General Information of the Compound
Compound ID
CP0337894
Compound Name
(1R)-2-[4-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]-1-(6-methoxy-1,5-naphthyridin-4-yl)ethanol
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Structure
Formula
C24H29N5O4
Molecular Weight
451.527
Canonical SMILES
COc1ccc2nccc([C@@H](O)CN3CCC(CC3)NCc3cc4OCCOc4cn3)c2n1
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InChI
InChI=1S/C24H29N5O4/c1-31-23-3-2-19-24(28-23)18(4-7-25-19)20(30)15-29-8-5-16(6-9-29)26-13-17-12-21-22(14-27-17)33-11-10-32-21/h2-4,7,12,14,16,20,26,30H,5-6,8-11,13,15H2,1H3/t20-/m0/s1
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InChIKey
PITSXODQFZPJCK-FQEVSTJZSA-N
Physicochemical Property
logP
2.0922
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
101.86
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10297708
SID: 15304404
ChEMBL ID
CHEMBL1927161
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 4000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 25100 nM