Protein Information

General Information of the Protein

Protein ID	PT00943
Protein Name	D(3) dopamine receptor
Secondarily Protein Name	Dopamine D3 receptor
Gene Name	DRD3
Sequence	MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Dopamine receptor
Function	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Show/Hide
Uniprot ID	Primary ID: P35462 Secondarily ID: A1A4V5 Q4VBM8 Show/Hide
HGNC ID	HGNC:3024
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000367 , AtT-20

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0428158 Compound Info	(+)-N6-(2-(4-(2,3-Dichlorophenyl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Show/Hide	C22H31Cl2N5S	1
1	EC50 = 0.06 nM Bioactivity Info	TI LI LO TS
CP0417213 Compound Info	6-[(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C26H37N3O2	1
1	EC50 = 0.08 nM Bioactivity Info	TI LI LO TS
CP0422698 Compound Info	(-)-N6-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Show/Hide	C28H37N5S	1
1	EC50 = 0.085 nM Bioactivity Info	TI LI LO TS
CP0402710 Compound Info	(S)-N6-[2-(4-Biphenyl-4-yl-piperazin-1-yl)-ethyl]-N6-propyl-4,5,6,7-tetrahydro-benzothiazole-2,6-diamine Show/Hide	C28H37N5S	1
1	EC50 = 0.085 nM Bioactivity Info	TI LI LO TS
CP0378421 Compound Info	(+)-6-[(2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C25H35N3O	1
1	EC50 = 0.12 nM Bioactivity Info	TI LI LO TS
CP0402681 Compound Info	(-)-(S)-N6-Propyl-N6-(2-(4-(quinolin-4-yl)piperazin-1-yl)ethyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Show/Hide	C25H34N6S	1
1	EC50 = 0.493 nM Bioactivity Info	TI LI LO TS
CP0411950 Compound Info	(-)-(S)-N6-(2-(4-(Isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine Show/Hide	C25H34N6S	1
1	EC50 = 0.52 nM Bioactivity Info	TI LI LO TS
CP0402682 Compound Info	(-)-(S)-N6-Propyl-N6-(2-(4-(quinolin-5-yl)piperazin-1-yl)ethyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Show/Hide	C25H34N6S	1
1	EC50 = 0.528 nM Bioactivity Info	TI LI LO TS
CP0162854 Compound Info	(+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol Show/Hide	C16H25NO	1
1	EC50 = 0.531 nM Bioactivity Info	TI LI LO TS
CP0378423 Compound Info	7-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-2-ol Show/Hide	C25H35N3O	1
1	EC50 = 0.69 nM Bioactivity Info	TI LI LO TS
CP0103545 Compound Info	(-)-5-hydroxy-2-(dipropylamino)tetralin Show/Hide	C16H25NO	1
1	EC50 = 1.23 nM Bioactivity Info	TI LI LO TS
CP0036921 Compound Info	3-HYDROXYTYRAMINE HYDROCHLORIDE Show/Hide	C8H11NO2	1
1	EC50 = 8.53 nM Bioactivity Info	TI LI LO TS
CP0078778 Compound Info	4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one Show/Hide	C16H24N2O	1
1	EC50 = 19.2 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL001028 , CHO Pro-5

