General Information of the Protein
Protein ID
PT01713
Protein Name
Muscarinic acetylcholine receptor M3
Gene Name
CHRM3
Secondarily
Gene Name
Chrm-3
Sequence
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Acetylcholine receptor
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
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Uniprot ID
Primary ID:
P08483

Secondarily ID:
Q9QWK9
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Ensembl ID
ENSG00000133019
Subcellular Location
Cell membrane
Postsynaptic cell membrane
Basolateral cell membrane
Endoplasmic reticulum membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000047 , 108CC15
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0279976
 Compound Info 
N-methyl-N-(5-pyrrolidin-1-ylpent-3-yn-2-yl)acetamide
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C12H20N2O
  1
1
Ki = 580 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0848705
 Compound Info 
8-Amino-octanoic acid methyl-(4-pyrrolidin-1-yl-but-2-ynyl)-amide: (2 TFA)
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C21H33F6N3O5
  1
1
Ki = 700 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0885425
 Compound Info 
{7-[Methyl-(4-pyrrolidin-1-yl-but-2-ynyl)-carbamoyl]-heptyl}-carbamic acid tert-butyl ester: (0.25 oxalate)
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C24H41N3O7
  1
1
Ki = 1900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0848884
 Compound Info 
7-Amino-heptanoic acid methyl-(4-pyrrolidin-1-yl-but-2-ynyl)-amide: (2 TFA)
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C20H31F6N3O5
  1
1
Ki = 3100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0894016
 Compound Info 
{6-[Methyl-(4-pyrrolidin-1-yl-but-2-ynyl)-carbamoyl]-hexyl}-carbamic acid tert-butyl ester: (0.5 oxalate)
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C23H39N3O7
  1
1
Ki = 3200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0399506
 Compound Info 
N-methyl-N-(4-pyrrolidin-1-ylbut-2-ynyl)acetamide
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C11H18N2O
  1
1
Ki = 4500 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000398 , A-9
 Cell Line Info 
Cell Line ID: CL000011 , CHO
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0056034
 Compound Info 
11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
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C19H21N5O2
  1
1 Ki = 173.78 nM
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT01266 Muscarinic acetylcholine receptor M3 Homo sapiens, Human
 Protein Info 
PT06153 Muscarinic acetylcholine receptor M3 Mus musculus, Mouse
 Protein Info