Protein Information

General Information of the Protein

Protein ID	PT01195
Protein Name	D(1A) dopamine receptor
Secondarily Protein Name	Dopamine D1 receptor
Gene Name	DRD1
Sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Dopamine receptor
Function	Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Show/Hide
Uniprot ID	Primary ID: P21728 Secondarily ID: B2RA44 Q4QRJ0 Show/Hide
HGNC ID	HGNC:3020
Subcellular Location	Cell membrane Endoplasmic reticulum membrane Cell projection Cilium membrane Cell projection Dendrite Cell projection Dendritic spine

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000053 , COS-7

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0036551 Compound Info	9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid Show/Hide	C16H16ClNO3	1
1	Kd = 28 nM Bioactivity Info	TI LI LO TS
CP0087918 Compound Info	(R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol Show/Hide	C16H17NO2	1
1	Kd = 150 nM Bioactivity Info	TI LI LO TS
CP0232734 Compound Info	(R)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepinium Show/Hide	C19H20BrNO2	1
1	Kd = 384 nM Bioactivity Info	TI LI LO TS
CP0042751 Compound Info	(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrate;hydrochloride Show/Hide	C17H17NO2	1
1	Kd = 680 nM Bioactivity Info	TI LI LO TS
CP0118587 Compound Info	6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol; hydrochloride Show/Hide	C19H21NO2	1
1	Kd = 1816 nM Bioactivity Info	TI LI LO TS
CP0658310 Compound Info	SID124880138 Show/Hide	C16H16ClNO3	1
1	Kd = 1818 nM Bioactivity Info	TI LI LO TS
CP0036921 Compound Info	3-HYDROXYTYRAMINE HYDROCHLORIDE Show/Hide	C8H11NO2	1
1	Kd = 2500 nM Bioactivity Info	TI LI LO TS
CP0699735 Compound Info	(6,7-Dihydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dimethyl-ammonium Show/Hide	C12H17NO2	1
1	Kd = 4600 nM Bioactivity Info	TI LI LO TS
CP0001238 Compound Info	14C-5-hydroxy tryptamine creatinine disulfate Show/Hide	C10H12N2O	1
1	Kd = 9690 nM Bioactivity Info	TI LI LO TS
CP0039930 Compound Info	(-)-arterenol Show/Hide	C8H11NO3	1
1	Kd = 50000 nM Bioactivity Info	TI LI LO TS
CP0042352 Compound Info	2,3-bis(oxidanyl)butanedioic acid;4-[(1R)-2-(methylamino)-1-oxidanyl-ethyl]benzene-1,2-diol Show/Hide	C9H13NO3	1
1	Kd = 55000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000041 , LTK-

