General Information of the Compound
Compound ID
CP0092523
Compound Name
1-(3-chlorophenyl)-3-[2-[(1S,5R)-1,8,8-trimethyl-3-azabicyclo[3.2.1]octan-3-yl]ethyl]imidazolidin-2-one
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Structure
Formula
C21H30ClN3O
Molecular Weight
375.944
Canonical SMILES
CC1(C)[C@H]2CC[C@]1(C)CN(CCN1CCN(C1=O)c1cccc(Cl)c1)C2
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InChI
InChI=1S/C21H30ClN3O/c1-20(2)16-7-8-21(20,3)15-23(14-16)9-10-24-11-12-25(19(24)26)18-6-4-5-17(22)13-18/h4-6,13,16H,7-12,14-15H2,1-3H3/t16-,21+/m0/s1
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InChIKey
HWLQRSMZQWZHLO-HRAATJIYSA-N
Physicochemical Property
logP
4.3401
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
26.79
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45272616
ChEMBL ID
CHEMBL564930
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01005, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 31.62 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 31.62 nM
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 15.85 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 15.85 nM