Protein Information

General Information of the Protein

Protein ID	PT01266
Protein Name	Muscarinic acetylcholine receptor M3
Gene Name	CHRM3
Sequence	MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Acetylcholine receptor
Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Show/Hide
Uniprot ID	Primary ID: P20309 Secondarily ID: Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 Show/Hide
Ensembl ID	ENSG00000133019
HGNC ID	HGNC:1952
Subcellular Location	Cell membrane Postsynaptic cell membrane Basolateral cell membrane Endoplasmic reticulum membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000398 , A-9

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0635477 Compound Info	(2-Carbamoyloxy-ethyl)-trimethyl-ammonium chloride Show/Hide	C6H15ClN2O2	2
1	EC50 = 5011.87 nM Bioactivity Info	TI LI LO TS
2	Ki = 6309.57 nM Bioactivity Info	TI LI LO TS
CP0371787 Compound Info	5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid Show/Hide	C14H23N3OS	2
1	EC50 = 25118.86 nM Bioactivity Info	TI LI LO TS
2	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0376259 Compound Info	1-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]-2-[2-(2-{2-[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]ethoxy}ethoxy)ethoxy]ethane Show/Hide	C24H36N6O5S2	1
1	Ki = 5.012 nM Bioactivity Info	TI LI LO TS
CP0176132 Compound Info	11-[2-[4-[4-(diethylamino)butyl]piperidin-1-yl]acetyl]-5H-benzo[b][1,4]benzodiazepin-6-one Show/Hide	C28H38N4O2	1
1	Ki = 10 nM Bioactivity Info	TI LI LO TS
CP0179471 Compound Info	3-methoxy-4-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole Show/Hide	C19H29N5O6S2	1
1	Ki = 25.12 nM Bioactivity Info	TI LI LO TS
CP0847519 Compound Info	5-{4-[2-(2-{2-[2-(4-Methoxy-[1,2,5]thiadiazol-3-yloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-[1,2,5]thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydro-pyridine hydrochloride Show/Hide	C19H30ClN5O6S2	1
1	Ki = 25.12 nM Bioactivity Info	TI LI LO TS
CP0847850 Compound Info	di(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether Show/Hide	C15H21N5O4S2	1
1	Ki = 50.12 nM Bioactivity Info	TI LI LO TS
CP0846924 Compound Info	5-{4-[12-(4-Methoxy-[1,2,5]thiadiazol-3-yloxy)-dodecyloxy]-[1,2,5]thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydro-pyridine Show/Hide	C23H37N5O3S2	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0853783 Compound Info	12-[4-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-[1,2,5]thiadiazol-3-yloxy]-dodecan-1-ol hydrochloride Show/Hide	C20H36ClN3O2S	1
1	Ki = 79.43 nM Bioactivity Info	TI LI LO TS
CP0849748 Compound Info	Acetic acid 12-[4-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-[1,2,5]thiadiazol-3-yloxy]-dodecyl ester hydrochloride Show/Hide	C22H38ClN3O3S	1
1	Ki = 125.89 nM Bioactivity Info	TI LI LO TS
CP0847851 Compound Info	tri(propylene glycol)(3-methoxy-1,2,4-thiadiazol-5-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether Show/Hide	C19H25N5O5S2	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0847853 Compound Info	tri(propylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether Show/Hide	C19H25N5O5S2	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0847854 Compound Info	tri(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether Show/Hide	C17H25N5O5S2	1
1	Ki = 251.19 nM Bioactivity Info	TI LI LO TS
CP0781215 Compound Info	tetra(ethylene glycol)(3-methoxy-1,2,4-thiadiazol-5-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether Show/Hide	C19H29N5O6S2	1
1	Ki = 316.23 nM Bioactivity Info	TI LI LO TS
CP0847381 Compound Info	2-(2-(2-(2-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-yloxy)ethoxy)ethoxy)ethoxy)ethanol Show/Hide	C16H27N3O5S	1
1	Ki = 316.23 nM Bioactivity Info	TI LI LO TS
CP0739672 Compound Info	penta(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether Show/Hide	C21H33N5O7S2	1
1	Ki = 1584.89 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000051 , BHK-21

