Protein Information

General Information of the Protein

Protein ID	PT00941
Protein Name	5-hydroxytryptamine receptor 7
Secondarily Protein Name	5-HT-X Serotonin receptor 7
Gene Name	HTR7
Sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Membrane receptor > Family A G protein-coupled receptor > Small molecule receptor (family A GPCR) > Monoamine receptor > Serotonin receptor
Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Show/Hide
Uniprot ID	Primary ID: P34969 Secondarily ID: B5BUP6 P78336 P78372 P78516 Q5VX01 Q5VX02 Q5VX03 Show/Hide
Ensembl ID	ENSG00000148680
HGNC ID	HGNC:5302
Subcellular Location	Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000901 , 661W

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0391130 Compound Info	(3aS,9bS)-3,3a-dimethyl-5-phenyl-1,2,4,9b-tetrahydropyrrolo[2,3-c]quinoline Show/Hide	C19H22N2	1
1	Ki = 2.692 nM Bioactivity Info	TI LI LO TS
CP0426378 Compound Info	(3aS,9bS)-3,3a-dimethyl-6-phenyl-1,2,4,9b-tetrahydrochromeno[3,4-b]pyrrole Show/Hide	C19H21NO	1
1	Ki = 19.95 nM Bioactivity Info	TI LI LO TS
CP0426383 Compound Info	(3aS,9bS)-3a-methyl-6-phenyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole Show/Hide	C18H19NO	1
1	Ki = 23.44 nM Bioactivity Info	TI LI LO TS
CP0426380 Compound Info	(3aS,9bS)-8-methoxy-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole Show/Hide	C13H17NO2	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0426405 Compound Info	(3aS,9bS)-3a,8-dimethyl-5-(4-methylphenyl)-2,3,4,9b-tetrahydro-1H-pyrrolo[2,3-c]quinoline Show/Hide	C20H24N2	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0432125 Compound Info	(3aS,9bS)-8-bromo-5-(4-bromophenyl)-3a-methyl-2,3,4,9b-tetrahydro-1H-pyrrolo[2,3-c]quinoline Show/Hide	C18H18Br2N2	1
1	Ki = 199.53 nM Bioactivity Info	TI LI LO TS
CP0426384 Compound Info	(3aS,9bS)-6-bromo-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole Show/Hide	C12H14BrNO	1
1	Ki = 398.11 nM Bioactivity Info	TI LI LO TS
CP0426421 Compound Info	(1S,2S)-1-ethyl-2-methyl-1,3-dihydrobenzo[f]chromen-2-amine Show/Hide	C16H19NO	1
1	Ki = 691.83 nM Bioactivity Info	TI LI LO TS
CP0411059 Compound Info	(3S,4S)-4-ethyl-3-methyl-1-phenyl-2,4-dihydroquinolin-3-amine Show/Hide	C18H22N2	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0426385 Compound Info	(3aS,9bS)-3a-methyl-8-phenyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole Show/Hide	C18H19NO	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0455600 Compound Info	(3S,4S)-4-ethyl-3-methyl-2,4-dihydrobenzo[h]chromen-3-amine Show/Hide	C16H19NO	1
1	Ki = 1000 nM Bioactivity Info	TI LI LO TS
CP0391154 Compound Info	(3aS,9bS)-7,9-dimethoxy-3a-methyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole Show/Hide	C14H19NO3	1
1	Ki = 1258.93 nM Bioactivity Info	TI LI LO TS
CP0426382 Compound Info	(3aS,9bS)-3a,7,9-trimethyl-2,3,4,9b-tetrahydro-1H-chromeno[3,4-b]pyrrole Show/Hide	C14H19NO	1
1	Ki = 1258.93 nM Bioactivity Info	TI LI LO TS
CP0391120 Compound Info	(1S,2R)-1-ethyl-7-methoxy-2-methyl-3,4-dihydro-1H-naphthalen-2-amine Show/Hide	C14H21NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS
CP0391121 Compound Info	(3S,4S)-4-ethyl-3,6-dimethyl-2,4-dihydrochromen-3-amine Show/Hide	C13H19NO	1
1	Ki > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000011 , CHO

