Protein Information

General Information of the Protein

Protein ID	PT00957
Protein Name	D(2) dopamine receptor
Secondarily Protein Name	Dopamine D2 receptor
Gene Name	DRD2
Sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Dopamine receptor
Function	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:1321233). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). Show/Hide
Uniprot ID	Primary ID: P61169 Secondarily ID: P13953 Show/Hide
Ensembl ID	ENSG00000149295
Subcellular Location	Cell membrane Golgi apparatus membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000011 , CHO

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	2
1	IC50 = 4.8 nM Bioactivity Info	TI LI LO TS
2	Ki = 1.1 nM Bioactivity Info	TI LI LO TS
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	1
1	IC50 = 5.2 nM Bioactivity Info	TI LI LO TS
CP0052226 Compound Info	1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-piperazine Show/Hide	C25H34N2O2	1
1	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0056556 Compound Info	1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-4-phenyl-piperazine Show/Hide	C24H32N2O	1
1	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0038828 Compound Info	1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-4-pyridin-2-yl-piperazine Show/Hide	C23H31N3O	1
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0339664 Compound Info	CHEBI:64217 Show/Hide	C21H26ClN3O2	1
1	Ki = 0.16 nM Bioactivity Info	TI LI LO TS
CP0439590 Compound Info	N-[(3S)-1-(9-bicyclo[3.3.1]nonanyl)pyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide Show/Hide	C22H32ClN3O2	1
1	Ki = 0.81 nM Bioactivity Info	TI LI LO TS
CP0430313 Compound Info	4-Amino-N-((S)-1-benzyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-benzamide Show/Hide	C19H22ClN3O2	1
1	Ki = 0.98 nM Bioactivity Info	TI LI LO TS
CP0418846 Compound Info	4-Amino-N-((R)-1-benzyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-benzamide Show/Hide	C19H22ClN3O2	1
1	Ki = 1.2 nM Bioactivity Info	TI LI LO TS
CP0033479 Compound Info	(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Show/Hide	C17H19ClN2S	1
1	Ki = 3 nM Bioactivity Info	TI LI LO TS
CP0192898 Compound Info	(4-Methoxy-indan-2-yl)-dipropyl-amine Show/Hide	C16H25NO	1
1	Ki = 4.2 nM Bioactivity Info	TI LI LO TS
CP0653714 Compound Info	SID50106387 Show/Hide	C8H12ClNO2	1
1	Ki = 4.7 nM Bioactivity Info	TI LI LO TS
CP0231107 Compound Info	(R)-2-Dipropylamino-indan-4-ol Show/Hide	C15H23NO	1
1	Ki = 5.2 nM Bioactivity Info	TI LI LO TS
CP0467378 Compound Info	N-(2-phenylethyl)-N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C23H28N2	1
1	Ki = 5.5 nM Bioactivity Info	TI LI LO TS
CP0378469 Compound Info	(8R)-N-(2-methylpropyl)-N-propyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C19H28N2	1
1	Ki = 5.7 nM Bioactivity Info	TI LI LO TS
CP0374866 Compound Info	(8R)-8-[3-phenylpropyl(propyl)amino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C25H30N2O	1
1	Ki = 5.8 nM Bioactivity Info	TI LI LO TS
CP0436775 Compound Info	N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-[(2,2,2-trifluoroacetyl)amino]benzamide Show/Hide	C21H21ClF3N3O3	1
1	Ki = 12 nM Bioactivity Info	TI LI LO TS
