General Information of the Compound
Compound ID
CP0302329
Compound Name
1-[2-[(1R,5S)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-3-(3-chlorophenyl)imidazolidin-2-one
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Structure
Formula
C18H24ClN3O
Molecular Weight
333.863
Canonical SMILES
Clc1cccc(c1)N1CCN(CCN2[C@H]3CC[C@@H]2CCC3)C1=O
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InChI
InChI=1S/C18H24ClN3O/c19-14-3-1-6-17(13-14)22-12-10-20(18(22)23)9-11-21-15-4-2-5-16(21)8-7-15/h1,3,6,13,15-16H,2,4-5,7-12H2/t15-,16+
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InChIKey
VXTVAYBBRGJBTM-IYBDPMFKSA-N
Physicochemical Property
logP
3.5989
Rotatable Bonds
4
Heavy Atom Count
23
Polar Areas
26.79
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45273522
ChEMBL ID
CHEMBL563580
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5.012 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 5.012 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.259 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.259 nM