Cell Line Info

Cell Line ID: CL000389 , CHO-DXB11

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000153 , CHOP

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000883 , HTLA

Cell Line Info

Cell Line ID: CL001064 , PathHunter U2OS DRD3 beta-arrestin

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000043 , U2OS

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0290176 Compound Info	(S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-3-carbaldehyde Show/Hide	C15H24N2O	1
1	EC50 = 1.1 nM
CP0127400 Compound Info	(-)-Pramipexole Show/Hide	C10H17N3S	4
1	EC50 = 1.5 nM
2	Ki = 0.87 nM
3	Ki = 0.9 nM
4	Ki = 8.5 nM
CP0006107 Compound Info	CAS_85760-74-3 Show/Hide	C13H21N3	2
1	EC50 = 2.6 nM
2	Ki = 12.5 nM
CP0051912 Compound Info	(5S)-N,N-dipropyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-5-amine Show/Hide	C13H23N3	2
1	EC50 = 3.4 nM
2	Ki = 8.4 nM
CP0051933 Compound Info	(3-Chloro-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridin-5-yl)-dipropyl-amine Show/Hide	C13H22ClN3	1
1	EC50 = 4.5 nM
CP0049047 Compound Info	(+)butaclamol Show/Hide	C25H31NO	6
1	IC50 = 1.2 nM
2	IC50 = 1.9 nM
3	IC50 = 6.6 nM
4	IC50 = 10 nM
5	Ki = 0.43 nM
6	Ki = 1.4 nM
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	15
1	IC50 = 10 nM
2	Ki = 0.69 nM
3	Ki = 2.5 nM
4	Ki = 2.74 nM
5	Ki = 4.4 nM
6	Ki = 4.571 nM
7	Ki = 4.6 nM
8	Ki = 5.5 nM
9	Ki = 7.8 nM
10	Ki = 10 nM
11	Ki = 10.4 nM
12	Ki = 11.48 nM
13	Ki = 13.5 nM
14	Ki = 16 nM
15	Ki = 21 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	11
1	IC50 = 450 nM
2	Ki = 239.88 nM
3	Ki = 240 nM
4	Ki = 242 nM
5	Ki = 280 nM
6	Ki = 319 nM
7	Ki = 360 nM
8	Ki = 372.3 nM
9	Ki = 912.01 nM
10	Ki = 960 nM
11	Ki = 1000 nM
CP0118796 Compound Info	Cariprazine Show/Hide	C21H32Cl2N4O	1
1	Ki = 0.085 nM
CP0037498 Compound Info	4-Cyano-1-methoxy-naphthalene-2-carboxylic acid (1-butyl-pyrrolidin-2-ylmethyl)-amide Show/Hide	C22H27N3O2	1
1	Ki = 0.11 nM
CP0044513 Compound Info	7-Methoxy-benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C24H27Cl2N3O3	1
1	Ki = 0.13 nM
CP0266686 Compound Info	N-[4-[(4-ethynylcyclohex-3-en-1-yl)-propylamino]butyl]-4-phenylbenzamide Show/Hide	C28H34N2O	1
1	Ki = 0.2 nM
CP0104676 Compound Info	Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C24H29N3O2S	1
1	Ki = 0.23 nM
CP0040671 Compound Info	8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C23H26FN3O2	2
1	Ki = 0.25 nM
2	Ki = 0.32 nM
CP0099825 Compound Info	4'-Acetyl-biphenyl-4-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C30H35N3O3	1
1	Ki = 0.32 nM
CP0314424 Compound Info	1H-Indole-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C24H30N4O2	1
1	Ki = 0.32 nM
CP0051858 Compound Info	N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-hydroxybenzamide Show/Hide	C21H23Cl2N3O2	1
1	Ki = 0.4 nM
CP0043442 Compound Info	Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C23H25Cl2N3OS	2
1	Ki = 0.5 nM
2	Ki = 0.8 nM
CP0049308 Compound Info	N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-4-pyridin-2-ylbenzamide Show/Hide	C26H28Cl2N4O	1
1	Ki = 0.5 nM
CP0080177 Compound Info	4-bromo-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide Show/Hide	C22H28BrN3O2	1
1	Ki = 0.5012 nM
CP0122857 Compound Info	(R)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-hydroxybutyl)-1H-indole-2-carboxamide Show/Hide	C23H26Cl2N4O2	2
1	Ki = 0.53 nM
2	Ki = 2.9 nM
CP0137444 Compound Info	3-(2-Methoxy-phenyl)-N-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-acrylamide Show/Hide	C25H33N3O3	1
1	Ki = 0.56 nM
CP0105569 Compound Info	N-[4-(4-phenylpiperazin-1-yl)butyl]quinoline-6-carboxamide Show/Hide	C24H28N4O	1
1	Ki = 0.6 nM
CP0036302 Compound Info	N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]quinolin-2-amine Show/Hide	C23H26Cl2N4	1
1	Ki = 0.6 nM
CP0226491 Compound Info	1-(3-chlorophenyl)-3-[2-(4,6,7,8-tetrahydrothieno[3,2-c]azepin-5-yl)ethyl]imidazolidin-2-one Show/Hide	C19H22ClN3OS	1
1	Ki = 0.631 nM
CP0061556 Compound Info	N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-pyridin-2-ylbenzamide Show/Hide	C26H26Cl2N4O	1
1	Ki = 0.7 nM
CP0159533 Compound Info	N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-nitrobenzamide Show/Hide	C21H22Cl2N4O3	1
1	Ki = 0.7 nM
CP0097606 Compound Info	3-[2-oxo-3-[2-[4-(trifluoromethyl)piperidin-1-yl]ethyl]imidazolidin-1-yl]benzonitrile Show/Hide	C18H21F3N4O	1