CP0378553 Compound Info	8-[(3-Phenyl-propyl)-propyl-amino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C25H30N2O	1
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0509509 Compound Info	(8R)-8-(dimethylamino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C15H18N2O	1
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0378377 Compound Info	8-{[3-(2-Methoxy-phenyl)-propyl]-propyl-amino}-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C26H32N2O2	1
1	Ki = 14 nM Bioactivity Info	TI LI LO TS
CP0276816 Compound Info	(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 17 nM Bioactivity Info	TI LI LO TS
CP0401203 Compound Info	5-Chloro-N-((S)-1-cycloheptyl-pyrrolidin-3-yl)-4-(cyclopropanecarbonyl-amino)-2-methoxy-benzamide Show/Hide	C23H32ClN3O3	1
1	Ki = 20 nM Bioactivity Info	TI LI LO TS
CP0424195 Compound Info	8-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C22H26N2OS	1
1	Ki = 25 nM Bioactivity Info	TI LI LO TS
CP0494189 Compound Info	4-Acryloylamino-N-((S)-1-benzyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-benzamide Show/Hide	C22H24ClN3O3	1
1	Ki = 27 nM Bioactivity Info	TI LI LO TS
CP0453746 Compound Info	(5,6-Dimethoxy-indan-2-yl)-phenethyl-propyl-amine Show/Hide	C22H29NO2	1
1	Ki = 27 nM Bioactivity Info	TI LI LO TS
CP0121646 Compound Info	4-[(10R,15S)-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5(16),6,8-trien-12-yl]-1-(4-fluorophenyl)butan-1-one Show/Hide	C24H27FN2O	1
1	Ki = 27 nM Bioactivity Info	TI LI LO TS
CP0411746 Compound Info	(10R,15S)-12-[3-(6-fluoro-2H-indazol-3-yl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-triene Show/Hide	C24H28FN5	1
1	Ki = 27 nM Bioactivity Info	TI LI LO TS
CP0416467 Compound Info	(8R)-8-[2-methylpropyl(propyl)amino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C20H28N2O	1
1	Ki = 28 nM Bioactivity Info	TI LI LO TS
CP0448144 Compound Info	8-{[3-(3-Chloro-phenoxy)-propyl]-propyl-amino}-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C25H29ClN2O2	1
1	Ki = 28 nM Bioactivity Info	TI LI LO TS
CP0115747 Compound Info	1-(4-fluorophenyl)-4-[(10R,15S)-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one Show/Hide	C23H26FN3O	1
1	Ki = 30 nM Bioactivity Info	TI LI LO TS
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	1
1	Ki = 31 nM Bioactivity Info	TI LI LO TS
CP0420757 Compound Info	5-Chloro-N-((S)-1-cyclohexylmethyl-pyrrolidin-3-yl)-4-(cyclopropanecarbonyl-amino)-2-methoxy-benzamide Show/Hide	C23H32ClN3O3	1
1	Ki = 32 nM Bioactivity Info	TI LI LO TS
CP0420813 Compound Info	N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(propanoylamino)benzamide Show/Hide	C22H26ClN3O3	1
1	Ki = 32 nM Bioactivity Info	TI LI LO TS
CP0115745 Compound Info	1-(4-fluorophenyl)-4-[(10R,15S)-4-methyl-1,4-diaza-12-azoniatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one;4-methylbenzenesulfonate Show/Hide	C31H36FN3O4S	1
1	Ki = 32 nM Bioactivity Info	TI LI LO TS
CP0052478 Compound Info	(+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 40 nM Bioactivity Info	TI LI LO TS
CP0132711 Compound Info	1-(4-fluorophenyl)-4-[(10R,15S)-4-oxa-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one Show/Hide	C23H25FN2O2	1
1	Ki = 41 nM Bioactivity Info	TI LI LO TS