Cell Line Info

Cell Line ID: CL000108 , CCRF-CEM

Cell Line Info

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000845 , CHO-K9

Cell Line Info

Cell Line ID: CL000386 , Flp-In-CHO

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000035 , NIH 3T3

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000289 , SK-N-SH

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0037621 Compound Info	(oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyrrolidin-2-one Show/Hide	C12H18N2O	1
1	EC50 = 210 nM
CP0018455 Compound Info	1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid methyl ester;hydrobromide Show/Hide	C8H13NO2	3
1	EC50 = 340 nM
2	IC50 = 11000 nM
3	Ki = 43000 nM
CP0635477 Compound Info	(2-Carbamoyloxy-ethyl)-trimethyl-ammonium chloride Show/Hide	C6H15ClN2O2	3
1	EC50 = 1800 nM
2	IC50 = 9100 nM
3	Ki = 20000 nM
CP0113928 Compound Info	1-(4-bromobenzyl)indoline-2,3-dione Show/Hide	C15H10BrNO2	1
1	EC50 = 6400 nM
CP0059332 Compound Info	1-(4-methoxybenzyl)-5-(trifluoromethoxy)indoline-2,3-dione Show/Hide	C17H12F3NO4	1
1	EC50 > 30000 nM
CP0673968 Compound Info	SID50106181 Show/Hide	C21H26INO2	8
1	IC50 = 0.43 nM
2	IC50 = 0.56 nM
3	IC50 = 0.59 nM
4	IC50 = 1.9 nM
5	IC50 = 2.6 nM
6	Ki = 0.4 nM
7	Ki = 0.42 nM
8	Ki = 0.4467 nM
CP0088670 Compound Info	Batefenterol Show/Hide	C40H42ClN5O7	1
1	IC50 = 1.585 nM
CP0734482 Compound Info	US9315463, 12 Show/Hide	C39H43ClN4O9S2	1
1	IC50 = 1.585 nM
CP0002227 Compound Info	SOLIFENACIN Show/Hide	C23H26N2O2	1
1	IC50 = 24 nM
CP0049755 Compound Info	(R)-1-Aza-bicyclo[2.2.2]oct-3-yl-[(Z)-methoxyimino]-acetonitrile Show/Hide	C10H15N3O	1
1	IC50 = 60 nM
CP0317131 Compound Info	(9bS)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydroimidazo[2,1-a]isoindol-5-one Show/Hide	C23H15ClF2N2O2	1
1	IC50 > 30000 nM
CP0739672 Compound Info	penta(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether Show/Hide	C21H33N5O7S2	1
1	Kd = 63.1 nM
CP0179471 Compound Info	3-methoxy-4-[2-[2-[2-[2-[[4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazol-3-yl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-1,2,5-thiadiazole Show/Hide	C19H29N5O6S2	1
1	Kd = 158.49 nM
CP0781215 Compound Info	tetra(ethylene glycol)(3-methoxy-1,2,4-thiadiazol-5-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether Show/Hide	C19H29N5O6S2	1
1	Kd = 158.49 nM
CP0696953 Compound Info	Aclidinium bromide Show/Hide	C26H30BrNO4S2	1
1	Ki = 0.07 nM
CP0705209 Compound Info	(3R)-3-{[(2S)-2-Cyclopentyl-2-hydroxy-2-(2-thienyl)acetyl]-oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide Show/Hide	C27H36BrNO4S	1
1	Ki = 0.07 nM
CP0666488 Compound Info	(3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide Show/Hide	C25H28BrNO3S2	1
1	Ki = 0.08 nM
CP0090719 Compound Info	US8551978, I-60 Show/Hide	C50H54N6O7	1
1	Ki = 0.1 nM
CP0090722 Compound Info	US8551978, I-65 Show/Hide	C50H54N6O7	1
1	Ki = 0.1 nM
CP0090723 Compound Info	US8551978, I-88 Show/Hide	C52H58N6O7	1
1	Ki = 0.1 nM
CP0090724 Compound Info	US8551978, I-89 Show/Hide	C52H58N6O7	1