1	Ki = 0.7943 nM
CP0041389 Compound Info	Benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C23H25Cl2N3O2	2
1	Ki = 0.8 nM
2	Ki = 1.5 nM
CP0348511 Compound Info	N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]benzamide Show/Hide	C21H23Cl2N3O	1
1	Ki = 0.8 nM
CP0184444 Compound Info	Biphenylene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C27H27Cl2N3O	1
1	Ki = 0.9 nM
CP0280047 Compound Info	S33084 Show/Hide	C29H29N3O2	1
1	Ki = 0.934498 nM
CP0228156 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoquinolin-1-amine Show/Hide	C24H30N4O	1
1	Ki = 1 nM
CP0332248 Compound Info	N-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]butyl]isoquinolin-1-amine Show/Hide	C24H27F3N4	1
1	Ki = 1 nM
CP0045037 Compound Info	Benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C24H29N3O3	1
1	Ki = 1.1 nM
CP0047599 Compound Info	Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-amide Show/Hide	C23H23Cl2N3OS	1
1	Ki = 1.1 nM
CP0255045 Compound Info	N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-methoxybenzamide Show/Hide	C22H25Cl2N3O2	1
1	Ki = 1.2 nM
CP0302329 Compound Info	1-[2-[(1R,5S)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-3-(3-chlorophenyl)imidazolidin-2-one Show/Hide	C18H24ClN3O	1
1	Ki = 1.259 nM
CP0044515 Compound Info	6-((4-methoxyphenylsulfonyl)methyl)-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine Show/Hide	C24H33NO3S	1
1	Ki = 1.3 nM
CP0153901 Compound Info	2-(4-{3-[4-(2-Propylsulfanyl-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-1H-benzoimidazole Show/Hide	C29H34N4OS	1
1	Ki = 1.3 nM
CP0183672 Compound Info	9-Oxo-9H-fluorene-4-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C28H27Cl2N3O2	1
1	Ki = 1.4 nM
CP0071762 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide Show/Hide	C26H31N3O2	1
1	Ki = 1.4 nM
CP0276368 Compound Info	N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]quinoxaline-2-carboxamide Show/Hide	C23H25Cl2N5O	1
1	Ki = 1.4 nM
CP0042204 Compound Info	1H-Indole-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C23H26Cl2N4O	1
1	Ki = 1.4 nM
CP0065124 Compound Info	9H-Fluorene-2-carboxylic acid {(E)-4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-amide Show/Hide	C28H27Cl2N3O	1
1	Ki = 1.5 nM
CP0248661 Compound Info	2-{4-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-phenyl}-1H-benzoimidazole Show/Hide	C26H28N4O	1
1	Ki = 1.5 nM
CP0348222 Compound Info	N-[4-[[(1R,2R)-2-(2,3-dichlorophenyl)cyclopropyl]methyl-propylamino]butyl]-4-pyridin-2-ylbenzamide;hydrochloride Show/Hide	C29H34Cl3N3O	1
1	Ki = 1.5 nM
CP0048038 Compound Info	2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one Show/Hide	C25H33N3O2	1
1	Ki = 1.585 nM
CP0043968 Compound Info	7-(2,5-dimethylpyrazol-3-yl)-3-[3-[[4-methyl-5-(2-methylquinolin-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1,2,4,5-tetrahydro-3-benzazepine Show/Hide	C31H35N7S	1
1	Ki = 1.585 nM
CP0089667 Compound Info	CHEMBL558058 Show/Hide	C23H32F3N3O	1
1	Ki = 1.585 nM
CP0302789 Compound Info	N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-4-iodobenzamide Show/Hide	C21H24Cl2IN3O	1
1	Ki = 1.6 nM
CP0218398 Compound Info	6-[5-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]pentanoyl]-1-azatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-11-one Show/Hide	C28H30FN3O3	1
1	Ki = 1.66 nM
CP0041783 Compound Info	1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea Show/Hide	C20H26N4O	1
1	Ki = 1.7 nM
CP0057510 Compound Info	2-(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-1H-benzoimidazole Show/Hide	C27H30N4O2	1
1	Ki = 1.7 nM
CP0079495 Compound Info	9H-Fluorene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C28H29Cl2N3O	1
1	Ki = 2 nM
CP0142597 Compound Info	N-[4-[2-[(3aR,9bS)-8-cyano-3,3a,4,9b-tetrahydro-1H-chromeno[3,4-c]pyrrol-2-yl]ethyl]phenyl]acetamide Show/Hide	C22H23N3O2	1
1	Ki = 2 nM
CP0044765 Compound Info	Benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-amide Show/Hide	C23H23Cl2N3O2	1
1	Ki = 2.1 nM
CP0116811 Compound Info	5-Bromo-N-{4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-2,3-dimethoxy-benzamide Show/Hide	C23H28BrCl2N3O3	1
1	Ki = 2.1 nM
CP0382966 Compound Info	N-[4-[[(1R,2R)-2-(2,3-dichlorophenyl)cyclopropyl]methyl-propylamino]butyl]-1H-indole-2-carboxamide;hydrochloride Show/Hide	C26H32Cl3N3O	1
