Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
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 PubChem ID
CID: 135398737
SID: 14826474
Canonical SMILES
CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
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Compound Formula C18H19ClN4
Compound Structure
Protein Name
 Protein Info 
D(2) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P61169
Gene Name
DRD2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
Ki = 190 nM
   TI
   LI
   LO
   TS
2
Ki = 260 nM
   TI
   LI
   LO
   TS
CL000053 COS-7
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  2
1
Ki = 63.1 nM
   TI
   LI
   LO
   TS
2
Ki = 64.2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 132 nM
2 IC50 = 290 nM
3 IC50 = 330 nM
4 IC50 = 410 nM
5 IC50 = 440 nM
6 IC50 = 830 nM
7 IC50 = 2108 nM
8 Ki = 34 nM
9 Ki = 45.71 nM
10 Ki = 53.6 nM
11 Ki = 82 nM
12 Ki = 210 nM
13 Ki = 250 nM
14 Ki = 251.19 nM
15 Ki = 263.03 nM
16 Ki = 319 nM