General Information of the Compound
Compound ID
CP0126643
Compound Name
(R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(4-(piperidin-1-yl)phenyl)quinoline
    Show/Hide
Structure
Formula
C27H33N3
Molecular Weight
399.582
Canonical SMILES
C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1ccc(cc1)N1CCCCC1
    Show/Hide
InChI
InChI=1S/C27H33N3/c1-21-6-5-18-29(21)19-15-22-7-13-27-24(20-22)10-14-26(28-27)23-8-11-25(12-9-23)30-16-3-2-4-17-30/h7-14,20-21H,2-6,15-19H2,1H3/t21-/m1/s1
    Show/Hide
InChIKey
ZKIWXUBGHCOMER-OAQYLSRUSA-N
Physicochemical Property
logP
5.9189
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
19.37
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 11524148
SID: 16626132
ChEMBL ID
CHEMBL1085336
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 690 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2800 nM