General Information of the Compound
Compound ID
CP0056556
Compound Name
1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-4-phenyl-piperazine
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Structure
Formula
C24H32N2O
Molecular Weight
364.533
Canonical SMILES
COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc12
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InChI
InChI=1S/C24H32N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,10-12,14,20H,5,7-9,13,15-19H2,1H3
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InChIKey
JGCUFOXBUYJGBX-UHFFFAOYSA-N
Physicochemical Property
logP
4.7175
Rotatable Bonds
6
Heavy Atom Count
27
Polar Areas
15.71
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10361439
SID: 15374708
ChEMBL ID
CHEMBL322275
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00957, D(2) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 110 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 96.7 nM
2 IC50 = 110 nM