Cell Line Info

Cell Line ID: CL000026 , CHO-K1

Cell Line Info

Cell Line ID: CL000053 , COS-7

Cell Line Info

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000729 , HEK293-CNG

Cell Line Info

Cell Line ID: CL000065 , HEK293-EBNA

Cell Line Info

Cell Line ID: CL000131 , HEK293-F

Cell Line Info

Cell Line ID: CL000017 , HeLa

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0036542 Compound Info	(phenylmethyl) N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-yl]methyl]carbamate Show/Hide	C25H29N3O2	2
1	Activity = 18 nM
2	Ki = 6.31 nM
CP0001238 Compound Info	14C-5-hydroxy tryptamine creatinine disulfate Show/Hide	C10H12N2O	10
1	IC50 = 0.29 nM
2	IC50 = 0.49 nM
3	IC50 = 0.61 nM
4	IC50 = 1.5 nM
5	Ki = 0.11 nM
6	Ki = 0.13 nM
7	Ki = 0.22 nM
8	Ki = 3.162 nM
9	Ki = 4 nM
10	Ki = 8.1 nM
CP0037955 Compound Info	METHIOTHEPIN Show/Hide	C20H24N2S2	2
1	IC50 = 3.1 nM
2	Ki = 3.7 nM
CP0176519 Compound Info	(4R,5S)-4-(1H-imidazol-5-ylmethyl)-5-methyl-2-phenyl-4,5-dihydro-1,3-thiazole Show/Hide	C14H15N3S	1
1	IC50 > 10000 nM
CP0315737 Compound Info	2-[4-(1H-imidazol-5-ylmethyl)-5-phenyl-4,5-dihydro-1,3-thiazol-2-yl]phenol Show/Hide	C19H17N3OS	1
1	IC50 > 10000 nM
CP0408362 Compound Info	(4S,5S)-4-(1H-imidazol-5-ylmethyl)-5-methyl-2-phenyl-4,5-dihydro-1,3-thiazole Show/Hide	C14H15N3S	1
1	IC50 > 10000 nM
CP0096286 Compound Info	(R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidin-1-ylsulfonyl)phenol Show/Hide	C18H28N2O3S	5
1	Kd = 9.7 nM
2	Ki = 1 nM
3	Ki = 1.25 nM
4	Ki = 1.26 nM
5	Ki = 1.3 nM
CP0237538 Compound Info	2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole Show/Hide	C21H24N2	1
1	Ki = 0.153 nM
CP0099712 Compound Info	3-(2-aminoethyl)-1H-indole-5-carboxamide Show/Hide	C11H13N3O	4
1	Ki = 0.3981 nM
2	Ki = 0.9 nM
3	Ki = 0.93 nM
4	Ki < 10 nM
CP0455867 Compound Info	CAS_441351-20-8 Show/Hide	C28H36N4O2S	1
1	Ki = 0.5 nM
CP0074213 Compound Info	2-(6-Phenylpyridin-2-ylthio)-N,N-dimethylethan-amine Show/Hide	C15H18N2S	1
1	Ki = 0.6 nM
CP0169088 Compound Info	(2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine Show/Hide	C18H25N3	1
1	Ki = 0.6 nM
CP0096742 Compound Info	3-[1-[2-[(2R)-1-(1H-indol-6-ylsulfonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl]-1H-indole Show/Hide	C27H32N4O2S	1
1	Ki = 0.6761 nM
CP0052721 Compound Info	1-[(E)-6-(3,4-dihydro-1H-isoquinolin-2-yl)hex-3-enyl]-3H-indol-2-one Show/Hide	C23H26N2O	1
1	Ki = 0.7 nM
CP0109472 Compound Info	3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-6-fluoro-1H-indol-2-one Show/Hide	C24H29ClFN3O	1
1	Ki = 0.79 nM
CP0080064 Compound Info	(1R,5aR)-1-methoxy-1,6-dimethyl-1,5,5a,6,7,8-hexahydro-6-aza-benzo[mno]aceanthrylene Show/Hide	C20H21NO	1
1	Ki = 1.1 nM
CP0194931 Compound Info	1-(2-phenylphenyl)piperazine Show/Hide	C16H18N2	1
1	Ki = 1.4 nM