1	Ki = 2.2 nM
CP0681805 Compound Info	(R)-2-[(Benzylamino)methyl]chroman-7-ol oxalate Show/Hide	C19H21NO6	1
1	Ki = 2.4 nM
CP0049020 Compound Info	1-(3-chlorophenyl)-3-[2-(1,3-dihydroisoindol-2-yl)ethyl]imidazolidin-2-one Show/Hide	C19H20ClN3O	1
1	Ki = 2.512 nM
CP0057009 Compound Info	1-[2-[(1R,10S)-11-azatricyclo[8.2.2.03,8]tetradeca-3,5,7-trien-11-yl]ethyl]-3-(3-chlorophenyl)imidazolidin-2-one Show/Hide	C24H28ClN3O	1
1	Ki = 2.512 nM
CP0086649 Compound Info	1-(3-chlorophenyl)-3-[2-(diethylamino)ethyl]imidazolidin-2-one Show/Hide	C15H22ClN3O	1
1	Ki = 2.512 nM
CP0280650 Compound Info	1-[2-[(1R,4S)-2-azabicyclo[2.2.1]heptan-2-yl]ethyl]-3-(3-chlorophenyl)imidazolidin-2-one Show/Hide	C17H22ClN3O	1
1	Ki = 2.512 nM
CP0142590 Compound Info	2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-3,4-dihydroisoquinolin-1(2H)-one Show/Hide	C24H31N3O2	1
1	Ki = 2.63 nM
CP0097278 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-5-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 2.8 nM
CP0078778 Compound Info	4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one Show/Hide	C16H24N2O	3
1	Ki = 2.9 nM
2	Ki = 19 nM
3	Ki = 61 nM
CP0036303 Compound Info	N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]isoquinolin-1-amine Show/Hide	C23H26Cl2N4	1
1	Ki = 3.1 nM
CP0772206 Compound Info	SID56463240 Show/Hide	C26H32ClN3O2	1
1	Ki = 3.1 nM
CP0092522 Compound Info	CHEMBL565075 Show/Hide	C19H26ClN3O	1
1	Ki = 3.162 nM
CP0042927 Compound Info	7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one Show/Hide	C23H27Cl2N3O2	5
1	Ki = 3.3 nM
2	Ki = 9.7 nM
3	Ki = 10 nM
4	Ki = 10.8 nM
5	Ki = 19 nM
CP0348507 Compound Info	N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-iodobenzamide Show/Hide	C21H22Cl2IN3O	1
1	Ki = 3.4 nM
CP0427995 Compound Info	Amisulpride Show/Hide	C17H27N3O4S	1
1	Ki = 3.5 nM
CP0348221 Compound Info	N-[4-[[(1S,2S)-2-(5-fluoro-2-methoxyphenyl)cyclopropyl]methyl-propylamino]butyl]-4-pyridin-2-ylbenzamide;hydrochloride Show/Hide	C30H37ClFN3O2	1
1	Ki = 3.8 nM
CP0077362 Compound Info	N-[2-(3-chloro-4-methylphenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C18H22ClNO2	1
1	Ki = 3.89 nM
CP0200768 Compound Info	CHEMBL85606 Show/Hide	C28H30N4O	1
1	Ki = 3.981 nM
CP0076352 Compound Info	9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline; compound with methanesulfonic acid Show/Hide	C19H26N2S	1
1	Ki = 4 nM
CP0533678 Compound Info	N-[4-[[(1R,2R)-2-(5-fluoro-2-methoxyphenyl)cyclopropyl]methyl-propylamino]butyl]-4-pyridin-2-ylbenzamide;hydrochloride Show/Hide	C30H37ClFN3O2	1
1	Ki = 4.1 nM
CP0194254 Compound Info	4-(1H-imidazol-1-yl)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)benzamide Show/Hide	C25H31N5O2	1
1	Ki = 4.23 nM
CP0045034 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 4.3 nM
CP0224658 Compound Info	8-chloro-7-[4-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]butoxy]-4-methylchromen-2-one Show/Hide	C26H26ClFN2O4	1
1	Ki = 4.3 nM
CP0267566 Compound Info	N-[4-[[(1R,2R)-2-(2,3-dichlorophenyl)cyclopropyl]methyl-propylamino]butyl]naphthalene-2-carboxamide;hydrochloride Show/Hide	C28H33Cl3N2O	1
1	Ki = 4.4 nM
CP0089932 Compound Info	N-[4-[4-(3-methylphenyl)piperazin-1-yl]butyl]-1-benzofuran-2-carboxamide Show/Hide	C24H29N3O2	1
1	Ki = 4.5 nM
CP0247588 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-2,1,3-benzoxadiazole-5-carboxamide Show/Hide	C22H27N5O3	1
1	Ki = 4.7 nM
CP0104098 Compound Info	CHEMBL563435 Show/Hide	C23H35N3O2	1
1	Ki = 5.012 nM
CP0129799 Compound Info	(4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine Show/Hide	C14H23N	5
1	Ki = 5.2 nM
2	Ki = 23 nM
3	Ki = 350 nM
4	Ki = 590 nM
5	Ki = 720 nM
CP0384469 Compound Info	N-[4-[[(1S,2S)-2-(2,3-dichlorophenyl)cyclopropyl]methyl-propylamino]butyl]-4-pyridin-2-ylbenzamide;hydrochloride Show/Hide	C29H34Cl3N3O	1
1	Ki = 5.3 nM
CP0156986 Compound Info	4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-indol-2-one Show/Hide	C19H21N3O	1
1	Ki = 5.4 nM
CP0001212 Compound Info	1-(2-methoxyphenyl)-4-[3-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]propyl]piperazine Show/Hide	C23H29N5OS	1
1	Ki = 6 nM
CP0043471 Compound Info	CHEMBL563274 Show/Hide	C22H32ClN3O	1
1	Ki = 6.31 nM
CP0039958 Compound Info	(risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H27FN4O2	8
1	Ki = 6.7 nM
