General Information of the Compound
Compound ID
CP0845687
Compound Name
5-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1,4,5,6-tetrahydro-pyrimidine TFA
    Show/Hide
Structure
Formula
C9H11F3N4O3
Molecular Weight
280.206
Canonical SMILES
Cc1noc(C2CN=CNC2)n1.O=C(O)C(F)(F)F
    Show/Hide
InChI
InChI=1S/C7H10N4O.C2HF3O2/c1-5-10-7(12-11-5)6-2-8-4-9-3-6;3-2(4,5)1(6)7/h4,6H,2-3H2,1H3,(H,8,9);(H,6,7)
    Show/Hide
InChIKey
VNNPKITYMMVTIG-UHFFFAOYSA-N
Physicochemical Property
logP
0.72642
Rotatable Bonds
1
Heavy Atom Count
19
Polar Areas
100.61
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
19

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 9838580
SID: 14799613
ChEMBL ID
CHEMBL277014
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03415, Muscarinic acetylcholine receptor M1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000398 A-9 Mus musculus (Mouse)  4
1
EC50 = 5400 nM
   TI
   LI
   LO
   TS
2
Ki = 2.31 nM
   TI
   LI
   LO
   TS
3
Ki = 2.5 nM
   TI
   LI
   LO
   TS
4
Ki = 21.1 nM
   TI
   LI
   LO
   TS
Protein ID: PT06153, Muscarinic acetylcholine receptor M3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000398 A-9 Mus musculus (Mouse)  1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS