General Information of the Protein
Protein ID
PT06153
Protein Name
Muscarinic acetylcholine receptor M3
Secondarily
Protein Name
Mm3 mAChR
Gene Name
CHRM3
Secondarily
Gene Name
Chrm-3
Sequence
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Acetylcholine receptor
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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Uniprot ID
Primary ID:
Q9ERZ3

Secondarily ID:
Q64055
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Ensembl ID
ENSG00000133019
Subcellular Location
Cell membrane
Postsynaptic cell membrane
Basolateral cell membrane
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000398 , A-9
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0845687
 Compound Info 
5-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1,4,5,6-tetrahydro-pyrimidine TFA
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C9H11F3N4O3
  1
1
EC50 = 1100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0374204
 Compound Info 
1-Methyl-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-1,2,3,6-tetrahydro-pyridine
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C9H13N3O
  1
1
EC50 = 2800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0847223
 Compound Info 
5-(3-Methylsulfanylmethyl-[1,2,4]oxadiazol-5-yl)-1,4,5,6-tetrahydro-pyrimidine TFA
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C10H13F3N4O3S
  1
1
EC50 = 5800 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0635477
 Compound Info 
(2-Carbamoyloxy-ethyl)-trimethyl-ammonium chloride
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C6H15ClN2O2
  1
1
EC50 = 9900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0210785
 Compound Info 
Aceclidine
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C9H15NO2
  1
1
EC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0847680
 Compound Info 
5-(3-Ethyl-[1,2,4]oxadiazol-5-yl)-1,4,5,6-tetrahydro-pyrimidine TFA
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C10H13F3N4O3
  1
1
EC50 = 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0371787
 Compound Info 
5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid
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C14H23N3OS
  1
1
EC50 = 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0940888
 Compound Info 
5-(3-Methoxymethyl-[1,2,4]oxadiazol-5-yl)-1,4,5,6-tetrahydro-pyrimidine TFA
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C10H13F3N4O4
  1
1
EC50 = 11000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0018455
 Compound Info 
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid methyl ester;hydrobromide
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C8H13NO2
  1
1
EC50 = 12000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0849885
 Compound Info 
6-Amino-2,3,4,5-tetrahydro-pyridine-3-carboxylic acid prop-2-ynyl ester hydrochloride
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C9H13ClN2O2
  1
1
EC50 = 12000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0879042
 Compound Info 
6-Amino-2,3,4,5-tetrahydro-pyridine-3-carboxylic acid methyl ester hydrochloride
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C7H13ClN2O2
  1
1
EC50 = 14000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0859779
 Compound Info 
1,4,5,6-Tetrahydro-pyrimidine-5-carboxylic acid ethyl ester hydrochloride
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C7H13ClN2O2
  1
1
EC50 = 17000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0875146
 Compound Info 
1,4,5,6-Tetrahydro-pyrimidine-5-carboxylic acid prop-2-ynyl ester hydrochloride
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C8H11ClN2O2
  1
1
EC50 = 18000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0856374
 Compound Info 
1,4,5,6-Tetrahydro-pyrimidine-5-carboxylic acid methyl ester hydrochloride
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C6H11ClN2O2
  1
1
EC50 = 50000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01266 Muscarinic acetylcholine receptor M3 Homo sapiens, Human
 Protein Info 
PT01713 Muscarinic acetylcholine receptor M3 Rattus norvegicus, Rat
 Protein Info