General Information of the Compound
Compound ID
CP0194254
Compound Name
4-(1H-imidazol-1-yl)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)benzamide
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Structure
Formula
C25H31N5O2
Molecular Weight
433.556
Canonical SMILES
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(cc2)-n2ccnc2)CC1
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InChI
InChI=1S/C25H31N5O2/c1-32-24-7-3-2-6-23(24)29-18-16-28(17-19-29)14-5-4-12-27-25(31)21-8-10-22(11-9-21)30-15-13-26-20-30/h2-3,6-11,13,15,20H,4-5,12,14,16-19H2,1H3,(H,27,31)
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InChIKey
NTASTGHPPLINPW-UHFFFAOYSA-N
Physicochemical Property
logP
3.2131
Rotatable Bonds
9
Heavy Atom Count
32
Polar Areas
62.63
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11568232
SID: 16670516
ChEMBL ID
CHEMBL201270
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000049 C6 Rattus norvegicus (Rat)  1
1
Ki = 27.2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 51.7 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4.79 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 4.23 nM