General Information of the Compound
Compound ID
CP0276427
Compound Name
10-(benzenesulfonyl)-11-methylsulfanyl-2-piperazin-1-yl-1,8,12-triazatricyclo[7.3.0.03,7]dodeca-2,7,9,11-tetraene
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Structure
Formula
C20H23N5O2S2
Molecular Weight
429.571
Canonical SMILES
CSc1nn2c(N3CCNCC3)c3CCCc3nc2c1S(=O)(=O)c1ccccc1
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InChI
InChI=1S/C20H23N5O2S2/c1-28-19-17(29(26,27)14-6-3-2-4-7-14)18-22-16-9-5-8-15(16)20(25(18)23-19)24-12-10-21-11-13-24/h2-4,6-7,21H,5,8-13H2,1H3
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InChIKey
PPPVADQGCXVIIG-UHFFFAOYSA-N
Physicochemical Property
logP
2.1823
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
79.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 6918479
SID: 12015350
ChEMBL ID
CHEMBL1642114
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 0.85 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 2.512 nM