General Information of the Compound
Compound ID
CP0198938
Compound Name
(R)-2-(5'-methyl-2,2'-bithiophen-5-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline
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Structure
Formula
C25H26N2S2
Molecular Weight
418.631
Canonical SMILES
C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1ccc(s1)-c1ccc(C)s1
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InChI
InChI=1S/C25H26N2S2/c1-17-4-3-14-27(17)15-13-19-6-8-21-20(16-19)7-9-22(26-21)23-11-12-25(29-23)24-10-5-18(2)28-24/h5-12,16-17H,3-4,13-15H2,1-2H3/t17-/m1/s1
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InChIKey
NCDVDCYFZPSORZ-QGZVFWFLSA-N
Physicochemical Property
logP
7.02702
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
16.13
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11697412
SID: 16801921
ChEMBL ID
CHEMBL1085124
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2000 nM