General Information of the Protein
Protein ID
PT06976
Protein Name
Potassium voltage-gated channel subfamily H member 2
Secondarily
Protein Name
Ether-a-go-go-related gene potassium channel 1
Voltage-gated potassium channel subunit Kv11.1
Gene Name
KCNH2
Secondarily
Gene Name
CERG
ERG
Sequence
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPTHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTTRESSARPGGVGSAGAPGAVVVDVDLSPAVPSRESLALDEVTAMDNHVAGLGPMEEQRALVGSSSPPAGAPEPLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGLPPPPRHASTGAMHPLRGGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPAPDCGYACQPLAVVDFIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSAELEGGFNRQRKRKLSFRRRTDRDPEQPGEVSALGPGRAGAGPSGRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLTEDGEKSSDTCNPLSGAFSGVSNIFSFWGDSRGHQYQELPRCPAPTPSLLNIPLSSPCRRPRGDVEGRLDALQRQLNRLETRLSADMATVLQLLQRQMTLIPPAYSAVTTPGPGPTSTSSLLPVSPIPTLTLDSLSQVSQFMAFEELPPGAPELPQDGPPRRLSLPGQLGALTSQPLHRHGSDPGS
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Organism
Canis lupus familiaris, Dog, Canis familiaris
Protein Classification
Ion channel
>
Voltage-gated ion channel
>
Potassium channels
>
Voltage-gated potassium channel
Function
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).
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Uniprot ID
Primary ID:
Q9TSZ3

Secondarily ID:
O02719
O18820
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0070912
 Compound Info 
3,5-dimethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,2-oxazole-4-carboxamide
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C22H30N4O2
  1
1
IC50 = 44000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT00897 Potassium voltage-gated channel subfamily H member 2 Homo sapiens, Human
 Protein Info