2	Ki = 9.6 nM
3	Ki = 13 nM
4	Ki = 14 nM
5	Ki = 14.3 nM
6	Ki = 16 nM
7	Ki = 16.22 nM
8	Ki = 100 nM
CP0056386 Compound Info	5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one Show/Hide	C21H21ClN4OS	3
1	Ki = 7.2 nM
2	Ki = 7.5 nM
3	Ki = 10 nM
CP0042751 Compound Info	(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrate;hydrochloride Show/Hide	C17H17NO2	1
1	Ki = 7.8 nM
CP0060239 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide Show/Hide	C22H29N3O2	1
1	Ki = 7.8 nM
CP0067392 Compound Info	2-{4-[3-(4-Pyridin-2-yl-piperazin-1-yl)-propoxy]-phenyl}-1H-benzoimidazole Show/Hide	C25H27N5O	1
1	Ki = 8 nM
CP0046703 Compound Info	1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one Show/Hide	C24H26ClFN4O	1
1	Ki = 8.2 nM
CP0043472 Compound Info	CHEMBL562948 Show/Hide	C22H33N3O	1
1	Ki = 10 nM
CP0033479 Compound Info	(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Show/Hide	C17H19ClN2S	1
1	Ki = 11 nM
CP0092517 Compound Info	1-(3-chlorophenyl)-3-[2-[(1S,5R)-1,3,3-trimethyl-6-azabicyclo[3.2.1]octan-6-yl]ethyl]imidazolidin-2-one Show/Hide	C21H30ClN3O	1
1	Ki = 12.59 nM
CP0426727 Compound Info	N-[4-[[(1S,2S)-2-(2,3-dichlorophenyl)cyclopropyl]methyl-propylamino]butyl]-1H-indole-2-carboxamide;hydrochloride Show/Hide	C26H32Cl3N3O	1
1	Ki = 12.8 nM
CP0036921 Compound Info	3-HYDROXYTYRAMINE HYDROCHLORIDE Show/Hide	C8H11NO2	5
1	Ki = 13.2 nM
2	Ki = 50 nM
3	Ki = 52 nM
4	Ki = 290 nM
5	Ki = 1600 nM
CP0036333 Compound Info	(S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxy-benzamide Show/Hide	C15H20Cl2N2O3	1
1	Ki = 13.4 nM
CP0254479 Compound Info	2-{4-[3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propoxy]-phenyl}-1H-benzoimidazole Show/Hide	C24H26N6O	1
1	Ki = 15 nM
CP0092523 Compound Info	1-(3-chlorophenyl)-3-[2-[(1S,5R)-1,8,8-trimethyl-3-azabicyclo[3.2.1]octan-3-yl]ethyl]imidazolidin-2-one Show/Hide	C21H30ClN3O	1
1	Ki = 15.85 nM
CP0078330 Compound Info	7-[4-[4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one Show/Hide	C24H29Cl2N3O2	1
1	Ki = 16 nM
CP0083959 Compound Info	4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,2,3,6-tetrahydro-pyridine Show/Hide	C24H27N	1
1	Ki = 16.6 nM
CP0050117 Compound Info	N-[2-(2-chlorophenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C17H20ClNO2	1
1	Ki = 16.98 nM
CP0319242 Compound Info	2-(4-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-1H-benzoimidazole Show/Hide	C26H27ClN4O	1
1	Ki = 18 nM
CP0084969 Compound Info	4-Methyl-7-[3-(4-phenyl-piperazin-1-yl)-propoxy]-chromen-2-one Show/Hide	C23H26N2O3	1
1	Ki = 18.9 nM
CP0048845 Compound Info	1-(3-chlorophenyl)-3-[2-[(1R,5S)-1-methyl-3-phenyl-6-azabicyclo[3.2.1]octan-6-yl]ethyl]imidazolidin-2-one Show/Hide	C25H30ClN3O	1
1	Ki = 19.95 nM
CP0071120 Compound Info	CHEMBL560270 Show/Hide	C23H35N3O	1
1	Ki = 19.95 nM
CP0125988 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-4-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 20 nM
CP0143982 Compound Info	N-[4-[[(1S,2S)-2-(2,3-dichlorophenyl)cyclopropyl]methyl-propylamino]butyl]naphthalene-2-carboxamide;hydrochloride Show/Hide	C28H33Cl3N2O	1
1	Ki = 20.8 nM
CP0082770 Compound Info	(-)-3-(1-Propyl-piperidin-3-yl)-phenol Show/Hide	C14H21NO	2
1	Ki = 25 nM
2	Ki = 132 nM
CP0772878 Compound Info	endo-8-(1H-Indol-3-ylmethyl)-3-(4-chlorophenyl)-8-azabicyclo-[3.2.1]octan-3-ol Show/Hide	C22H23ClN2O	1
1	Ki = 25 nM
CP0226493 Compound Info	1-(3-chlorophenyl)-3-[2-[(1S,7R)-10,10-dimethyl-4-azatricyclo[5.2.1.01,5]decan-4-yl]ethyl]imidazolidin-2-one Show/Hide	C22H30ClN3O	1
1	Ki = 25.12 nM
CP0356485 Compound Info	CHEMBL564948 Show/Hide	C23H35N3O	1
1	Ki = 25.12 nM
CP0082972 Compound Info	11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{15,20}]henicosa-1(14),3(8),4,6,15,17,19-heptaene Show/Hide	C20H22N2	1
1	Ki = 25.9 nM
CP0153919 Compound Info	2-(4-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-1H-benzoimidazole Show/Hide	C26H27ClN4O	1
1	Ki = 27 nM
CP0073485 Compound Info	1-benzyl-4-(3-hydroxyphenyl)piperazine Show/Hide	C17H20N2O	1
1	Ki = 28.9 nM
CP0113655 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-7-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 29 nM
CP0089986 Compound Info	STEPHOLIDINE Show/Hide	C19H21NO4	1
1	Ki = 30 nM
CP0129619 Compound Info	CHEMBL2203406 Show/Hide	C27H34N4O2S	1
1	Ki = 30 nM