CP0480060 Compound Info	4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-phenylbutan-1-one Show/Hide	C24H29N3O	1
1	Ki = 43 nM Bioactivity Info	TI LI LO TS
CP0480445 Compound Info	1-(4-fluorophenyl)-4-[(10R,15S)-7-methoxy-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one Show/Hide	C25H30FN3O2	1
1	Ki = 46 nM Bioactivity Info	TI LI LO TS
CP0480937 Compound Info	N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(2-methylpropanoylamino)benzamide Show/Hide	C23H28ClN3O3	1
1	Ki = 50 nM Bioactivity Info	TI LI LO TS
CP0416218 Compound Info	1-(4-fluorophenyl)-4-[(10R,15S)-4-thia-1,12-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one Show/Hide	C23H25FN2OS	1
1	Ki = 50 nM Bioactivity Info	TI LI LO TS
CP0411747 Compound Info	1-(4-fluorophenyl)-4-[(10R,15R)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one Show/Hide	C24H28FN3O	1
1	Ki = 52 nM Bioactivity Info	TI LI LO TS
CP0264289 Compound Info	2-Dipropylamino-indan-5-ol Show/Hide	C15H23NO	1
1	Ki = 53 nM Bioactivity Info	TI LI LO TS
CP0425117 Compound Info	8-(Allyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H24N2O	1
1	Ki = 59 nM Bioactivity Info	TI LI LO TS
CP0448143 Compound Info	8-Propylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C16H20N2O	1
1	Ki = 60 nM Bioactivity Info	TI LI LO TS
CP0432399 Compound Info	(5,6-Dimethoxy-indan-2-yl)-propyl-(2-thiophen-3-yl-ethyl)-amine Show/Hide	C20H27NO2S	1
1	Ki = 61 nM Bioactivity Info	TI LI LO TS
CP0380900 Compound Info	(8R)-8-[4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)butyl-propylamino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C27H37N3O3	1
1	Ki = 62 nM Bioactivity Info	TI LI LO TS
CP0392154 Compound Info	8-(Phenethyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C24H28N2O	1
1	Ki = 62 nM Bioactivity Info	TI LI LO TS
CP0502453 Compound Info	(5,6-Dimethoxy-indan-2-yl)-[2-(3,4-dimethoxy-phenyl)-ethyl]-propyl-amine Show/Hide	C24H33NO4	1
1	Ki = 66 nM Bioactivity Info	TI LI LO TS
CP0411744 Compound Info	4-[(10R,15S)-4-ethyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one Show/Hide	C25H30FN3O	1
1	Ki = 66 nM Bioactivity Info	TI LI LO TS
CP0414459 Compound Info	1-(4-fluorophenyl)-4-[(2S,8S)-14-oxa-1,5-diazatetracyclo[7.7.1.02,8.013,17]heptadeca-9(17),10,12-trien-5-yl]butan-1-one Show/Hide	C24H27FN2O2	1
1	Ki = 69 nM Bioactivity Info	TI LI LO TS
CP0483361 Compound Info	4-[(2R,7S)-4,8-diazatetracyclo[6.6.1.02,7.011,15]pentadeca-1(14),11(15),12-trien-4-yl]-1-(4-fluorophenyl)butan-1-one Show/Hide	C23H25FN2O	1
1	Ki = 71 nM Bioactivity Info	TI LI LO TS
CP0472164 Compound Info	5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-((S)-1-phenethyl-pyrrolidin-3-yl)-benzamide Show/Hide	C24H28ClN3O3	1
1	Ki = 82 nM Bioactivity Info	TI LI LO TS
CP0402468 Compound Info	5-Chloro-N-((S)-1-cyclohexyl-pyrrolidin-3-yl)-4-(cyclopropanecarbonyl-amino)-2-methoxy-benzamide Show/Hide	C22H30ClN3O3	1
1	Ki = 84 nM Bioactivity Info	TI LI LO TS
CP0480056 Compound Info	4-[(10R,15S)-4-benzyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-(4-fluorophenyl)butan-1-one Show/Hide	C30H32FN3O	1
1	Ki = 86 nM Bioactivity Info	TI LI LO TS
CP0401280 Compound Info	8-(Benzyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C23H26N2O	1
1	Ki = 90 nM Bioactivity Info	TI LI LO TS