1	Ki = 0.1 nM
CP0127264 Compound Info	US8551978, I-94 Show/Hide	C52H58N6O8	1
1	Ki = 0.1 nM
CP0172954 Compound Info	US8551978, I-32 Show/Hide	C48H50N6O7	1
1	Ki = 0.1 nM
CP0175289 Compound Info	US8551978, I-57 Show/Hide	C51H56N6O7	1
1	Ki = 0.1 nM
CP0188924 Compound Info	US8551978, I-68 Show/Hide	C51H56N6O7	1
1	Ki = 0.1 nM
CP0188926 Compound Info	US8551978, I-84 Show/Hide	C51H55FN6O7	1
1	Ki = 0.1 nM
CP0211764 Compound Info	US8551978, I-16 Show/Hide	C46H54N6O8	1
1	Ki = 0.1 nM
CP0223279 Compound Info	US8551978, I-2 Show/Hide	C45H52N6O7	1
1	Ki = 0.1 nM
CP0224162 Compound Info	US8551978, I-96 Show/Hide	C50H54N6O7	1
1	Ki = 0.1 nM
CP0226204 Compound Info	US8551978, I-81 Show/Hide	C52H58N6O8	1
1	Ki = 0.1 nM
CP0227538 Compound Info	US8551978, I-79 Show/Hide	C51H56N6O7	1
1	Ki = 0.1 nM
CP0250247 Compound Info	US8551978, I-3 Show/Hide	C45H52N6O8	1
1	Ki = 0.1 nM
CP0250252 Compound Info	US8551978, I-77 Show/Hide	C51H56N6O7	1
1	Ki = 0.1 nM
CP0293285 Compound Info	US8551978, I-5 Show/Hide	C46H54N6O7	1
1	Ki = 0.1 nM
CP0293286 Compound Info	US8551978, I-10 Show/Hide	C46H54N6O7	1
1	Ki = 0.1 nM
CP0315619 Compound Info	US8551978, I-6 Show/Hide	C45H51ClN6O8	1
1	Ki = 0.1 nM
CP0315620 Compound Info	US8551978, I-24 Show/Hide	C48H58N6O7	1
1	Ki = 0.1 nM
CP0315621 Compound Info	US8551978, I-82 Show/Hide	C52H58N6O8	1
1	Ki = 0.1 nM
CP0321872 Compound Info	US8551978, I-19 Show/Hide	C46H53ClN6O8	1
1	Ki = 0.1 nM
CP0321873 Compound Info	US8551978, I-23 Show/Hide	C48H58N6O7	1
1	Ki = 0.1 nM
CP0321875 Compound Info	US8551978, I-59 Show/Hide	C48H50N6O7	1
1	Ki = 0.1 nM
CP0383578 Compound Info	US8551978, I-87 Show/Hide	C52H58N6O7	1
1	Ki = 0.1 nM
CP0384079 Compound Info	US8551978, I-71 Show/Hide	C52H58N6O7	1
1	Ki = 0.1 nM
CP0384093 Compound Info	US8551978, I-90 Show/Hide	C52H58N6O7	1
1	Ki = 0.1 nM
CP0387713 Compound Info	US8551978, I-12 Show/Hide	C47H56N6O7	1
1	Ki = 0.1 nM
CP0393354 Compound Info	US8551978, I-49 Show/Hide	C50H54N6O7	1
1	Ki = 0.1 nM
CP0394815 Compound Info	US8551978, I-11 Show/Hide	C47H56N6O7	1
1	Ki = 0.1 nM
CP0418272 Compound Info	US8551978, I-27 Show/Hide	C48H50N6O7	1
1	Ki = 0.1 nM
CP0418392 Compound Info	US8551978, I-46 Show/Hide	C50H54N6O7	1
1	Ki = 0.1 nM
CP0479070 Compound Info	US8551978, I-25 Show/Hide	C47H48N6O7	1
1	Ki = 0.1 nM
CP0480766 Compound Info	US8551978, I-40 Show/Hide	C49H52N6O7	1
1	Ki = 0.1 nM
CP0480783 Compound Info	US8551978, I-63 Show/Hide	C49H52N6O7	1
1	Ki = 0.1 nM
CP0484460 Compound Info	US8551978, I-53 Show/Hide	C50H54N6O7	1
1	Ki = 0.1 nM
CP0491886 Compound Info	US8551978, I-61 Show/Hide	C49H51ClN6O8	1
1	Ki = 0.1 nM
CP0516802 Compound Info	US8551978, I-21 Show/Hide	C46H54N6O7	1
1	Ki = 0.1 nM
CP0524444 Compound Info	US8551978, I-14 Show/Hide	C45H52N6O7	1
1	Ki = 0.1 nM
CP0529358 Compound Info	US8551978, I-17 Show/Hide	C46H54N6O8	1
1	Ki = 0.1 nM
CP0539113 Compound Info	US8551978, I-43 Show/Hide	C49H52N6O7	1
1	Ki = 0.1 nM
CP0539114 Compound Info	US8551978, 266 Show/Hide	C45H52N6O8	1
1	Ki = 0.1 nM
CP0540722 Compound Info	US8551978, I-69 Show/Hide	C51H56N6O7	1
