP0324814 Compound Info	US8748451, 5 Show/Hide	C20H16N2O2	1
1	IC50 = 1995.26 nM
CP0004988 Compound Info	pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate Show/Hide	C21H20N4O3	3
1	IC50 = 3150 nM
2	IC50 = 11100 nM
3	IC50 = 50100 nM
CP0238956 Compound Info	4-[(2-tert-butylindol-1-yl)methyl]-N-hydroxybenzamide Show/Hide	C20H22N2O2	1
1	IC50 = 5011.87 nM
CP0053451 Compound Info	6-(2-Mercapto-acetylamino)-hexanoic acid quinolin-8-ylamide Show/Hide	C17H21N3O2S	1
1	IC50 = 10650 nM
CP0014148 Compound Info	N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide Show/Hide	C17H16N2O3	3
1	IC50 = 13000 nM
2	IC50 = 39810.72 nM
3	IC50 > 20000 nM
CP0008165 Compound Info	N'-(2-aminophenyl)-N-[3-(1-phenyltriazol-4-yl)phenyl]octanediamide Show/Hide	C28H30N6O2	1
1	IC50 > 30000 nM

Clinical Information about the Protein

Target 1 ( Histone deacetylase 10 (HDAC10) )

Target Type	Patented-recorded Target
Disease	1 Target-related Disease				1
1	Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Investigative Drug(s)	1 Investigative Drug				1
1	ST-2987	Drug Info	Investigative	Solid tumour/cancer

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han