General Information of the Compound
Compound ID
CP0226493
Compound Name
1-(3-chlorophenyl)-3-[2-[(1S,7R)-10,10-dimethyl-4-azatricyclo[5.2.1.01,5]decan-4-yl]ethyl]imidazolidin-2-one
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Structure
Formula
C22H30ClN3O
Molecular Weight
387.955
Canonical SMILES
CC1(C)[C@@H]2CC[C@]11CCN(CCN3CCN(C3=O)c3cccc(Cl)c3)C1C2
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InChI
InChI=1S/C22H30ClN3O/c1-21(2)16-6-7-22(21)8-9-24(19(22)14-16)10-11-25-12-13-26(20(25)27)18-5-3-4-17(23)15-18/h3-5,15-16,19H,6-14H2,1-2H3/t16-,19?,22-/m1/s1
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InChIKey
BLMDJHOZZKURJN-ZDUIXAHXSA-N
Physicochemical Property
logP
4.4826
Rotatable Bonds
4
Heavy Atom Count
27
Polar Areas
26.79
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45267492
ChEMBL ID
CHEMBL562833
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 316.23 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 316.23 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 25.12 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 25.12 nM