CP0480065 Compound Info	1-(4-fluorophenyl)-4-[(10S,15R)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one Show/Hide	C24H28FN3O	1
1	Ki = 95 nM Bioactivity Info	TI LI LO TS
CP0440199 Compound Info	N-[2-(4-bromophenyl)ethyl]-5,6-dimethoxy-N-propyl-2,3-dihydro-1H-inden-2-amine Show/Hide	C22H28BrNO2	1
1	Ki = 97 nM Bioactivity Info	TI LI LO TS
CP0398726 Compound Info	1-(4-fluorophenyl)-4-[(10S,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one Show/Hide	C24H28FN3O	1
1	Ki = 97 nM Bioactivity Info	TI LI LO TS
CP0453461 Compound Info	N-[(3S)-1-(2-adamantyl)pyrrolidin-3-yl]-5-chloro-4-(cyclopropanecarbonylamino)-2-methoxybenzamide Show/Hide	C26H34ClN3O3	1
1	Ki = 110 nM Bioactivity Info	TI LI LO TS
CP0383519 Compound Info	4-{2-[(5,6-Dimethoxy-indan-2-yl)-propyl-amino]-ethyl}-benzamide Show/Hide	C23H30N2O3	1
1	Ki = 123 nM Bioactivity Info	TI LI LO TS
CP0464581 Compound Info	(5,6-Dimethoxy-indan-2-yl)-[2-(3-fluoro-phenyl)-ethyl]-propyl-amine Show/Hide	C22H28FNO2	1
1	Ki = 125 nM Bioactivity Info	TI LI LO TS
CP0376302 Compound Info	8-{[4-(4,4-Dimethyl-2,6-dioxo-piperidin-1-yl)-butyl]-propyl-amino}-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C27H37N3O3	1
1	Ki = 136 nM Bioactivity Info	TI LI LO TS
CP0455425 Compound Info	N-[(3S)-1-(9-bicyclo[3.3.1]nonanyl)pyrrolidin-3-yl]-5-chloro-4-(cyclopropanecarbonylamino)-2-methoxybenzamide Show/Hide	C25H34ClN3O3	1
1	Ki = 140 nM Bioactivity Info	TI LI LO TS
CP0480058 Compound Info	1-(4-fluorophenyl)-4-[(2S,8S)-14-methyl-1,5,14-triazatetracyclo[7.7.1.02,8.013,17]heptadeca-9(17),10,12-trien-5-yl]butan-1-one Show/Hide	C25H30FN3O	1
1	Ki = 148 nM Bioactivity Info	TI LI LO TS
CP0380845 Compound Info	8-(Methyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C17H22N2O	1
1	Ki = 151 nM Bioactivity Info	TI LI LO TS
CP0372726 Compound Info	(3aR,9bS)-3-Allyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indol-9-ol Show/Hide	C15H19NO	1
1	Ki = 153 nM Bioactivity Info	TI LI LO TS
CP0402279 Compound Info	(5,6-Dimethoxy-indan-2-yl)-(3-phenyl-propyl)-propyl-amine Show/Hide	C23H31NO2	1
1	Ki = 155 nM Bioactivity Info	TI LI LO TS
CP0406263 Compound Info	N-[2-(3-aminophenyl)ethyl]-5,6-dimethoxy-N-propyl-2,3-dihydro-1H-inden-2-amine Show/Hide	C22H30N2O2	1
1	Ki = 162 nM Bioactivity Info	TI LI LO TS
CP0381060 Compound Info	(5,6-Dimethoxy-indan-2-yl)-[2-(4-methoxy-phenyl)-ethyl]-propyl-amine Show/Hide	C23H31NO3	1
1	Ki = 163 nM Bioactivity Info	TI LI LO TS
CP0496697 Compound Info	N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclobutanecarbonylamino)-2-methoxybenzamide Show/Hide	C24H28ClN3O3	1
1	Ki = 170 nM Bioactivity Info	TI LI LO TS
CP0115744 Compound Info	3-[3-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]propyl]-1,2-benzoxazole Show/Hide	C24H28N4O	1
1	Ki = 174 nM Bioactivity Info	TI LI LO TS
CP0405581 Compound Info	N-[(3R)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclopropanecarbonylamino)-2-methoxybenzamide Show/Hide	C23H26ClN3O3	1
1	Ki = 190 nM Bioactivity Info	TI LI LO TS
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	2
1	Ki = 190 nM Bioactivity Info	TI LI LO TS
2	Ki = 260 nM Bioactivity Info	TI LI LO TS
