General Information of the Protein
Protein ID
PT06956
Protein Name
5-hydroxytryptamine receptor 6
Secondarily
Protein Name
Serotonin receptor 6
Gene Name
HTR6
Sequence
MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN
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Organism
Mus musculus, Mouse
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (PubMed:25078650). Is an activator of TOR signaling (PubMed:23027611).
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Uniprot ID
Q9R1C8
Ensembl ID
ENSG00000158748
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0310110
 Compound Info 
SB-258585
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C18H22IN3O3S
  4
1
Ki = 0.32 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 0.75 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
3
Ki = 54 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
4
Ki = 114 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0439120
 Compound Info 
[4-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-naphthalen-1-ylmethanone
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C23H22N4O
  2
1
Ki = 5 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
2
Ki = 34 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01354 5-hydroxytryptamine receptor 6 Homo sapiens, Human
 Protein Info 
PT02228 5-hydroxytryptamine receptor 6 Rattus norvegicus, Rat
 Protein Info