CP0059618 Compound Info	N-[2-(4-chlorophenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C17H20ClNO2	1
1	Ki = 30.9 nM
CP0086945 Compound Info	1-[2-[1-benzothiophen-2-ylmethyl(methyl)amino]ethyl]-3-(3-chlorophenyl)imidazolidin-2-one Show/Hide	C21H22ClN3OS	1
1	Ki = 31.62 nM
CP0084819 Compound Info	(R)-5-Propylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]quinolin-2-one Show/Hide	C13H17N3O	1
1	Ki = 36 nM
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	6
1	Ki = 39 nM
2	Ki = 43 nM
3	Ki = 45 nM
4	Ki = 49 nM
5	Ki = 54 nM
6	Ki = 100 nM
CP0181488 Compound Info	CHEMBL562836 Show/Hide	C22H32FN3O	1
1	Ki = 39.81 nM
CP0059819 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-ol Show/Hide	C18H21NO	1
1	Ki = 47.5 nM
CP0226510 Compound Info	1-(3-chlorophenyl)-3-[2-[4-(4-chlorophenyl)piperidin-1-yl]ethyl]imidazolidin-2-one Show/Hide	C22H25Cl2N3O	1
1	Ki = 50.12 nM
CP0171880 Compound Info	N-[5-[4-(2-methoxyphenyl)piperazin-1-yl]pentyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C24H31N5O2	1
1	Ki = 51 nM
CP0175178 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene Show/Hide	C18H21N	1
1	Ki = 52 nM
CP0122849 Compound Info	4-(4-Benzyl-piperazin-1-yl)-1,3-dihydro-benzoimidazol-2-one Show/Hide	C18H20N4O	1
1	Ki = 56.5 nM
CP0103105 Compound Info	2-methyl-8-[3-[[4-methyl-5-(2-methylquinolin-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-6,7,9,10-tetrahydro-[1,3]oxazolo[5,4-i][3]benzazepine Show/Hide	C28H30N6OS	1
1	Ki = 63.1 nM
CP0190893 Compound Info	N-[5-[4-(2-methoxyphenyl)piperazin-1-yl]pentyl]pyrazolo[1,5-a]pyridine-3-carboxamide Show/Hide	C24H31N5O2	1
1	Ki = 64 nM
CP0424210 Compound Info	2-(4-(4-(2-methoxyphenyl)-1-piperazinyl)butyl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide Show/Hide	C21H25N3O3S	1
1	Ki = 66 nM
CP0146487 Compound Info	(2-Phenoxy-ethyl)-(3-p-tolyloxy-propyl)-amine Show/Hide	C18H23NO2	1
1	Ki = 66.07 nM
CP0059512 Compound Info	N-[2-(3,4-dimethylphenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C19H25NO2	1
1	Ki = 72.44 nM
CP0040242 Compound Info	16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene Show/Hide	C19H23NO	1
1	Ki = 75.7 nM
CP0092521 Compound Info	1-(3-chlorophenyl)-3-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]imidazolidin-2-one Show/Hide	C15H20ClN3O2	1
1	Ki = 79.43 nM
CP0266687 Compound Info	1-(2-methoxyphenyl)-4-[4-(4-phenyltriazol-1-yl)butyl]piperazine Show/Hide	C23H29N5O	1
1	Ki = 81.2 nM
CP0045385 Compound Info	CAS_15676-16-1 Show/Hide	C15H23N3O4S	1
1	Ki = 88 nM
CP0003459 Compound Info	3-(2-methoxyphenyl)-9-[3-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3,9-diazaspiro[5.5]undecane Show/Hide	C28H37N5OS	1
1	Ki = 94 nM
CP0159469 Compound Info	N-[2-(4-chlorophenoxy)ethyl]-3-(4-fluorophenoxy)propan-1-amine Show/Hide	C17H19ClFNO2	1
1	Ki = 97.72 nM
CP0092518 Compound Info	1-(3-chlorophenyl)-3-[2-(3-phenylmethoxypiperidin-1-yl)ethyl]imidazolidin-2-one Show/Hide	C23H28ClN3O2	1
1	Ki = 100 nM
CP0371905 Compound Info	2-(4-(4-(3-a,a,a-trifluorotolyl)-1-piperazinyl)butyl)-1, 2-benzisothiazole-3(2H)-one 1,1-dioxide Show/Hide	C22H24F3N3O3S	1
1	Ki = 107 nM
CP0042262 Compound Info	N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide Show/Hide	C15H23N3O4S	1
1	Ki = 120 nM
CP0049019 Compound Info	1-(3-chlorophenyl)-3-[2-[2-(3-methoxyphenyl)ethyl-methylamino]ethyl]imidazolidin-2-one Show/Hide	C21H26ClN3O2	1
1	Ki = 125.89 nM
CP0071305 Compound Info	1-(3-chlorophenyl)-3-[2-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]ethyl]imidazolidin-2-one Show/Hide	C22H28ClN3O3	1
1	Ki = 125.89 nM
CP0092519 Compound Info	1-(3-chlorophenyl)-3-[2-[methyl-[(3-methyl-1,2-oxazol-5-yl)methyl]amino]ethyl]imidazolidin-2-one Show/Hide	C17H21ClN4O2	1
1	Ki = 125.89 nM
CP0240527 Compound Info	2-(4-{3-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-1H-benzoimidazole Show/Hide	C27H30N4O2	1
1	Ki = 130 nM
CP0059535 Compound Info	(2-Phenoxy-ethyl)-(3-phenoxy-propyl)-amine Show/Hide	C17H21NO2	1
1	Ki = 134.9 nM
CP0100739 Compound Info	N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-3-carboxamide Show/Hide	C22H27N5O2	1
1	Ki = 150 nM
CP0121123 Compound Info	2-(4-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-1H-benzoimidazole Show/Hide	C26H27ClN4O	1
1	Ki = 155 nM
CP0197709 Compound Info	1-(3-chlorophenyl)-3-[2-[(1R,5S)-8-(methoxymethyl)-3-azabicyclo[3.2.1]octan-3-yl]ethyl]imidazolidin-2-one Show/Hide	C20H28ClN3O2	1