1	Ki = 0.1 nM
CP0542047 Compound Info	US8551978, I-44 Show/Hide	C50H54N6O7	1
1	Ki = 0.1 nM
CP0549630 Compound Info	US8551978, I-20 Show/Hide	C46H54N6O7	1
1	Ki = 0.1 nM
CP0551307 Compound Info	US8551978, I-22 Show/Hide	C48H58N6O7	1
1	Ki = 0.1 nM
CP0551356 Compound Info	US8551978, I-62 Show/Hide	C49H52N6O7	1
1	Ki = 0.1 nM
CP0553835 Compound Info	US8551978, I-9 Show/Hide	C46H54N6O8	1
1	Ki = 0.1 nM
CP0553836 Compound Info	US8551978, I-29 Show/Hide	C48H50N6O8	1
1	Ki = 0.1 nM
CP0569070 Compound Info	US8551978, I-1 Show/Hide	C44H50N6O7	1
1	Ki = 0.1 nM
CP0036569 Compound Info	(R)-3-(3-methoxyquinuclidin-3-yl)-1,1-diphenylprop-2-yn-1-ol Show/Hide	C23H25NO2	1
1	Ki = 0.13 nM
CP0666404 Compound Info	Tiotropium bromide Show/Hide	C19H24BrNO5S2	1
1	Ki = 0.14 nM
CP0090718 Compound Info	US8551978, I-54 Show/Hide	C51H56N6O8	1
1	Ki = 0.2 nM
CP0172957 Compound Info	US8551978, I-51 Show/Hide	C50H54N6O7	1
1	Ki = 0.2 nM
CP0175286 Compound Info	US8551978, I-39 Show/Hide	C49H52N6O7	1
1	Ki = 0.2 nM
CP0175287 Compound Info	US8551978, I-52 Show/Hide	C50H54N6O7	1
1	Ki = 0.2 nM
CP0175290 Compound Info	US8551978, I-86 Show/Hide	C52H58N6O7	1
1	Ki = 0.2 nM
CP0227528 Compound Info	US8551978, I-37 Show/Hide	C50H54N6O7	1
1	Ki = 0.2 nM
CP0231278 Compound Info	US8551978, I-92 Show/Hide	C52H58N6O7	1
1	Ki = 0.2 nM
CP0231309 Compound Info	US8551978, I-45 Show/Hide	C51H56N6O7	1
1	Ki = 0.2 nM
CP0250248 Compound Info	US8551978, I-28 Show/Hide	C49H52N6O7	1
1	Ki = 0.2 nM
CP0250249 Compound Info	US8551978, I-36 Show/Hide	C49H52N6O7	1
1	Ki = 0.2 nM
CP0250250 Compound Info	US8551978, I-55 Show/Hide	C51H56N6O7	1
1	Ki = 0.2 nM
CP0250251 Compound Info	US8551978, I-73 Show/Hide	C51H55FN6O7	1
1	Ki = 0.2 nM
CP0293287 Compound Info	US8551978, I-33 Show/Hide	C49H52N6O7	1
1	Ki = 0.2 nM
CP0293288 Compound Info	US8551978, I-38 Show/Hide	C49H52N6O7	1
1	Ki = 0.2 nM
CP0325962 Compound Info	US8551978, I-26 Show/Hide	C48H50N6O7	1
1	Ki = 0.2 nM
CP0384061 Compound Info	US8551978, I-85 Show/Hide	C52H58N6O7	1
1	Ki = 0.2 nM
CP0418391 Compound Info	US8551978, I-47 Show/Hide	C51H56N6O7	1
1	Ki = 0.2 nM
CP0442142 Compound Info	US8551978, I-56 Show/Hide	C51H56N6O7	1
1	Ki = 0.2 nM
CP0443669 Compound Info	US8551978, I-58 Show/Hide	C51H56N6O7	1
1	Ki = 0.2 nM
CP0451573 Compound Info	US8551978, I-80 Show/Hide	C51H56N6O7	1
1	Ki = 0.2 nM
CP0457084 Compound Info	US8551978, I-95 Show/Hide	C51H55FN6O7	1
1	Ki = 0.2 nM
CP0484461 Compound Info	US8551978, I-42 Show/Hide	C49H52N6O7	1
1	Ki = 0.2 nM
CP0490783 Compound Info	US8551978, I-30 Show/Hide	C49H52N6O7	1
1	Ki = 0.2 nM
CP0531315 Compound Info	US8551978, I-75 Show/Hide	C49H52N6O7	1
1	Ki = 0.2 nM
CP0536252 Compound Info	US8551978, I-31 Show/Hide	C48H49ClN6O8	1
1	Ki = 0.2 nM
CP0550490 Compound Info	US8551978, I-83 Show/Hide	C52H58N6O8	1
1	Ki = 0.2 nM
CP0550491 Compound Info	US8551978, I-91 Show/Hide	C52H58N6O7	1
1	Ki = 0.2 nM
CP0067391 Compound Info	(2R)-1-((2S,4R)-4-hydroxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidine-2-yl)carbonyl-N-(4-piperidinylmethyl)pyrrolidine-2-carboxamide Show/Hide	C37H41F3N4O4	1