CP0059921 Compound Info	6-fluoro-3-[3-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]propyl]-1,2-benzoxazole Show/Hide	C24H27FN4O	1
1	Ki = 192 nM Bioactivity Info	TI LI LO TS
CP0480064 Compound Info	(10R,15S)-12-[3-(4-fluorophenoxy)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-triene Show/Hide	C23H28FN3O	1
1	Ki = 213 nM Bioactivity Info	TI LI LO TS
CP0045414 Compound Info	N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclopropanecarbonylamino)-2-methoxybenzamide Show/Hide	C23H26ClN3O3	1
1	Ki = 220 nM Bioactivity Info	TI LI LO TS
CP0428818 Compound Info	8-(Cyclopropylmethyl-propyl-amino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C20H26N2O	1
1	Ki = 228 nM Bioactivity Info	TI LI LO TS
CP0401594 Compound Info	N-[(3R)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclobutanecarbonylamino)-2-methoxybenzamide Show/Hide	C24H28ClN3O3	1
1	Ki = 240 nM Bioactivity Info	TI LI LO TS
CP0480515 Compound Info	(8S)-8-(dimethylamino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C15H18N2O	1
1	Ki = 250 nM Bioactivity Info	TI LI LO TS
CP0444093 Compound Info	(5-Methoxy-indan-2-yl)-dipropyl-amine Show/Hide	C16H25NO	1
1	Ki = 263 nM Bioactivity Info	TI LI LO TS
CP0505503 Compound Info	4-{2-[(5,6-Dimethoxy-indan-2-yl)-propyl-amino]-ethyl}-thiazol-2-ylamine Show/Hide	C19H27N3O2S	1
1	Ki = 265 nM Bioactivity Info	TI LI LO TS
CP0434274 Compound Info	(5,6-Dimethoxy-indan-2-yl)-propyl-(2-pyridin-3-yl-ethyl)-amine Show/Hide	C21H28N2O2	1
1	Ki = 286 nM Bioactivity Info	TI LI LO TS
CP0444095 Compound Info	(5,6-Dimethoxy-indan-2-yl)-propyl-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine Show/Hide	C23H28F3NO2	1
1	Ki = 310 nM Bioactivity Info	TI LI LO TS
CP0409491 Compound Info	(5,6-Dimethoxy-indan-2-yl)-ethyl-propyl-amine Show/Hide	C16H25NO2	1
1	Ki = 374 nM Bioactivity Info	TI LI LO TS
CP0221880 Compound Info	(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 423 nM Bioactivity Info	TI LI LO TS
CP0453019 Compound Info	(3aR,9bS)-3-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole Show/Hide	C15H21N	1
1	Ki = 548 nM Bioactivity Info	TI LI LO TS
CP0489974 Compound Info	4-Benzoylamino-N-((S)-1-benzyl-pyrrolidin-3-yl)-5-chloro-2-methoxy-benzamide Show/Hide	C26H26ClN3O3	1
1	Ki = 630 nM Bioactivity Info	TI LI LO TS
CP0498130 Compound Info	N-[(3R)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclopentanecarbonylamino)-2-methoxybenzamide Show/Hide	C25H30ClN3O3	1
1	Ki = 690 nM Bioactivity Info	TI LI LO TS
CP0453454 Compound Info	N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclopentanecarbonylamino)-2-methoxybenzamide Show/Hide	C25H30ClN3O3	1
1	Ki = 740 nM Bioactivity Info	TI LI LO TS
CP0398731 Compound Info	4-fluoro-N-[2-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]ethyl]benzamide Show/Hide	C23H27FN4O	1
1	Ki = 767 nM Bioactivity Info	TI LI LO TS
CP0437569 Compound Info	(8S)-8-[4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)butyl-propylamino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde;hydrate Show/Hide	C27H37N3O3	1
1	Ki = 859 nM Bioactivity Info	TI LI LO TS
CP0288601 Compound Info	(5,6-Dimethoxy-indan-2-yl)-dipropyl-amine Show/Hide	C17H27NO2	1
1	Ki = 992 nM Bioactivity Info	TI LI LO TS
CP0376374 Compound Info	N-[(3S)-1-benzylpyrrolidin-3-yl]-5-chloro-4-(cyclohexanecarbonylamino)-2-methoxybenzamide Show/Hide	C26H32ClN3O3	1
