General Information of the Protein
Protein ID
PT01366
Protein Name
D(3) dopamine receptor
Secondarily
Protein Name
Dopamine D3 receptor
Gene Name
DRD3
Sequence
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Function
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity).
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Uniprot ID
Primary ID:
P19020

Secondarily ID:
P70647
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Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000026 , CHO-K1
Compound ID Compound Name Compound Formula
CP0372431
3-Naphthalen-1-yl-pyrrolidine
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C14H15N
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0372532
3-(1-Propyl-pyrrolidin-3-yl)-pyridine
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C12H18N2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0392192
3-(3-methylsulfonylphenyl)pyrrolidine
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C11H15NO2S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0440941
3-(3-Methanesulfonyl-phenyl)-1-propyl-pyrrolidine
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C14H21NO2S
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0448901
3-Cyclohexyl-1-propyl-pyrrolidine
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C13H25N
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0497809
3-Naphthalen-1-yl-1-propyl-pyrrolidine
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C17H21N
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0506111
5-(1-Methyl-pyrrolidin-3-yl)-3,4-dihydro-pyridine
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C10H16N2
 1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
CP0213935
3-Phenyl-pyrrolidine
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C10H13N
 1
1
IC50 > 2440 nM
   TI
   LI
   LO
   TS
CP0393208
(4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
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C18H25FN2
 1
1
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CP0383969
((S)-4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
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C18H25FN2
 1
1
Ki = 4.1 nM
   TI
   LI
   LO
   TS
CP0492002
((R)-4-Fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
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C18H25FN2
 1
1
Ki = 14 nM
   TI
   LI
   LO
   TS
CP0348071
(1-Chloro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
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C18H25ClN2
 1
1
Ki = 15 nM
   TI
   LI
   LO
   TS
CP0216619
(8S)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine
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C18H26N2
 1
1
Ki = 22 nM
   TI
   LI
   LO
   TS
CP0378932
8-Dipropylamino-1,3,6,7,8,9-hexahydro-benzo[e]indol-2-one
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C18H26N2O
 1
1
Ki = 23 nM
   TI
   LI
   LO
   TS
CP0056626
(8R)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine
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C18H26N2
 1
1
Ki = 30 nM
   TI
   LI
   LO
   TS
CP0372510
1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine
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C14H18F3N
 1
1
Ki = 35 nM
   TI
   LI
   LO
   TS
CP0258010
(+/-)-Dipropyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine
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C18H26N2
 1
1
Ki = 37 nM
   TI
   LI
   LO
   TS
CP0043151
8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile
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C19H25N3
 1
1
Ki = 43 nM
   TI
   LI
   LO
   TS
CP0065057
(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile
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C19H25N3
 1
1
Ki = 45 nM
   TI
   LI
   LO
   TS
CP0276816
(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde
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C19H26N2O
 1
1
Ki = 51 nM
   TI
   LI
   LO
   TS
CP0495965
(4-Fluoro-3-methyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
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C19H27FN2
 1
1
Ki = 52 nM
   TI
   LI
   LO
   TS
CP0115861
3-(1-Propyl-pyrrolidin-3-yl)-phenol
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C13H19NO
 1
1
Ki = 52 nM
   TI
   LI
   LO
   TS
CP0393093
(R)-8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde
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C19H25FN2O
 1
1
Ki = 55 nM
   TI
   LI
   LO
   TS
CP0384127
(1-Methylsulfanyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
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C19H28N2S
 1
1
Ki = 55 nM
   TI
   LI
   LO
   TS
CP0447225
[3-(1-propylpyrrolidin-3-yl)phenyl] trifluoromethanesulfonate
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C14H18F3NO3S
 1
1
Ki = 62 nM
   TI
   LI
   LO
   TS
CP0393274
8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile
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C19H24FN3
 1
1
Ki = 63 nM
   TI
   LI
   LO
   TS
CP0373268
(1-Methyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
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C19H28N2
 1
1
Ki = 67 nM
   TI
   LI
   LO
   TS
CP0052478
(+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde
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C19H26N2O
 1
1
Ki = 70 nM
   TI
   LI
   LO
   TS
CP0404397
2-Fluoro-N*6*,N*6*-dipropyl-5,6,7,8-tetrahydro-naphthalene-1,6-diamine
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C16H25FN2
 1
1
Ki = 77 nM
   TI
   LI
   LO
   TS
CP0425321
(S)-8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde
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C19H25FN2O
 1
1
Ki = 78 nM
   TI
   LI
   LO
   TS
CP0377149
(8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-phenyl-methanone
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C25H30N2O
 1
1
Ki = 108 nM
   TI
   LI
   LO
   TS
CP0500731
(4-Fluoro-1-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
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C21H31FN2
 1
1
Ki = 111 nM
   TI
   LI
   LO
   TS
CP0430125
1-(8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-ethanone
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C20H28N2O
 1
1
Ki = 320 nM
   TI
   LI
   LO
   TS
CP0037227
7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
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C16H25NO
 1
1
Ki = 333 nM
   TI
   LI
   LO
   TS
CP0099933
(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile
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C19H25N3
 1
1
Ki = 391 nM
   TI
   LI
   LO
   TS
CP0503251
1-(8-Dipropylamino-4-fluoro-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-propan-1-one
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C21H29FN2O
 1
1
Ki = 542 nM
   TI
   LI
   LO
   TS
CP0490333
3-[3-(trifluoromethyl)phenyl]pyrrolidine
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C11H12F3N
 1
1
Ki = 633 nM
   TI
   LI
   LO
   TS
CP0497094
1-(8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indol-1-yl)-2,2,2-trifluoro-ethanone
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C20H25F3N2O
 1
1
Ki = 675 nM
   TI
   LI
   LO
   TS
CP0221880
(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde
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C19H26N2O
 1
1
Ki = 751 nM
   TI
   LI
   LO
   TS
CP0393209
8-Dipropylamino-3-methyl-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde
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C20H28N2O
 1
1
Ki = 1012 nM
   TI
   LI
   LO
   TS
CP0448191
(S)-3-(3-Methoxy-phenyl)-1-propyl-piperidine
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C15H23NO
 1
1
Ki = 1328 nM
   TI
   LI
   LO
   TS
CP0397973
3-Phenyl-1-propyl-pyrrolidine
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C13H19N
 1
1
Ki > 2500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0006107
CAS_85760-74-3
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C13H21N3
 1
1 EC50 = 80 nM
CP0035955
(R,S) 7-[(3-Iodo-allyl)-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol
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C16H22INO
 2
1 Kd = 0.13 nM
2 Ki = 1.85 nM
CP0162854
(+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
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C16H25NO
 2
1 Kd = 0.67 nM
2 Ki = 2.9 nM
CP0127400
(-)-Pramipexole
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C10H17N3S
 2
1 Ki = 0.45 nM
2 Ki = 0.78 nM
CP0110281
Biphenyl-4-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide
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C27H29Cl2N3O
 1
1 Ki = 1.15 nM
CP0772206
SID56463240
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C26H32ClN3O2
 1
1 Ki = 1.2 nM
CP0116811
5-Bromo-N-{4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-2,3-dimethoxy-benzamide
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C23H28BrCl2N3O3
 1
1 Ki = 2 nM
CP0008601
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)
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C21H23ClFNO2
 2
1 Ki = 3 nM
2 Ki = 28 nM
CP0048757
4-Bromo-1-methoxy-naphthalene-2-carboxylic acid {4-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-butyl}-amide
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C26H28BrCl2N3O2
 1
1 Ki = 4.97 nM
CP0025667
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
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C18H19ClN4
 1
1 Ki = 500 nM