General Information of the Compound
Compound ID
CP0417213
Compound Name
6-[(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)(propyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
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Structure
Formula
C26H37N3O2
Molecular Weight
423.601
Canonical SMILES
CCCN(CCN1CCN(CC1)c1ccccc1OC)C1CCc2c(O)cccc2C1
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InChI
InChI=1S/C26H37N3O2/c1-3-13-28(22-11-12-23-21(20-22)7-6-9-25(23)30)17-14-27-15-18-29(19-16-27)24-8-4-5-10-26(24)31-2/h4-10,22,30H,3,11-20H2,1-2H3
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InChIKey
ZGSHIAJEAFZHNC-UHFFFAOYSA-N
Physicochemical Property
logP
3.7923
Rotatable Bonds
8
Heavy Atom Count
31
Polar Areas
39.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24754400
ChEMBL ID
CHEMBL399164
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 1.56 nM
   TI
   LI
   LO
   TS
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000367 AtT-20 Mus musculus (Mouse)  1
1
EC50 = 0.08 nM
   TI
   LI
   LO
   TS