CP0122899 Compound Info	2a-[4-(4-pyridin-2-ylpiperazin-1-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one Show/Hide	C24H30N4O	1
1	Ki = 1.995 nM
CP0168742 Compound Info	2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)-2a,3,4,5-tetrahydrobenzo[cd]indol-2(1H)-one Show/Hide	C26H30N2O	5
1	Ki = 1.995 nM
2	Ki = 2 nM
3	Ki = 2.13 nM
4	Ki = 2.14 nM
5	Ki = 3.311 nM
CP0034894 Compound Info	2-(5-methoxy-1H-indol-3-yl)ethanamine Show/Hide	C11H14N2O	1
1	Ki = 2 nM
CP0061062 Compound Info	6-(2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethyl}-pyrrolidine-1-sulfonyl)-1H-indole; hydrochloride Show/Hide	C25H30ClN3O3S	1
1	Ki = 2 nM
CP0035412 Compound Info	2a-[4-(4-phenylpiperazin-1-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one Show/Hide	C25H31N3O	2
1	Ki = 2.138 nM
2	Ki = 3.162 nM
CP0207251 Compound Info	6-{(R)-2-[2-(4-Methyl-piperidin-1-yl)-ethyl]-pyrrolidine-1-sulfonyl}-1H-indole Show/Hide	C20H29N3O2S	1
1	Ki = 2.4 nM
CP0098784 Compound Info	N,N-dimethyl-2-[3-(1,3,5-trimethylpyrazol-4-yl)phenyl]ethanamine Show/Hide	C16H23N3	1
1	Ki = 2.5 nM
CP0238957 Compound Info	1-[2-(4-methoxyphenyl)phenyl]piperazine Show/Hide	C17H20N2O	1
1	Ki = 2.6 nM
CP0048180 Compound Info	2-[2-(6-Bromo-indol-1-yl)-ethyl]-decahydro-pyrido[1,2-a][1,4]diazepine Show/Hide	C19H26BrN3	1
1	Ki = 3 nM
CP0182705 Compound Info	(R)-4-Methyl-1-(2-(1-toluene-3-sulfonyl)-pyrrolidin-2-yl)-ethyl)-piperidine (Oxalate salt) Show/Hide	C19H30N2O2S	3
1	Ki = 3 nM
2	Ki = 3.16 nM
3	Ki = 3.2 nM
CP0692353 Compound Info	5-(4-fluorophenyl)-3-(2-hydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-5-methylimidazolidine-2,4-dione Show/Hide	C24H29FN4O4	1
1	Ki = 3 nM
CP0193536 Compound Info	2-[4-[4-(2-oxo-1,3,4,5-tetrahydrobenzo[cd]indol-2a-yl)butyl]piperazin-1-yl]benzonitrile Show/Hide	C26H30N4O	1
1	Ki = 3.981 nM
CP0208718 Compound Info	N-methyl-2-[2-[4-(2-oxo-1,3,4,5-tetrahydrobenzo[cd]indol-2a-yl)butyl]-3,4-dihydro-1H-pyrido[3,4-b]indol-9-yl]acetamide Show/Hide	C29H34N4O2	1
1	Ki = 4 nM
CP0366518 Compound Info	2-(6-Bromopyridin-2-ylthio)-N,N-dimethylethanamine Show/Hide	C9H13BrN2S	1
1	Ki = 4.1 nM
CP0039958 Compound Info	(risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one Show/Hide	C23H27FN4O2	2
1	Ki = 4.3 nM
2	Ki = 10 nM
CP0062956 Compound Info	2a-[3-(4-Phenyl-piperazin-1-yl)-propyl]-2a,3,4,5-tetrahydro-1H-benzo[cd]indol-2-one Show/Hide	C24H29N3O	2
1	Ki = 5 nM
2	Ki = 5.012 nM
CP0367059 Compound Info	2a-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one Show/Hide	C26H33N3O2	1
1	Ki = 5.012 nM
CP0056386 Compound Info	5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one Show/Hide	C21H21ClN4OS	1
1	Ki = 6 nM
CP0193110 Compound Info	2-[2-(6-Trifluoromethyl-indol-1-yl)-ethyl]-decahydro-pyrido[1,2-a][1,4]diazepine Show/Hide	C20H26F3N3	1
1	Ki = 7 nM
