General Information of the Compound
Compound ID
CP0371098
Compound Name
3-(1-Methyl-piperidin-3-yl)-2-phenyl-1H-indole
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Synonyms
3-(1-Methyl-piperidin-3-yl)-2-phenyl-1H-indole
3-(1-methylpiperidin-3-yl)-2-phenyl-1H-indole
BDBM50099264
CHEMBL43819
SCHEMBL8525408
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Structure
Formula
C20H22N2
Molecular Weight
290.41
Canonical SMILES
CN1CCCC(C1)c1c([nH]c2ccccc12)-c1ccccc1
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InChI
InChI=1S/C20H22N2/c1-22-13-7-10-16(14-22)19-17-11-5-6-12-18(17)21-20(19)15-8-3-2-4-9-15/h2-6,8-9,11-12,16,21H,7,10,13-14H2,1H3
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InChIKey
JRFXDRYERZNJFJ-UHFFFAOYSA-N
Physicochemical Property
logP
4.6441
Rotatable Bonds
2
Heavy Atom Count
22
Polar Areas
19.03
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9838960
SID: 14800066
ChEMBL ID
CHEMBL43819
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00825, 5-hydroxytryptamine receptor 2A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4.7 nM
   TI
   LI
   LO
   TS
Protein ID: PT00939, 5-hydroxytryptamine receptor 2C
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 150 nM
   TI
   LI
   LO
   TS
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 28 nM
   TI
   LI
   LO
   TS
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 9600 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 9599.99 nM
Clinical Information about the Compound
Drug 1 ( 3-(1-Methyl-piperidin-3-yl)-2-phenyl-1H-indole )
Drug Name 3-(1-Methyl-piperidin-3-yl)-2-phenyl-1H-indole
Target(s)
Voltage-gated potassium channel Kv11.1 (KCNH2)
Inhibitor