Protein Information

General Information of the Protein

Protein ID	PT01169
Protein Name	D(1B) dopamine receptor
Secondarily Protein Name	D(5) dopamine receptor D1beta dopamine receptor Dopamine D5 receptor
Gene Name	DRD5
Secondarily Gene Name	DRD1B DRD1L2
Sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Dopamine receptor
Function	Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Show/Hide
Uniprot ID	Primary ID: P21918 Secondarily ID: B2R9S3 Q8NEQ8 Show/Hide
Ensembl ID	ENSG00000169676
HGNC ID	HGNC:3026
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0059819 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-ol Show/Hide	C18H21NO	1
1	Ki = 1.5 nM Bioactivity Info	TI LI LO TS
CP0089986 Compound Info	STEPHOLIDINE Show/Hide	C19H21NO4	1
1	Ki = 4.4 nM Bioactivity Info	TI LI LO TS
CP0430707 Compound Info	5,8,13,13a-Tetrahydro-6H-isoquino[3,2-a]isoquinolin-3-ol Show/Hide	C17H17NO	1
1	Ki = 41.1 nM Bioactivity Info	TI LI LO TS
CP0040242 Compound Info	16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene Show/Hide	C19H23NO	1
1	Ki = 54 nM Bioactivity Info	TI LI LO TS
CP0375584 Compound Info	3-Methoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline Show/Hide	C18H19NO	1
1	Ki = 185 nM Bioactivity Info	TI LI LO TS
CP0375581 Compound Info	10-Methoxy-6-methyl-5,6,7,8,13,14-hexahydrodibenzo[c,g]azecine Show/Hide	C19H23NO	1
1	Ki = 1508 nM Bioactivity Info	TI LI LO TS
CP0375575 Compound Info	6-Methyl-5,6,7,8,9,14-hexahydrodibenzo[c,f]azecin-11-ol Show/Hide	C18H21NO	1
1	Ki = 1810 nM Bioactivity Info	TI LI LO TS
CP0287080 Compound Info	3-methoxy-5,8,9,13b-tetrahydro-6H-isoquino-[1,2-a]isoquinoline Show/Hide	C18H19NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0375574 Compound Info	6-Methoxy-2-methyl-1-(2-methylbenzyl)-1,2,3,4-tetrahydroisoquinoline Show/Hide	C19H23NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0375582 Compound Info	2-Methyl-1-(2-methylbenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol Show/Hide	C18H21NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0375583 Compound Info	6-Methyl-5,6,7,8,13,14-hexahydrodibenzo[c,g]azecin-10-ol Show/Hide	C18H21NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0375585 Compound Info	3-Methoxy-6,7,9,13b-tetrahydro-5H-isoindolo[1,2-a][2]benzazepine Show/Hide	C18H19NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0428950 Compound Info	11-Methoxy-6-methyl-5,6,7,8,9,14-hexahydrodibenzo[c,f]azecine Show/Hide	C19H23NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0430705 Compound Info	6,8,9,13b-tetrahydro-5H-isoquinolino[1,2-a]isoquinolin-3-ol Show/Hide	C17H17NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0470276 Compound Info	3-(2-Ethyl-4-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline Show/Hide	C19H23NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0376284 Compound Info	(2S)-4-[(3,4-dimethylphenyl)methyl]-2-(phenylsulfanylmethyl)morpholine Show/Hide	C20H25NOS	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0401192 Compound Info	(2S)-2-[(6-chloropyridin-2-yl)oxymethyl]-4-[(6-fluoro-1H-indol-3-yl)methyl]morpholine Show/Hide	C19H19ClFN3O2	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0452595 Compound Info	(2S)-4-[(4-chlorophenyl)methyl]-2-(phenylsulfanylmethyl)morpholine Show/Hide	C18H20ClNOS	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000029 , GH4C1

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000041 , LTK-

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0165743 Compound Info	4-Chloro-3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H20ClNO	1
1	Ki = 0.057 nM
CP0338716 Compound Info	1-Chloro-2-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H20ClNO	1
1	Ki = 0.98 nM
CP0059819 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-ol Show/Hide	C18H21NO	1
1	Ki = 1.5 nM
CP0099064 Compound Info	3,11-Dihydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H21NO2	1
1	Ki = 1.68 nM
CP0046343 Compound Info	(6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahydro-6H-7-aza-benzo[6,7]cyclohepta[1,2-a]naphthalen-12-ol Show/Hide	C19H20ClNO	1
1	Ki = 2 nM
CP0059813 Compound Info	3-Chloro-2-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H20ClNO	1
1	Ki = 4.9 nM
CP0082972 Compound Info	11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{15,20}]henicosa-1(14),3(8),4,6,15,17,19-heptaene Show/Hide	C20H22N2	2
1	Ki = 7.5 nM
2	Ki < 10 nM
CP0175178 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene Show/Hide	C18H21N	1
1	Ki = 11.2 nM
CP0186639 Compound Info	3,11-Dimethoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C20H25NO2	1
1	Ki = 12.6 nM
CP0074631 Compound Info	6-methyl-4,5,6,7,8,13-hexahydrothieno[2,3-f][3]benzazecine Show/Hide	C16H19NS	1
1	Ki = 15 nM
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	3
1	Ki = 38 nM
2	Ki = 58 nM
3	Ki = 260 nM
CP0155138 Compound Info	2-Hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H21NO	1
1	Ki = 42.3 nM
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	1
1	Ki = 100 nM
CP0162167 Compound Info	2-Amino-3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H22N2O	1
1	Ki = 226.5 nM
CP0078330 Compound Info	7-[4-[4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one Show/Hide	C24H29Cl2N3O2	1
1	Ki = 615 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	2
1	Ki = 780 nM
2	Ki = 1000 nM
CP0042927 Compound Info	7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one Show/Hide	C23H27Cl2N3O2	2
1	Ki = 1051 nM
2	Ki > 1000 nM
CP0424210 Compound Info	2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide Show/Hide	C21H25N3O3S	1
1	Ki = 1629 nM

Clinical Information about the Protein

Target 1 ( Dopamine D5 receptor (D5R) )

Target Type	Successful Target
Disease	2 Target-related Diseases				2
1	Allergy [ICD-11: 4A80-4A85]
2	Schizophrenia [ICD-11: 6A20]
Approved Drug(s)	1 Approved Drug				1
1	Phenyltoloxamine	Drug Info	Approved	Allergy
Discontinued Drug(s)	2 Discontinued Drugs				2
1	GMC-283	Drug Info	Terminated	Schizophrenia
2	ZD-3638	Drug Info	Terminated	Schizophrenia
Preclinical Drug(s)	1 Preclinical Drug				1
1	LE-300	Drug Info	Preclinical	Schizophrenia

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han