1	Ki = 0.3 nM
CP0127263 Compound Info	US8551978, I-74 Show/Hide	C49H52N6O7	1
1	Ki = 0.3 nM
CP0211696 Compound Info	US8551978, I-76 Show/Hide	C50H54N6O7	1
1	Ki = 0.3 nM
CP0211766 Compound Info	US8551978, I-48 Show/Hide	C50H54N6O7	1
1	Ki = 0.3 nM
CP0226203 Compound Info	US8551978, I-78 Show/Hide	C51H56N6O7	1
1	Ki = 0.3 nM
CP0443670 Compound Info	US8551978, I-70 Show/Hide	C52H58N6O7	1
1	Ki = 0.3 nM
CP0539111 Compound Info	US8551978, I-41 Show/Hide	C50H54N6O7	1
1	Ki = 0.3 nM
CP0551906 Compound Info	US8551978, I-64 Show/Hide	C50H54N6O7	1
1	Ki = 0.3 nM
CP0224386 Compound Info	5-((R)-2-(4-(4-(3-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)butoxy)phenethylamino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one Show/Hide	C44H55N3O5	1
1	Ki = 0.31 nM
CP0227532 Compound Info	US8551978, I-50 Show/Hide	C50H54N6O7	1
1	Ki = 0.4 nM
CP0529360 Compound Info	US8551978, I-72 Show/Hide	C52H58N6O8	1
1	Ki = 0.4 nM
CP0080609 Compound Info	1-Cyclohexyl-4-{1-[4-(4-methoxy-benzenesulfonyl)-phenyl]-vinyl}-piperidine Show/Hide	C26H33NO3S	1
1	Ki = 0.48 nM
CP0315444 Compound Info	US8551978, I-93 Show/Hide	C52H58N6O7	1
1	Ki = 0.8 nM
CP0116358 Compound Info	(R)-1-(9-(2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl biphenyl-2-ylcarbamate Show/Hide	C38H48N4O5	1
1	Ki = 0.82 nM
CP0070586 Compound Info	Ipratropium Bromide Show/Hide	C20H30BrNO3	1
1	Ki = 0.83 nM
CP0010653 Compound Info	2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-2,2-diphenyl-acetamide (Darifenacin) Show/Hide	C28H30N2O2	1
1	Ki = 1.3 nM
CP0062485 Compound Info	4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester Show/Hide	C22H31NO3	1
1	Ki = 1.3 nM
CP0159311 Compound Info	6-(azepan-1-yl)-N,2-dicyclopropyl-5-methylpyrimidin-4-amine Show/Hide	C17H26N4	1
1	Ki = 3.162 nM
CP0007317 Compound Info	(+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol Show/Hide	C22H31NO	2
1	Ki = 3.2 nM
2	Ki = 3.6 nM
CP0172665 Compound Info	(S)-1-cyclohexyl-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenylprop-2-yn-1-ol Show/Hide	C23H31NO2	1
1	Ki = 3.2 nM
CP0178512 Compound Info	(R)-2-Cyclopentyl-2-hydroxy-N-[1-(4-methyl-pent-3-enyl)-piperidin-4-yl]-2-phenyl-acetamide Show/Hide	C24H36N2O2	1
1	Ki = 4.2 nM
CP0164673 Compound Info	2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester Show/Hide	C21H27NO2	1
1	Ki = 7.7 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	1
1	Ki = 100 nM
CP0067390 Compound Info	ethyl 6-butyl-17-methoxy-12-oxa-1,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),5,9,14(19),15,17-heptaene-5-carboxylate Show/Hide	C26H30N2O4	1
1	Ki = 151 nM
CP0056034 Compound Info	11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one Show/Hide	C19H21N5O2	1
1	Ki = 158 nM
CP0026924 Compound Info	N-[1-[3-(3-oxo-1,4-benzoxazin-4-yl)propyl]piperidin-4-yl]-2-phenylacetamide Show/Hide	C24H29N3O3	1
1	Ki >= 1000 nM
CP0029624 Compound Info	4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Show/Hide	C20H31NO	1
1	Ki >= 1000 nM

