General Information of the Compound
Compound ID
CP0226491
Compound Name
1-(3-chlorophenyl)-3-[2-(4,6,7,8-tetrahydrothieno[3,2-c]azepin-5-yl)ethyl]imidazolidin-2-one
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Structure
Formula
C19H22ClN3OS
Molecular Weight
375.925
Canonical SMILES
Clc1cccc(c1)N1CCN(CCN2CCCc3sccc3C2)C1=O
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InChI
InChI=1S/C19H22ClN3OS/c20-16-3-1-4-17(13-16)23-11-10-22(19(23)24)9-8-21-7-2-5-18-15(14-21)6-12-25-18/h1,3-4,6,12-13H,2,5,7-11,14H2
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InChIKey
KAEBDVFJWYJWBA-UHFFFAOYSA-N
Physicochemical Property
logP
4.0919
Rotatable Bonds
4
Heavy Atom Count
25
Polar Areas
26.79
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45267491
ChEMBL ID
CHEMBL559873
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.162 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 3.162 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 0.631 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.631 nM