Cell Line Info

Cell Line ID: CL000074 , SK-N-MC

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0064183 Compound Info	4-[3-methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy]furo[3,2-c]pyridine Show/Hide	C21H16N4O2	1
1	EC50 = 17 nM
CP0240209 Compound Info	4-[3-methyl-4-(2-methylimidazo[4,5-c]pyridin-1-yl)phenoxy]furo[3,2-c]pyridine Show/Hide	C21H16N4O2	1
1	EC50 = 153 nM
CP0113847 Compound Info	(+/-)-SKF-38393 Show/Hide	C16H17NO2	1
1	EC50 = 247.5 nM
CP0177109 Compound Info	4-[4-(2-methylpyrazol-3-yl)phenoxy]furo[3,2-c]pyridine Show/Hide	C17H13N3O2	1
1	EC50 = 2519 nM
CP0680677 Compound Info	(R)-8-chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol maleate Show/Hide	C21H22ClNO5	3
1	IC50 = 0.22 nM
2	IC50 = 0.27 nM
3	Ki = 0.11 nM
CP0046341 Compound Info	8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol(SCH 23390) Show/Hide	C17H18ClNO	10
1	IC50 = 0.66 nM
2	IC50 = 0.74 nM
3	IC50 = 0.82 nM
4	IC50 = 0.96 nM
5	Ki = 0.11 nM
6	Ki = 0.2 nM
7	Ki = 0.3 nM
8	Ki = 0.38 nM
9	Ki = 0.4266 nM
10	Ki = 1.4 nM
CP0385103 Compound Info	CAS_87075-17-0 Show/Hide	C17H18ClNO	1
1	IC50 = 740 nM
CP0272712 Compound Info	(13aS)-3,9,11-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-2-ol Show/Hide	C20H23NO4	1
1	IC50 = 1400 nM
CP0272711 Compound Info	US9359372, DC037030 Show/Hide	C20H23NO4	1
1	IC50 = 1900 nM
CP0059819 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaen-6-ol Show/Hide	C18H21NO	3
1	Ki = 0.3548 nM
2	Ki = 0.39 nM
3	Ki = 0.4 nM
CP0338716 Compound Info	1-Chloro-2-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H20ClNO	1
1	Ki = 0.46 nM
CP0298952 Compound Info	7-methyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][3]benzazecin-11-ol Show/Hide	C20H22N2O	1
1	Ki = 0.5623 nM
CP0165743 Compound Info	4-Chloro-3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H20ClNO	2
1	Ki = 0.8128 nM
2	Ki = 0.83 nM
CP0046343 Compound Info	(6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahydro-6H-7-aza-benzo[6,7]cyclohepta[1,2-a]naphthalen-12-ol Show/Hide	C19H20ClNO	3
1	Ki = 0.9 nM
2	Ki = 1.2 nM
3	Ki = 1.9 nM
CP0118587 Compound Info	6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol; hydrochloride Show/Hide	C19H21NO2	3
1	Ki = 1 nM
2	Ki = 490 nM
3	Ki = 1510 nM
CP0087918 Compound Info	(R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol Show/Hide	C16H17NO2	3
1	Ki = 1 nM
2	Ki = 73 nM
3	Ki = 320 nM
CP0082972 Compound Info	11-methyl-11,21-diazatetracyclo[12.7.0.0^{3,8}.0^{15,20}]henicosa-1(14),3(8),4,6,15,17,19-heptaene Show/Hide	C20H22N2	3
1	Ki = 1.862 nM
2	Ki = 1.9 nM
3	Ki < 10 nM
CP0099064 Compound Info	3,11-Dihydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H21NO2	1
1	Ki = 2 nM
CP0037230 Compound Info	8-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g][4]benzazacycloundecine Show/Hide	C21H24N2	1
1	Ki = 2.042 nM
CP0232734 Compound Info	(R)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepinium Show/Hide	C19H20BrNO2	1
1	Ki = 3 nM
CP0059813 Compound Info	3-Chloro-2-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H20ClNO	1
1	Ki = 3.1 nM
CP0059816 Compound Info	2,4-dichloro-3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H19Cl2NO	1
1	Ki = 3.2 nM
CP0175178 Compound Info	11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene Show/Hide	C18H21N	2
1	Ki = 3.467 nM
2	Ki = 4.5 nM
CP0074631 Compound Info	6-methyl-4,5,6,7,8,13-hexahydrothieno[2,3-f][3]benzazecine Show/Hide	C16H19NS	1
1	Ki = 4 nM
CP0042751 Compound Info	(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrate;hydrochloride Show/Hide	C17H17NO2	2
1	Ki = 4.6 nM
2	Ki = 650 nM
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	6
1	Ki = 6.166 nM
2	Ki = 49 nM
3	Ki = 82 nM
4	Ki = 107 nM
5	Ki = 120 nM
6	Ki = 270 nM
CP0037328 Compound Info	(6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydro-benzo[a]phenanthridinium Show/Hide	C17H17NO2	2
1	Ki = 6.2 nM
2	Ki = 1200 nM
CP0044469 Compound Info	(1S)-16-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaen-17-ol Show/Hide	C19H19NO4	1
1	Ki = 6.5 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	9
1	Ki = 7.5 nM
2	Ki = 21.38 nM
3	Ki = 31.62 nM
4	Ki = 44 nM
5	Ki = 53 nM
6	Ki = 180 nM
7	Ki = 290 nM
8	Ki = 540 nM
9	Ki = 1000 nM
CP0059820 Compound Info	1-methoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C19H23NO	1
1	Ki = 7.6 nM
CP0059821 Compound Info	1-Hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H21NO	1
1	Ki = 8.7 nM
CP0155138 Compound Info	2-Hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H21NO	1
1	Ki = 8.9 nM
CP0162167 Compound Info	2-Amino-3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C18H22N2O	1
1	Ki = 9.3 nM
CP0186639 Compound Info	3,11-Dimethoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C20H25NO2	1
1	Ki = 9.4 nM
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	6
1	Ki = 10 nM
2	Ki = 47 nM
3	Ki = 52 nM
4	Ki = 100 nM
5	Ki = 119 nM
6	Ki = 250 nM
CP0258036 Compound Info	5-(2-chlorophenyl)-8-methoxy-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Show/Hide	C18H20ClNO2	1
1	Ki = 14 nM
CP0040242 Compound Info	16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene Show/Hide	C19H23NO	2
1	Ki = 22.91 nM
2	Ki = 28.5 nM
CP0141367 Compound Info	1,3-Dichloro-2-methoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C19H21Cl2NO	1
1	Ki = 25.3 nM
CP0263495 Compound Info	(5R)-9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol Show/Hide	C16H16ClNO2	1
1	Ki = 30 nM
CP0036551 Compound Info	9-chloranyl-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid Show/Hide	C16H16ClNO3	1
1	Ki = 40 nM
CP0181209 Compound Info	(-)-Tetrahydroberberine Show/Hide	C20H21NO4	1
1	Ki = 48.6 nM
CP0059815 Compound Info	2-methoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine Show/Hide	C19H23NO	1
1	Ki = 82 nM
CP0061859 Compound Info	(+/-)-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline Show/Hide	C16H15NO3	1
1	Ki = 98 nM
CP0169939 Compound Info	(-)-Corydalmine Show/Hide	C20H23NO4	1
1	Ki = 107 nM
CP0127660 Compound Info	7-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g][3]benzazacycloundecine Show/Hide	C21H24N2	1
1	Ki = 158.49 nM
CP0036921 Compound Info	3-HYDROXYTYRAMINE HYDROCHLORIDE Show/Hide	C8H11NO2	2
1	Ki = 192 nM
2	Ki = 18200 nM
CP0126302 Compound Info	(13aS)-2,9,10-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-3-ol Show/Hide	C20H23NO4	1
1	Ki = 199 nM
CP0315086 Compound Info	3-chloro-6-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-11H-benzo[b][1,4]benzodiazepine Show/Hide	C19H18ClN3	1
1	Ki = 380 nM
CP0078330 Compound Info	7-[4-[4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one Show/Hide	C24H29Cl2N3O2	1
1	Ki = 825 nM
CP0042927 Compound Info	7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one Show/Hide	C23H27Cl2N3O2	2
1	Ki = 895 nM
2	Ki = 1000 nM
CP0045034 Compound Info	N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-2-carboxamide Show/Hide	C23H29N5O2	1
1	Ki = 1500 nM
CP0050995 Compound Info	(6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol Show/Hide	C19H21NO	1
1	Ki = 4300 nM
CP0699735 Compound Info	(6,7-Dihydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dimethyl-ammonium Show/Hide	C12H17NO2	1
1	Ki = 5400 nM
CP0038689 Compound Info	(4aS,5R,10bR)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol Show/Hide	C19H21NO2	1
1	Ki = 18000 nM

