Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone
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 PubChem ID
CID: 135398737
SID: 14826474
Canonical SMILES
CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
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Compound Formula C18H19ClN4
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P28223
Gene Name
HTR2A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000234 AU-BEK
 Cell Line Info 
Bos taurus (Bovine)  2
1
IC50 = 12 nM
   TI
   LI
   LO
   TS
2
Ki = 5 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
Ki = 4.84 nM
   TI
   LI
   LO
   TS
2
Ki = 5.012 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
Ki = 13 nM
   TI
   LI
   LO
   TS
2
Ki = 33 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 15 nM
   TI
   LI
   LO
   TS
2
Ki = 18 nM
   TI
   LI
   LO
   TS
CL000065 HEK293-EBNA
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 9.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Activity = 5.4 nM
2 Ki = 1.4 nM
3 Ki = 2.692 nM
4 Ki = 3 nM
5 Ki = 3.03 nM
6 Ki = 3.3 nM
7 Ki = 4 nM
8 Ki = 5.35 nM
9 Ki = 6.3 nM
10 Ki = 7.8 nM
11 Ki = 8.57 nM
12 Ki = 8.9 nM
13 Ki = 9.12 nM
14 Ki = 9.6 nM
15 Ki = 10 nM
16 Ki = 15 nM
17 Ki = 24 nM
18 Ki = 230 nM