1	Ki = 1200 nM Bioactivity Info	TI LI LO TS
CP0448199 Compound Info	(5,6-Dimethoxy-indan-2-yl)-propyl-thiophen-3-ylmethyl-amine Show/Hide	C19H25NO2S	1
1	Ki = 1244 nM Bioactivity Info	TI LI LO TS
CP0469225 Compound Info	(5,6-Dimethoxy-indan-2-yl)-(3-fluoro-propyl)-propyl-amine Show/Hide	C17H26FNO2	1
1	Ki = 1840 nM Bioactivity Info	TI LI LO TS
CP0474719 Compound Info	2,8-dimethyl-3-[2-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]ethyl]pyrido[1,2-a]pyrimidin-4-one Show/Hide	C26H31N5O	1
1	Ki = 3000 nM Bioactivity Info	TI LI LO TS
CP0376022 Compound Info	5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-(S)-pyrrolidin-3-yl-benzamide Show/Hide	C16H20ClN3O3	1
1	Ki = 14000 nM Bioactivity Info	TI LI LO TS
CP0462232 Compound Info	8-Pyrrolidin-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C17H20N2O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0497718 Compound Info	8-Azepan-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H24N2O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0398730 Compound Info	4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]-1-pyridin-4-ylbutan-1-one Show/Hide	C23H28N4O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0416215 Compound Info	(3aS,7aR)-2-[3-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]propyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione Show/Hide	C25H34N4O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0474717 Compound Info	(3aR,7aS)-2-[4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione Show/Hide	C26H36N4O2	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0480057 Compound Info	6-chloro-5-[2-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]ethyl]-1,3-dihydroindol-2-one Show/Hide	C24H27ClN4O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0480062 Compound Info	1-(4,4-difluoropiperidin-1-yl)-4-[(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one Show/Hide	C23H32F2N4O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000049 , C6

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0008601 Compound Info	4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) Show/Hide	C21H23ClFNO2	21
1	IC50 = 2.5 nM
2	IC50 = 5.5 nM
3	IC50 = 7 nM
4	IC50 = 7.5 nM
5	IC50 = 17.5 nM
6	IC50 = 18 nM
7	IC50 = 40 nM
8	Ki = 0.2 nM
9	Ki = 0.47 nM
10	Ki = 0.75 nM
11	Ki = 0.871 nM
12	Ki = 1.4 nM
13	Ki = 1.5 nM
14	Ki = 1.86 nM
15	Ki = 2.6 nM
16	Ki = 2.69 nM
17	Ki = 3.311 nM
18	Ki = 4 nM
19	Ki = 4.365 nM
20	Ki = 4.8 nM
21	Ki = 5.012 nM
CP0042751 Compound Info	(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol;hydrate;hydrochloride Show/Hide	C17H17NO2	9
1	IC50 = 2.6 nM
2	IC50 = 21 nM
3	IC50 = 24 nM
4	Ki = 1.8 nM
5	Ki = 2.2 nM
6	Ki = 11.1 nM
7	Ki = 13 nM
8	Ki = 17.3 nM
9	Ki = 98 nM
CP0077311 Compound Info	1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one Show/Hide	C22H24ClN5O2	1
1	IC50 = 5.2 nM
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	5
1	IC50 = 5.2 nM
2	Ki = 86 nM
3	Ki = 549.54 nM
4	Ki = 1357 nM
5	Ki = 3500 nM
CP0052226 Compound Info	1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-piperazine Show/Hide	C25H34N2O2	2
1	IC50 = 18 nM
2	IC50 = 20 nM
