General Information of the Protein
Protein ID
PT00867
Protein Name
D(2) dopamine receptor
Secondarily
Protein Name
Dopamine D2 receptor
Gene Name
DRD2
Sequence
MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Function
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (PubMed:30936473).
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Uniprot ID
Primary ID:
P61168

Secondarily ID:
P13953
Q0VGH9
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Ensembl ID
ENSG00000149295
Subcellular Location
Cell membrane
Golgi apparatus membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000035 , NIH 3T3
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0050763
 Compound Info 
1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine
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C21H21N
  1
1
Ki = 112 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0036757
 Compound Info 
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
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C19H24N2
  1
1
Ki = 726 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0157151
 Compound Info 
9,10-dihydroanthracene(DHA), 1a
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C15H15N
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT00957 D(2) dopamine receptor Rattus norvegicus, Rat
 Protein Info