Protein Information

General Information of the Protein

Protein ID	PT01358
Protein Name	D(1A) dopamine receptor
Secondarily Protein Name	Dopamine D1 receptor
Gene Name	DRD1
Secondarily Gene Name	D1AR
Sequence	MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT Show/Hide
Organism	Bos taurus, Bovine
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Dopamine receptor
Function	Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Show/Hide
Uniprot ID	Primary ID: Q95136 Secondarily ID: A4IFG9 Q8WND7 Show/Hide
Subcellular Location	Cell membrane Endoplasmic reticulum membrane Cell projection Cilium membrane Cell projection Dendrite Cell projection Dendritic spine

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	1
1	Ki = 420 nM Bioactivity Info	TI LI LO TS
CP0178941 Compound Info	3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-7-ethynyl-pyrazolo[1,5-a]pyridine Show/Hide	C20H19ClN4	1
1	Ki = 810 nM Bioactivity Info	TI LI LO TS
CP0381009 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-phenyl-pyrazolo[1,5-a]pyridine Show/Hide	C24H23ClN4	1
1	Ki = 930 nM Bioactivity Info	TI LI LO TS
CP0442588 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-(4-fluoro-phenyl)-2-methyl-pyrazolo[1,5-a]pyridine Show/Hide	C25H24ClFN4	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0480184 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridine-7-carbaldehyde Show/Hide	C19H19ClN4O	1
1	Ki = 1200 nM Bioactivity Info	TI LI LO TS
CP0104629 Compound Info	(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyrazolo[1,5-a]pyridin-6-yl)methanol Show/Hide	C19H21ClN4O	1
1	Ki = 1400 nM Bioactivity Info	TI LI LO TS
CP0403324 Compound Info	7-(4-Benzyl-piperazin-1-yl)-3-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridine Show/Hide	C29H33ClN6	1
1	Ki = 1500 nM Bioactivity Info	TI LI LO TS
CP0453469 Compound Info	7-(4-Benzyl-piperazin-1-yl)-3-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-2-methyl-pyrazolo[1,5-a]pyridine Show/Hide	C30H35ClN6	1
1	Ki = 1500 nM Bioactivity Info	TI LI LO TS
CP0324173 Compound Info	3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-7-methylH-pyrazolo[1,5-a]pyridine Show/Hide	C19H21ClN4	1
1	Ki = 2200 nM Bioactivity Info	TI LI LO TS
CP0405288 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridine-7-carbonitrile Show/Hide	C19H18ClN5	1
1	Ki = 2500 nM Bioactivity Info	TI LI LO TS
CP0430726 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-2-methyl-7-phenyl-pyrazolo[1,5-a]pyridine Show/Hide	C25H25ClN4	1
1	Ki = 3300 nM Bioactivity Info	TI LI LO TS
CP0405399 Compound Info	[3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridin-4-yl]methanol Show/Hide	C19H21ClN4O	1
1	Ki = 4800 nM Bioactivity Info	TI LI LO TS
CP0420836 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-4-methyl-pyrazolo[1,5-a]pyridine Show/Hide	C19H21ClN4	1
1	Ki = 7000 nM Bioactivity Info	TI LI LO TS
CP0439308 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine Show/Hide	C24H22ClFN4	1
1	Ki = 7000 nM Bioactivity Info	TI LI LO TS
CP0381010 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-trimethylsilanyl-pyrazolo[1,5-a]pyridine Show/Hide	C21H27ClN4Si	1
1	Ki = 7100 nM Bioactivity Info	TI LI LO TS
CP0046420 Compound Info	CAS_3853 Show/Hide	C18H19ClN4	1
1	Ki = 9900 nM Bioactivity Info	TI LI LO TS
CP0449675 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-2-methyl-pyrazolo[1,5-a]pyridine-7-carbonitrile Show/Hide	C20H20ClN5	1
1	Ki = 11000 nM Bioactivity Info	TI LI LO TS
CP0448005 Compound Info	((R)-3-Methyl-5,6,7,8-tetrahydro-indolizin-7-yl)-dipropyl-amine Show/Hide	C15H26N2	1
