General Information of the Protein
Protein ID
PT06244
Protein Name
Galanin receptor type 1
Gene Name
GALR1
Secondarily
Gene Name
Galnr
Galnr1
Sequence
MELAPVNLSEGNGSDPEPPAEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLFHRDSNQTFCWEHWPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPLTPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCRVCNESPHGDAKEKNRIDTPPSTNCTHV
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Organism
Rattus norvegicus, Rat
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Galanin receptor
Function
Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
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Uniprot ID
Q62805
Subcellular Location
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0285142
 Compound Info 
(R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)propyl)(methyl)amino)acetic acid
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C24H24FNO3
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0441398
 Compound Info 
(3S,6S,9S,12S)-3-benzyl-9,12-di-sec-butyl-6-((2S,3R)-3-hydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
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C27H42N4O5
  1
1
IC50 = 3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0437601
 Compound Info 
(3S,6S,9S,12S)-3-benzyl-12-sec-butyl-6-((2S,3R)-3-hydroxybutan-2-yl)-9-isopropyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
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C26H40N4O5
  1
1
IC50 = 10.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476238
 Compound Info 
(3S,6S,9S,12S)-3-benzyl-6-((2S,3R)-3-hydroxybutan-2-yl)-9,12-diisopropyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
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C25H38N4O5
  1
1
IC50 = 11.1 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0474576
 Compound Info 
(3S,6S,9S,12S)-3-benzyl-9-sec-butyl-6-((2S,3R)-3-hydroxybutan-2-yl)-12-isopropyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
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C26H40N4O5
  1
1
IC50 = 11.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0456132
 Compound Info 
(S)-2-((2S,5S,8S,11S)-5-benzyl-8,11-di-sec-butyl-3,6,9,12-tetraoxo-1,4,7,10-tetraazacyclododecan-2-yl)-3-oxobutane-1-sulfonic acid
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C27H40N4O8S
  1
1
IC50 = 20.4 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0497907
 Compound Info 
(3S,6S,9S,12S)-3-benzyl-6,9,12-tri-sec-butyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
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C27H42N4O4
  1
1
IC50 = 29.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0476239
 Compound Info 
(3S,6S,9S,15aR)-9-sec-butyl-6-((1-methoxy-1H-indol-3-yl)methyl)-3-(5-oxohexyl)octahydro-1H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(12H,13H,14H)-tetraone
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C32H45N5O6
  1
1
IC50 = 94.6 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01961 Galanin receptor type 1 Homo sapiens, Human
 Protein Info