General Information of the Compound
Compound ID
CP0472164
Compound Name
5-Chloro-4-(cyclopropanecarbonyl-amino)-2-methoxy-N-((S)-1-phenethyl-pyrrolidin-3-yl)-benzamide
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Structure
Formula
C24H28ClN3O3
Molecular Weight
441.959
Canonical SMILES
COc1cc(NC(=O)C2CC2)c(Cl)cc1C(=O)N[C@H]1CCN(CCc2ccccc2)C1
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InChI
InChI=1S/C24H28ClN3O3/c1-31-22-14-21(27-23(29)17-7-8-17)20(25)13-19(22)24(30)26-18-10-12-28(15-18)11-9-16-5-3-2-4-6-16/h2-6,13-14,17-18H,7-12,15H2,1H3,(H,26,30)(H,27,29)/t18-/m0/s1
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InChIKey
UIDILJWJRJJVSD-SFHVURJKSA-N
Physicochemical Property
logP
3.7439
Rotatable Bonds
8
Heavy Atom Count
31
Polar Areas
70.67
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10741841
SID: 15778172
ChEMBL ID
CHEMBL91859
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00957, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 82 nM
   TI
   LI
   LO
   TS
Protein ID: PT01366, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 33 nM
   TI
   LI
   LO
   TS
Protein ID: PT01161, D(4) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 3.4 nM
   TI
   LI
   LO
   TS