General Information of the Compound
Compound ID
CP0042262
Compound Name
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
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Synonyms
(+/-)-Sulpiride
(RS)-(+/-)-sulpiride
(inverted question mark)-Sulpiride
Abilit
Aiglonyl
Alimoral
Allphar Brand of Sulpiride
Almirall Brand of Sulpiride
Areu Brand of Sulpiride
Arminol
Bosnyl (TN)
Calmoflorine
Centrum Brand of Sulpiride
Championyl
Coolspan
Darleton
Deponerton
Desisulpid
Desitin Brand of Sulpiride
Desmenat
Digton
Dobren
Dogmatil
Dogmatil (TN)
Dogmatyl
Dogmatyl (TN)
Dolmatil
Dolorgiet Brand of Sulpiride
Dresent
Eglonil
Eglonyl
Eglonyl (TN)
Ekilid
Enimon
Equilid
Erempharma Brand of Sulpiride
Eusulpid
Fardalan
Fidelan
Fumouzer Brand of Sulpiride
Guastil
Hennig Brand of Sulpiride
Hexal Brand of Sulpiride
Hoechst Brand of Sulpiride
Hormosan Brand of Sulpiride
Isnamide
Krewel Brand of Sulpiride
Kylistro
Lebopride
Levobren
Levopraid
Levosulpirida
Levosulpirida [INN-Spanish]
Levosulpiride [INN]
Levosulpiridum
Levosulpiridum [INN-Latin]
Lisopiride
Magnetic resonance imaging sulpiride
Mariastel
Meresa
Meresa (TN)
Miradol
Mirbanil
Misulvan
N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide
Neogama
Neuraxpharm (TN)
Norestran
Normum
Nufarol
Omiryl
Omperan
Ozoderpin
Pharmacia Brand of Sulpiride
Pontiride
Psicocen
Psicofarma Brand of Sulpiride
Pyrikappl
Pyrkappl
R. D. 1403
R.D. 1403
RD 1403
RV-12309
Ratiopharm (TN)
Restful
Rosemont Brand of Sulpiride
S 8010
Sanofi Synthelabo Brand of Sulpiride
Sanofi-Synthelabo Brand of Sulpiride
Sernevin
Splotin
Spyfarma Brand of Sulpiride
Stamonevrol
Sulp
Sulperide
Sulpirid
Sulpirid (TN)
Sulpirida
Sulpirida [INN-Spanish]
Sulpiride
Sulpiride (JP15/USAN/INN)
Sulpiride [USAN:INN:BAN:JAN]
Sulpiridum
Sulpiridum [INN-Latin]
Sulpiryd (TN)
Sulpitil
Sulpivert
Sulpor
Sulpride
Sulpyrid
Suprium
Sursumid
Synedil
Tepavil
Uriach Brand of Sulpiride
Valirem
Vertigo Meresa
Vertigo neogama
Vertigo-Meresa
Vertigo-neogama
Zemorcon
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Structure
Formula
C15H23N3O4S
Molecular Weight
341.433
Canonical SMILES
CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
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InChI
InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
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InChIKey
BGRJTUBHPOOWDU-UHFFFAOYSA-N
CAS
15676-16-1
23672-07-3
Physicochemical Property
logP
0.5567
Rotatable Bonds
6
Heavy Atom Count
23
Polar Areas
101.73
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 5355
SID: 14802423
ChEMBL ID
CHEMBL26
DrugBank ID
DB00391
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00209, Carbonic anhydrase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 430 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 430 nM
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000153 CHOP Cricetulus griseus (Chinese hamster)  1
1
IC50 = 10.28 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
2
Kd = 2.818 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 7.6 nM
2 Ki = 9.8 nM
3 Ki = 120 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000153 CHOP Cricetulus griseus (Chinese hamster)  1
1
IC50 = 66.22 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  2
1
IC50 = 560 nM
   TI
   LI
   LO
   TS
2
Kd = 39.81 nM
   TI
   LI
   LO
   TS
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 120 nM
Clinical Information about the Compound
Drug 1 ( Sulpiride )
Drug Name Sulpiride
Company Arrow Generics
Indication
Schizophrenia
Approved
Target(s)
Dopamine D2 receptor (D2R)
Antagonist