1	Ki = 158.49 nM
CP0226511 Compound Info	1-(3-chlorophenyl)-3-[2-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidin-1-yl]ethyl]imidazolidin-2-one Show/Hide	C24H26ClN5O2	1
1	Ki = 158.49 nM
CP0178983 Compound Info	(3-Phenoxy-propyl)-(2-p-tolyloxy-ethyl)-amine Show/Hide	C18H23NO2	1
1	Ki = 169.82 nM
CP0159467 Compound Info	N-[2-(4-chlorophenoxy)ethyl]-3-(4-methylphenoxy)propan-1-amine Show/Hide	C18H22ClNO2	1
1	Ki = 177.83 nM
CP0371907 Compound Info	2-(4-(4-phenyl-1-piperazinyl)butyl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide Show/Hide	C22H27N3O4S	1
1	Ki = 187 nM
CP0141761 Compound Info	(2-p-Tolyloxy-ethyl)-(3-m-tolyloxy-propyl)-amine Show/Hide	C19H25NO2	1
1	Ki = 190.55 nM
CP0059517 Compound Info	3-(4-fluorophenoxy)-N-[2-(4-methylphenoxy)ethyl]propan-1-amine Show/Hide	C18H22FNO2	1
1	Ki = 234.42 nM
CP0077361 Compound Info	4-[2-(3-Phenoxy-propylamino)-ethoxy]-phenol Show/Hide	C17H21NO3	1
1	Ki = 234.42 nM
CP0146505 Compound Info	(2-p-Tolyloxy-ethyl)-(3-p-tolyloxy-propyl)-amine Show/Hide	C19H25NO2	1
1	Ki = 234.42 nM
CP0171882 Compound Info	N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C21H25N5O2	1
1	Ki = 250 nM
CP0424213 Compound Info	2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide Show/Hide	C21H24ClN3O3S	1
1	Ki = 287 nM
CP0040250 Compound Info	2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol Show/Hide	C21H25N3O2S	4
1	Ki = 320 nM
2	Ki = 340 nM
3	Ki = 650 nM
4	Ki = 1000 nM
CP0269451 Compound Info	N-[2-(4-nitrophenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C17H20N2O4	1
1	Ki = 346.74 nM
CP0079550 Compound Info	N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]pyrazolo[1,5-a]pyridine-3-carboxamide Show/Hide	C21H25N5O2	1
1	Ki = 360 nM
CP0098943 Compound Info	N-[2-(4-methoxyphenoxy)ethyl]-3-phenoxypropan-1-amine Show/Hide	C18H23NO3	1
1	Ki = 371.54 nM
CP0059513 Compound Info	(2-p-Tolyloxy-ethyl)-(3-o-tolyloxy-propyl)-amine Show/Hide	C19H25NO2	1
1	Ki = 380.19 nM
CP0080249 Compound Info	4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one; hydrochloride Show/Hide	C20H22ClFN2O	2
1	Ki = 403.9 nM
2	Ki = 404 nM
CP0154475 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-indole Show/Hide	C19H20ClN3	1
1	Ki = 430 nM
CP0099174 Compound Info	4-[5-(4-Chloro-phenyl)-4-methyl-isoxazol-3-yl]-1-phenethyl-piperidine Show/Hide	C23H25ClN2O	1
1	Ki = 480 nM
CP0188439 Compound Info	4-(4-Benzyl-piperazin-1-yl)-5-chloro-1,3-dihydro-indol-2-one Show/Hide	C19H20ClN3O	1
1	Ki = 591.3 nM
CP0148906 Compound Info	1-(3-chlorophenyl)-3-[2-[3-(3-methoxyphenyl)piperidin-1-yl]ethyl]imidazolidin-2-one Show/Hide	C23H28ClN3O2	1
1	Ki = 630.96 nM
CP0089965 Compound Info	N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C22H27N5O2	1
1	Ki = 650 nM
CP0052140 Compound Info	7-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-4H-benzo[1,4]oxazin-3-one Show/Hide	C19H20ClN3O2	1
1	Ki = 679 nM
CP0137322 Compound Info	1H-indol-2-yl-[4-[2-(4-methoxyphenoxy)ethyl]piperazin-1-yl]methanone Show/Hide	C22H25N3O3	1
1	Ki = 1240 nM
CP0041243 Compound Info	5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride Show/Hide	C20H22ClN3O3S2	1
1	Ki = 1330 nM
CP0077364 Compound Info	3-(4-bromophenoxy)-N-[2-(4-methylphenoxy)ethyl]propan-1-amine Show/Hide	C18H22BrNO2	1
1	Ki = 1698.24 nM
CP0249081 Compound Info	2-{4-[3-(4-Methyl-piperazin-1-yl)-propoxy]-phenyl}-1H-benzoimidazole Show/Hide	C21H26N4O	1
1	Ki = 2000 nM
CP0046420 Compound Info	CAS_3853 Show/Hide	C18H19ClN4	3
1	Ki = 2300 nM
2	Ki = 2310 nM
3	Ki = 29000 nM
CP0178363 Compound Info	(R)-5-Methylamino-5,6-dihydro-1H,4H-imidazo[4,5,1-ij]quinolin-2-one Show/Hide	C11H13N3O	1
1	Ki = 2333 nM
CP0084794 Compound Info	3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyrazolo[1,5-a]pyridine Show/Hide	C18H19ClN4	1
1	Ki = 5000 nM
CP0052067 Compound Info	2-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-pyrazolo[1,5-a]pyridine Show/Hide	C18H19ClN4	2
1	Ki = 5000 nM
2	Ki = 5300 nM
CP0139431 Compound Info	(7R,9aS)-7-(4-Fluoro-phenoxymethyl)-2-(5-fluoro-pyrimidin-2-yl)-octahydro-pyrido[1,2-a]pyrazine Show/Hide	C19H22F2N4O	1
1	Ki > 2000 nM
CP0002071 Compound Info	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-prop-2-enylprop-2-en-1-amine Show/Hide	C17H22N2O	1
1	Ki < 10000 nM

