General Information of the Compound
Compound ID
CP0048166
Compound Name
2-[[5-cyano-4-[2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]sulfanyl]-N-methylacetamide
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Structure
Formula
C22H24Cl2N6O2S
Molecular Weight
507.447
Canonical SMILES
CCN(CC)CCOc1cc(c(Cl)cc1Cl)-c1nc(SCC(=O)NC)nc2[nH]cc(C#N)c12
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InChI
InChI=1S/C22H24Cl2N6O2S/c1-4-30(5-2)6-7-32-17-8-14(15(23)9-16(17)24)20-19-13(10-25)11-27-21(19)29-22(28-20)33-12-18(31)26-3/h8-9,11H,4-7,12H2,1-3H3,(H,26,31)(H,27,28,29)
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InChIKey
ABQRRZZEGCBSBT-UHFFFAOYSA-N
Physicochemical Property
logP
4.36208
Rotatable Bonds
10
Heavy Atom Count
33
Polar Areas
106.93
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24875846
SID: 50131265
ChEMBL ID
CHEMBL2158563
Table of Molecular Bioactivities Related to the Compound
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000218 BT-474 Homo sapiens (Human)  1
1
GI50 = 78 nM
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