CP0041133 Compound Info	6-chloro-2a-[4-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one Show/Hide	C26H28Cl2N2O	2
1	Ki = 7.24 nM
2	Ki = 7.244 nM
CP0031743 Compound Info	1H-imidazo[4,5-c]pyridine derivative Show/Hide	C18H26N4O2S	1
1	Ki = 7.943 nM
CP0017601 Compound Info	2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole Show/Hide	C21H25N3	1
1	Ki = 8 nM
CP0038868 Compound Info	2-[3-(2,6-dimethoxyphenyl)phenyl]-N,N-dimethylethanamine Show/Hide	C18H23NO2	1
1	Ki = 8.6 nM
CP0025667 Compound Info	2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone Show/Hide	C18H19ClN4	7
1	Ki = 9 nM
2	Ki = 12.59 nM
3	Ki = 39.81 nM
4	Ki = 40 nM
5	Ki = 45.5 nM
6	Ki = 48 nM
7	Ki = 100 nM
CP0091593 Compound Info	2a-[4-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)butyl]-1-methyl-4,5-dihydro-3H-benzo[cd]indol-2-one Show/Hide	C23H28N2OS	1
1	Ki = 9.7 nM
CP0198069 Compound Info	(R)-4-Methyl-1-(2-(1-(naphthalene-1-sulfonyl)-pyrrolidin-2-yl)-ethyl)-piperidine(10) Show/Hide	C22H30N2O2S	1
1	Ki = 10 nM
CP0301386 Compound Info	2-[2-(6-Chloro-indol-1-yl)-ethyl]-decahydro-pyrido[1,2-a][1,4]diazepine Show/Hide	C19H26ClN3	1
1	Ki = 10 nM
CP0183361 Compound Info	(6aR,9R)-5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid diethylamide Show/Hide	C20H24BrN3O	2
1	Ki = 10 nM
2	Ki = 30 nM
CP0042927 Compound Info	7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one Show/Hide	C23H27Cl2N3O2	3
1	Ki = 10.3 nM
2	Ki = 14 nM
3	Ki = 100 nM
CP0427995 Compound Info	Amisulpride Show/Hide	C17H27N3O4S	1
1	Ki = 11.5 nM
CP0037301 Compound Info	CHEBI:584020 Show/Hide	C21H27N3O2	1
1	Ki = 12.59 nM
CP0070944 Compound Info	N-[(4-cyanophenyl)methyl]-6-[4-(2-phenylphenyl)piperazin-1-yl]hexanamide Show/Hide	C30H34N4O	1
1	Ki = 15 nM
CP0079728 Compound Info	5-chloro-4-methyl-1,4-dihydroquinazolin-2-amine Show/Hide	C9H10ClN3	1
1	Ki = 15.85 nM
CP0245665 Compound Info	(R)-1-(2-(1-(3-methoxy-benzenesulfonyl)-pyrrolidin-2-yl)-ethyl-4-methyl piperidine Show/Hide	C19H30N2O3S	1
1	Ki = 18 nM
CP0658701 Compound Info	1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine Hydrochloride Show/Hide	C18H23ClN2S	1
1	Ki = 19 nM
CP0086335 Compound Info	4-[(2S)-2-[2-[4-(1-benzothiophen-4-yl)piperazin-1-yl]ethyl]pyrrolidin-1-yl]sulfonylisoquinoline Show/Hide	C27H30N4O2S2	1
1	Ki = 19 nM
CP0394360 Compound Info	1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine Show/Hide	C18H22N2S	1
1	Ki = 19 nM
CP0040671 Compound Info	8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Show/Hide	C23H26FN3O2	2
1	Ki = 19.95 nM
2	Ki = 110 nM
CP0083136 Compound Info	1-(2-Methoxy-phenyl)-4-(1-o-tolyl-1H-pyrrol-3-ylmethyl)-piperazine Show/Hide	C23H27N3O	1
1	Ki = 21 nM
CP0033479 Compound Info	(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Show/Hide	C17H19ClN2S	1
1	Ki = 27 nM