1	Ki = 12000 nM Bioactivity Info	TI LI LO TS
CP0084794 Compound Info	3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyrazolo[1,5-a]pyridine Show/Hide	C18H19ClN4	1
1	Ki = 12000 nM Bioactivity Info	TI LI LO TS
CP0399841 Compound Info	((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizin-3-yl)-methanol Show/Hide	C15H26N2O	1
1	Ki = 13000 nM Bioactivity Info	TI LI LO TS
CP0380592 Compound Info	3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-7-ethynyl-2-methyl-pyrazolo[1,5-a]pyridine Show/Hide	C21H21ClN4	1
1	Ki = 15000 nM Bioactivity Info	TI LI LO TS
CP0290176 Compound Info	(S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-3-carbaldehyde Show/Hide	C15H24N2O	1
1	Ki = 26000 nM Bioactivity Info	TI LI LO TS
CP0430147 Compound Info	((S)-3-Methyl-5,6,7,8-tetrahydro-indolizin-7-yl)-dipropyl-amine Show/Hide	C15H26N2	1
1	Ki = 29000 nM Bioactivity Info	TI LI LO TS
CP0415031 Compound Info	((S)-2-Methyl-5,6,7,8-tetrahydro-indolizin-7-yl)-dipropyl-amine Show/Hide	C15H26N2	1
1	Ki = 44000 nM Bioactivity Info	TI LI LO TS
CP0480560 Compound Info	(R)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-3-carbaldehyde Show/Hide	C15H24N2O	1
1	Ki = 47000 nM Bioactivity Info	TI LI LO TS
CP0495918 Compound Info	((S)-1-Methyl-5,6,7,8-tetrahydro-indolizin-7-yl)-dipropyl-amine Show/Hide	C15H26N2	1
1	Ki = 68000 nM Bioactivity Info	TI LI LO TS
CP0409472 Compound Info	((R)-1-Methyl-5,6,7,8-tetrahydro-indolizin-7-yl)-dipropyl-amine Show/Hide	C15H26N2	1
1	Ki = 71000 nM Bioactivity Info	TI LI LO TS
CP0404789 Compound Info	(R)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-1-carbaldehyde Show/Hide	C15H24N2O	1
1	Ki = 80000 nM Bioactivity Info	TI LI LO TS
CP0430146 Compound Info	((R)-2-Methyl-5,6,7,8-tetrahydro-indolizin-7-yl)-dipropyl-amine Show/Hide	C15H26N2	1
1	Ki = 83000 nM Bioactivity Info	TI LI LO TS
CP0373655 Compound Info	((R)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizin-3-yl)-methanol Show/Hide	C15H26N2O	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0376569 Compound Info	((R)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizin-2-yl)-methanol Show/Hide	C15H26N2O	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0391281 Compound Info	(7R)-N,N-dipropyl-5,6,7,8-tetrahydroindolizin-7-amine Show/Hide	C14H24N2	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0391290 Compound Info	((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizin-1-yl)-methanol Show/Hide	C15H26N2O	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0391307 Compound Info	((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizin-2-yl)-methanol Show/Hide	C15H26N2O	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0406351 Compound Info	(S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-1-carbaldehyde Show/Hide	C15H24N2O	1
1	Ki > 100000 nM Bioactivity Info	TI LI LO TS
CP0505105 Compound Info	((R)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizin-1-yl)-methanol Show/Hide	C15H26N2O	1
1	Ki = 100000 nM Bioactivity Info	TI LI LO TS

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	1
1	Ki = 420 nM
CP0046420 Compound Info	CAS_3853 Show/Hide	C18H19ClN4	1
1	Ki = 9900 nM
CP0084794 Compound Info	3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyrazolo[1,5-a]pyridine Show/Hide	C18H19ClN4	1
1	Ki = 12000 nM
CP0290176 Compound Info	(S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-3-carbaldehyde Show/Hide	C15H24N2O	1
1	Ki > 20000 nM

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT03177	D(1A) dopamine receptor	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han