General Information of the Compound
Compound ID
CP0057009
Compound Name
1-[2-[(1R,10S)-11-azatricyclo[8.2.2.03,8]tetradeca-3,5,7-trien-11-yl]ethyl]-3-(3-chlorophenyl)imidazolidin-2-one
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Structure
Formula
C24H28ClN3O
Molecular Weight
409.961
Canonical SMILES
Clc1cccc(c1)N1CCN(CCN2C[C@@H]3CC[C@H]2Cc2ccccc2C3)C1=O
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InChI
InChI=1S/C24H28ClN3O/c25-21-6-3-7-23(16-21)28-13-12-26(24(28)29)10-11-27-17-18-8-9-22(27)15-20-5-2-1-4-19(20)14-18/h1-7,16,18,22H,8-15,17H2/t18-,22+/m1/s1
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InChIKey
IMFBORACXDJQCD-GCJKJVERSA-N
Physicochemical Property
logP
4.4614
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
26.79
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45267480
ChEMBL ID
CHEMBL562464
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 25.12 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 25.12 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2.512 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 2.512 nM