General Information of the Compound
Compound ID
CP0238238
Compound Name
(R)-4-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-2-(pyridin-3-yl)thiazole
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Structure
Formula
C25H26N4S
Molecular Weight
414.578
Canonical SMILES
C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1sc(nc1C)-c1cccnc1
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InChI
InChI=1S/C25H26N4S/c1-17-5-4-13-29(17)14-11-19-7-9-22-20(15-19)8-10-23(28-22)24-18(2)27-25(30-24)21-6-3-12-26-16-21/h3,6-10,12,15-17H,4-5,11,13-14H2,1-2H3/t17-/m1/s1
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InChIKey
SQRYZHXHZZAKRK-QGZVFWFLSA-N
Physicochemical Property
logP
5.75552
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
41.91
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11633028
SID: 16736198
ChEMBL ID
CHEMBL1082606
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00897, Potassium voltage-gated channel subfamily H member 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6000 nM