General Information of the Compound
Compound ID
CP0424213
Compound Name
2-(4-(4-(4-chlorophenyl)-1-piperazinyl)butyl)-1,2-benzisothiazole-3(2H)-one 1,1-dioxide
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Structure
Formula
C21H24ClN3O3S
Molecular Weight
433.961
Canonical SMILES
Clc1ccc(cc1)N1CCN(CCCCN2C(=O)c3ccccc3S2(=O)=O)CC1
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InChI
InChI=1S/C21H24ClN3O3S/c22-17-7-9-18(10-8-17)24-15-13-23(14-16-24)11-3-4-12-25-21(26)19-5-1-2-6-20(19)29(25,27)28/h1-2,5-10H,3-4,11-16H2
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InChIKey
AEKRAVIJSVJVBT-UHFFFAOYSA-N
Physicochemical Property
logP
3.0869
Rotatable Bonds
6
Heavy Atom Count
29
Polar Areas
60.93
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44436301
ChEMBL ID
CHEMBL238915
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 177 nM
   TI
   LI
   LO
   TS
2
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 287 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 287 nM