Clinical Information about the Protein

Target 1 ( Dopamine D1 receptor (D1R) )

Target Type	Successful Target
Disease	8 Target-related Diseases				8
1	Hypertension [ICD-11: BA00-BA04]
2	Spontaneous abortion [ICD-11: JA00.0]
3	Parkinson disease [ICD-11: 8A00.0]
4	Allergy [ICD-11: 4A80-4A85]
5	Cocaine addiction [ICD-11: 6C45.2]
6	Schizophrenia [ICD-11: 6A20]
7	Pain [ICD-11: MG30-MG3Z]
8	Type-2 diabetes [ICD-11: 5A11]
Approved Drug(s)	4 Approved Drugs				4
1	Fenoldopam	Drug Info	Approved	Hypertension
2	Methylergonovine	Drug Info	Approved	Spontaneous abortion
3	Pergolide	Drug Info	Approved	Parkinson disease
4	Phenyltoloxamine	Drug Info	Approved	Allergy
Clinical Trial Drug(s)	2 Clinical Trial Drugs				2
1	Ecopipam	Drug Info	Phase 3	Cocaine addiction
2	Zicronapine	Drug Info	Phase 3	Schizophrenia
Discontinued Drug(s)	5 Discontinued Drugs				5
1	CY-208243	Drug Info	Discontinued in Phase 2	Pain
2	A 77636	Drug Info	Terminated	Parkinson disease
3	A-68930	Drug Info	Terminated	Hypertension
4	SKF 38393	Drug Info	Terminated	Type-2 diabetes
5	SKF-81297	Drug Info	Terminated	Parkinson disease

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT04612	D(1B) dopamine receptor	Rattus norvegicus, Rat	Protein Info
PT07597	D(1B) dopamine receptor	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han