CP0156235 Compound Info	3,N-Dimethyl-N-[(R)-1-methyl-3-(4-methyl-piperidin-1-yl)-propyl]-benzenesulfonamide Show/Hide	C18H30N2O2S	2
1	Ki = 31.6 nM
2	Ki = 32 nM
CP0233824 Compound Info	4-Methoxy-N-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-benzenesulfonamide Show/Hide	C21H29N3O4S	1
1	Ki = 37 nM
CP0050763 Compound Info	1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine Show/Hide	C21H21N	1
1	Ki = 50.12 nM
CP0035893 Compound Info	(Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine Show/Hide	C21H26N2S2	1
1	Ki = 70 nM
CP0241765 Compound Info	1-carbazol-9-yl-6-[4-(2-methoxyphenyl)piperazin-1-yl]hexan-1-one;hydrochloride Show/Hide	C29H34ClN3O2	1
1	Ki = 74 nM
CP0122652 Compound Info	3-[3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl]-5-(4-fluorophenyl)-5-methylimidazolidine-2,4-dione Show/Hide	C30H33FN4O3	1
1	Ki = 79 nM
CP0002071 Compound Info	N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-prop-2-enylprop-2-en-1-amine Show/Hide	C17H22N2O	1
1	Ki = 89.13 nM
CP0183573 Compound Info	2a-[2-(4-phenylpiperazin-1-yl)ethyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one Show/Hide	C23H27N3O	1
1	Ki = 100 nM
CP0041243 Compound Info	5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride Show/Hide	C20H22ClN3O3S2	1
1	Ki = 260 nM
CP0045063 Compound Info	2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine Show/Hide	C17H20N4S	2
1	Ki = 365 nM
2	Ki = 1000 nM
CP0276528 Compound Info	(S)-4-Methyl-1-(2-(1-(naphthalene-1-sulfonyl)-pyrrolidin-2-yl)-ethyl)-piperidine(10) Show/Hide	C22H30N2O2S	1
1	Ki = 400 nM
CP0037227 Compound Info	7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol Show/Hide	C16H25NO	1
1	Ki = 466 nM
CP0045069 Compound Info	2-[1-(benzenesulfonyl)-5-methoxyindol-3-yl]-N,N-dimethylethanamine Show/Hide	C19H22N2O3S	1
1	Ki = 600 nM
CP0040250 Compound Info	2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol Show/Hide	C21H25N3O2S	1
1	Ki = 1000 nM
CP0055933 Compound Info	3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione Show/Hide	C22H22FN3O3	1
1	Ki = 1334 nM
CP0311262 Compound Info	2a-[4-(4-cyclohexylpiperazin-1-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one Show/Hide	C25H37N3O	1
1	Ki = 100000 nM

Clinical Information about the Protein

Target 1 ( 5-HT 7 receptor (HTR7) )

Target Type	Clinical trial Target
Disease	2 Target-related Diseases				2
1	Major depressive disorder [ICD-11: 6A70.3]
2	Sleep-wake disorder [ICD-11: 7A00-7B2Z]
Clinical Trial Drug(s)	1 Clinical Trial Drug				1
1	JNJ-18038683	Drug Info	Phase 2	Major depressive disorder
Discontinued Drug(s)	1 Discontinued Drug				1
1	SB-269970	Drug Info	Terminated	Sleep-wake disorder

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT01746	5-hydroxytryptamine receptor 7	Rattus norvegicus, Rat	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han