Clinical Information about the Protein

Target 1 ( Dopamine D3 receptor (D3R) )

Target Type	Successful Target
Disease	8 Target-related Diseases				8
1	Bipolar disorder [ICD-11: 6A60]
2	Parkinson disease [ICD-11: 8A00.0]
3	Drug abuse [ICD-11: 6C4G.1Z]
4	Glioma [ICD-11: 2A00.0]
5	Male sexual disorder [ICD-11: HA02.0]
6	Psychotic disorder [ICD-11: 6A20-6A25]
7	Cocaine addiction [ICD-11: 6C45.2]
8	Schizophrenia [ICD-11: 6A20]
Approved Drug(s)	3 Approved Drugs				3
1	Cariprazine	Drug Info	Approved	Bipolar disorder
2	Pramipexole	Drug Info	Approved	Parkinson disease
3	Ropinirole	Drug Info	Approved	Parkinson disease
Clinical Trial Drug(s)	3 Clinical Trial Drugs				3
1	GSK598809	Drug Info	Phase 2	Drug abuse
2	ONC201	Drug Info	Phase 2	Glioma
3	GSK618334	Drug Info	Phase 1	Drug abuse
Discontinued Drug(s)	6 Discontinued Drugs				6
1	Quinelorane	Drug Info	Discontinued in Phase 3	Male sexual disorder
2	A-437203	Drug Info	Discontinued in Phase 2	Psychotic disorder
3	BP-897	Drug Info	Discontinued in Phase 2	Cocaine addiction
4	S-33138	Drug Info	Discontinued in Phase 1	Psychotic disorder
5	BP4.879a	Drug Info	Terminated	Schizophrenia
6	YM-43611	Drug Info	Terminated	Psychotic disorder
Investigative Drug(s)	1 Investigative Drug				1
1	A-690344	Drug Info	Investigative	Schizophrenia
Preclinical Drug(s)	4 Preclinical Drugs				4
1	F-15063	Drug Info	Preclinical	Schizophrenia
2	PD-157695	Drug Info	Preclinical	Schizophrenia
3	S-33084	Drug Info	Preclinical	Psychotic disorder
4	S32504	Drug Info	Preclinical	Parkinson disease

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