Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
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 PubChem ID
CID: 135398737
SID: 14826474
Canonical SMILES
CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
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Compound Formula C18H19ClN4
Compound Structure
Protein Name
 Protein Info 
D(3) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P35462
Gene Name
DRD3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  6
1
Ki = 88 nM
   TI
   LI
   LO
   TS
2
Ki = 100 nM
   TI
   LI
   LO
   TS
3
Ki = 200 nM
   TI
   LI
   LO
   TS
4
Ki = 295 nM
   TI
   LI
   LO
   TS
5
Ki = 454 nM
   TI
   LI
   LO
   TS
6
Ki = 960 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 222 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 200 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 319 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 450 nM
2 Ki = 239.88 nM
3 Ki = 240 nM
4 Ki = 242 nM
5 Ki = 280 nM
6 Ki = 319 nM
7 Ki = 360 nM
8 Ki = 372.3 nM
9 Ki = 912.01 nM
10 Ki = 960 nM
11 Ki = 1000 nM