General Information of the Compound
Compound ID
CP0121123
Compound Name
2-(4-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-1H-benzoimidazole
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Structure
Formula
C26H27ClN4O
Molecular Weight
446.982
Canonical SMILES
Clc1cccc(c1)N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3[nH]2)CC1
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InChI
InChI=1S/C26H27ClN4O/c27-21-5-3-6-22(19-21)31-16-14-30(15-17-31)13-4-18-32-23-11-9-20(10-12-23)26-28-24-7-1-2-8-25(24)29-26/h1-3,5-12,19H,4,13-18H2,(H,28,29)
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InChIKey
KHGQUBQJPRFGKU-UHFFFAOYSA-N
Physicochemical Property
logP
5.4744
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
44.39
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 15817169
ChEMBL ID
CHEMBL84819
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1403 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1403 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 155 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 155 nM