General Information of the Compound
Compound ID
CP0153901
Compound Name
2-(4-{3-[4-(2-Propylsulfanyl-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-1H-benzoimidazole
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Structure
Formula
C29H34N4OS
Molecular Weight
486.685
Canonical SMILES
CCCSc1ccccc1N1CCN(CCCOc2ccc(cc2)-c2nc3ccccc3[nH]2)CC1
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InChI
InChI=1S/C29H34N4OS/c1-2-22-35-28-11-6-5-10-27(28)33-19-17-32(18-20-33)16-7-21-34-24-14-12-23(13-15-24)29-30-25-8-3-4-9-26(25)31-29/h3-6,8-15H,2,7,16-22H2,1H3,(H,30,31)
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InChIKey
YEBWFZBYQOGEEH-UHFFFAOYSA-N
Physicochemical Property
logP
6.3231
Rotatable Bonds
10
Heavy Atom Count
35
Polar Areas
44.39
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10074155
SID: 15059621
ChEMBL ID
CHEMBL87478
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 8 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 1.3 nM