CP0310336 Compound Info	(+/-)-trans-4-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-7-ol Show/Hide	C16H23NO	1
1	IC50 = 34 nM
CP0033479 Compound Info	(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Show/Hide	C17H19ClN2S	4
1	IC50 = 40 nM
2	Ki = 1.995 nM
3	Ki = 4.97 nM
4	Ki = 10 nM
CP0056556 Compound Info	1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-4-phenyl-piperazine Show/Hide	C24H32N2O	2
1	IC50 = 96.7 nM
2	IC50 = 110 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	16
1	IC50 = 132 nM
2	IC50 = 290 nM
3	IC50 = 330 nM
4	IC50 = 410 nM
5	IC50 = 440 nM
6	IC50 = 830 nM
7	IC50 = 2108 nM
8	Ki = 34 nM
9	Ki = 45.71 nM
10	Ki = 53.6 nM
11	Ki = 82 nM
12	Ki = 210 nM
13	Ki = 250 nM
14	Ki = 251.19 nM
15	Ki = 263.03 nM
16	Ki = 319 nM
CP0038828 Compound Info	1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-4-pyridin-2-yl-piperazine Show/Hide	C23H31N3O	2
1	IC50 = 140 nM
2	IC50 = 177 nM
CP0036921 Compound Info	3-HYDROXYTYRAMINE HYDROCHLORIDE Show/Hide	C8H11NO2	1
1	IC50 = 1200 nM
CP0118587 Compound Info	6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol; hydrochloride Show/Hide	C19H21NO2	4
1	Ki = 0.18 nM
2	Ki = 0.8 nM
3	Ki = 10 nM
4	Ki = 54 nM
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	4
1	Ki = 20 nM
2	Ki = 39 nM
3	Ki = 63.1 nM
4	Ki = 69 nM
CP0127400 Compound Info	(-)-Pramipexole Show/Hide	C10H17N3S	1
1	Ki = 39 nM
CP0162854 Compound Info	(+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol Show/Hide	C16H25NO	2
1	Ki = 54 nM
2	Ki = 142 nM
CP0056626 Compound Info	(8R)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C18H26N2	1
1	Ki = 100 nM
CP0052478 Compound Info	(+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 120 nM
CP0216619 Compound Info	(8S)-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C18H26N2	1
1	Ki = 146 nM
CP0258010 Compound Info	(+/-)-Dipropyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C18H26N2	1
1	Ki = 156 nM
CP0064163 Compound Info	(8R)-N,N-dimethyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C14H18N2	1
1	Ki = 170 nM
CP0271827 Compound Info	(+/-)-Dimethyl-(6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-amine Show/Hide	C14H18N2	1
1	Ki = 300 nM
CP0348071 Compound Info	(1-Chloro-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine Show/Hide	C18H25ClN2	1
1	Ki = 317 nM
CP0276816 Compound Info	(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 382 nM
CP0065057 Compound Info	(R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 419 nM
CP0043151 Compound Info	8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 439 nM
CP0216553 Compound Info	N,N-dipropyl-1-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C20H27F3N2	1
1	Ki = 796 nM
CP0044323 Compound Info	(8S)-N,N-dimethyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine Show/Hide	C14H18N2	1
1	Ki = 1580 nM
CP0221880 Compound Info	(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbaldehyde Show/Hide	C19H26N2O	1
1	Ki = 3592 nM
CP0099933 Compound Info	(S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]indole-1-carbonitrile Show/Hide	C19H25N3	1
1	Ki = 8015 nM

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT00867	D(2) dopamine receptor	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han