Clinical Information about the Protein

Target 1 ( Muscarinic acetylcholine receptor M3 (CHRM3) )

Target Type	Successful Target
Disease	8 Target-related Diseases				8
1	Glaucoma/ocular hypertension [ICD-11: 9C61]
2	Overactive bladder [ICD-11: GC50.0]
3	Obstructive lung disease [ICD-11: CA22.Z]
4	Chronic obstructive pulmonary disease [ICD-11: CA22]
5	bronchial hyperreactivity [ICD-11: CB40]
6	Peptic ulcer [ICD-11: DA61]
7	Spasm [ICD-11: MB47.3]
8	Alzheimer disease [ICD-11: 8A20]
Approved Drug(s)	9 Approved Drugs				9
1	ACECLIDINE	Drug Info	Approved	Glaucoma/ocular hypertension
2	Darifenacin	Drug Info	Approved	Overactive bladder
3	Ipratropium	Drug Info	Approved	Obstructive lung disease
4	LAS-34273	Drug Info	Approved	Chronic obstructive pulmonary disease
5	Methacholine Chloride	Drug Info	Approved	bronchial hyperreactivity
6	Methylscopolamine	Drug Info	Approved	Peptic ulcer
7	Solifenacin	Drug Info	Approved	Overactive bladder
8	Succinylcholine	Drug Info	Approved	Spasm
9	Tolterodine	Drug Info	Approved	Overactive bladder
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	Tarafenacin	Drug Info	Phase 2	Overactive bladder
Discontinued Drug(s)	1 Discontinued Drug				1
1	Alvameline	Drug Info	Terminated	Alzheimer disease

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT01713	Muscarinic acetylcholine receptor M3	Rattus norvegicus, Rat	Protein Info
PT06153	Muscarinic acetylcholine receptor M3	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han