Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone

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PubChem ID

CID: 135398737

SID: 14826474

Canonical SMILES	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 Show/Hide
Compound Formula	C18H19ClN4

Compound Structure

Protein Name

Protein Info

D(2) dopamine receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Dopamine receptor

Uniprot ID

P14416

Gene Name

DRD2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	10
1	Ki = 28 nM	TI LI LO TS
2	Ki = 39 nM	TI LI LO TS
3	Ki = 41 nM	TI LI LO TS
4	Ki = 74 nM	TI LI LO TS
5	Ki = 83 nM	TI LI LO TS
6	Ki = 125.89 nM	TI LI LO TS
7	Ki = 155 nM	TI LI LO TS
8	Ki = 208 nM	TI LI LO TS
9	Ki = 254 nM	TI LI LO TS
10	Ki = 389 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	Ki = 91 nM	TI LI LO TS
CL000053	COS-7 Cell Line Info	Chlorocebus aethiops (Green monkey)	1
1	Ki = 220 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	3
1	Ki = 71 nM	TI LI LO TS
2	Ki = 72 nM	TI LI LO TS
3	Ki = 150 nM	TI LI LO TS
CL000013	Sf9 Cell Line Info	Spodoptera frugiperda (Fall armyworm)	1
1	Ki = 372 nM	TI LI LO TS

Biochemical Assays