General Information of the Compound
Compound ID
CP0179956
Compound Name
N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
    Show/Hide
Synonyms
Flecaine
(+-)-Flecainide
(-)-Flecainide
54143-55-4
Almarytm (TN)
Apocard (TN)
Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-
C17H20F6N2O3
CCRIS 313
CHEBI:75984
CHEMBL652
DJBNUMBKLMJRSA-UHFFFAOYSA-N
DSSTox_CID_3054
DSSTox_GSID_23054
DSSTox_RID_76854
Ecrinal (TN)
Flecaine
Flecainida
Flecainida [INN-Spanish]
Flecainide
Flecainide (INN)
Flecainide [INN:BAN]
Flecainidum
Flecainidum [INN-Latin]
Ic Flecainide
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
N-(piperidin-2-ylmethyl)-2,5-bis[(2,2,2-trifluoroethyl)oxy]benzamide
NCGC00015443-06
Tambocor
Tambocor (TN)
flecainide
    Show/Hide
Structure
Formula
C17H20F6N2O3
Molecular Weight
414.346
Canonical SMILES
FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1
    Show/Hide
InChI
InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)
    Show/Hide
InChIKey
DJBNUMBKLMJRSA-UHFFFAOYSA-N
CAS
54143-55-4
99495-87-1
Physicochemical Property
logP
3.4407
Rotatable Bonds
7
Heavy Atom Count
28
Polar Areas
59.59
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 3356
SID: 14879920
ChEMBL ID
CHEMBL652
DrugBank ID
DB01195
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3890.45 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3890.45 nM
Clinical Information about the Compound
Drug 1 ( Flecainide )
Drug Name Flecainide
Company 3M pharmaceuticals
Indication
Tachyarrhythmias
Approved
Paroxysmal atrial fibrillation
Phase 1
Atrial fibrillation
Investigative