General Information of the Compound
Compound ID
CP0181488
Compound Name
CHEMBL562836
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Formula
C22H32FN3O
Molecular Weight
373.516
Canonical SMILES
CN(CCN1CCN(C1=O)c1ccc(F)cc1)C[C@@]12CC[C@@H](CC1)C2(C)C
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InChI
InChI=1S/C22H32FN3O/c1-21(2)17-8-10-22(21,11-9-17)16-24(3)12-13-25-14-15-26(20(25)27)19-6-4-18(23)5-7-19/h4-7,17H,8-16H2,1-3H3/t17-,22+
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InChIKey
MLUVBFQPCVSGBZ-LMTLIKQPSA-N
Physicochemical Property
logP
4.2159
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
26.79
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL562836
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 630.96 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 630.96 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 39.81 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 39.81 nM