General Information of the Protein
Protein ID
PT01452
Protein Name
Retinoic acid receptor beta
Secondarily
Protein Name
HBV-activated protein
Nuclear receptor subfamily 1 group B member 2
RAR-epsilon
Gene Name
RARB
Secondarily
Gene Name
HAP
NR1B2
Sequence
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
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Organism
Homo sapiens, Human
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group B
>
Nuclear hormone receptor subfamily 1 group B member 2
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
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Uniprot ID
Primary ID:
P10826

Secondarily ID:
P12891
Q00989
Q15298
Q9UN48
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Ensembl ID
ENSG00000077092
HGNC ID
HGNC:9865
Subcellular Location
Nucleus
Cytoplasm
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000044 , CV-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0718144
 Compound Info 
4-[3-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-4,5-dihydro-isoxazol-5-yl]-benzoic acid
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C25H29NO3
  1
1
AC50 < 1 nM
 Bioactivity Info 
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CP0742222
 Compound Info 
4'-Methyl-3'-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-biphenyl-4-carboxylic acid
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C28H30O2
  1
1
AC50 < 1 nM
 Bioactivity Info 
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CP0042977
 Compound Info 
9-cis retinoic acid
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C20H28O2
  3
1
AC50 = 2 nM
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2
EC50 = 29 nM
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3
EC50 = 50 nM
 Bioactivity Info 
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CP0723268
 Compound Info 
3'-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-biphenyl-4-carboxylic acid
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C27H28O2
  1
1
AC50 = 4.3 nM
 Bioactivity Info 
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CP0742480
 Compound Info 
4'-Methyl-3'-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-biphenyl-4-carboxylic acid
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C29H32O2
  1
1
AC50 = 10 nM
 Bioactivity Info 
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CP0756887
 Compound Info 
4-[Cyclopropylidene-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C25H28O2
  1
1
AC50 = 17 nM
 Bioactivity Info 
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CP0041093
 Compound Info 
(E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzoic acid
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C24H28O2
  2
1
AC50 = 22 nM
 Bioactivity Info 
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2
EC50 = 3 nM
 Bioactivity Info 
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CP0042771
 Compound Info 
5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[2,2']binaphthalenyl-6-carboxylic acid
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C25H26O2
  1
1
AC50 = 52 nM
 Bioactivity Info 
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CP0648950
 Compound Info 
4-[6-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-pyridin-2-yl]-benzoic acid
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C26H27NO2
  1
1
AC50 = 140 nM
 Bioactivity Info 
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CP0715557
 Compound Info 
4-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-thiazol-5-yl]-benzoic acid
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C25H27NO2S
  1
1
AC50 = 740 nM
 Bioactivity Info 
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CP0041422
 Compound Info 
4-[2-Methyl-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C25H30O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0049341
 Compound Info 
4-[2-Methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C26H32O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0299470
 Compound Info 
4-[Cyclopropylidene-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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C26H30O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0730002
 Compound Info 
5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[1,2']binaphthalenyl-6-carboxylic acid
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C25H26O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0734985
 Compound Info 
4-[(Z)-3-Methyl-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-but-1-enyl]-benzoic acid
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C26H32O2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0806169
 Compound Info 
4-[6-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-pyridin-2-yl]-benzoic acid
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C27H29NO2
  1
1
AC50 > 1000 nM
 Bioactivity Info 
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CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
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C20H28O2
  3
1
EC50 = 1 nM
 Bioactivity Info 
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2
EC50 = 78 nM
 Bioactivity Info 
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3
EC50 = 80 nM
 Bioactivity Info 
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CP0042976
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
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C24H32O2
  1
1
EC50 = 17 nM
 Bioactivity Info 
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CP0403151
 Compound Info 
4-[(E)-2-(3,3-Dimethyl-2,3-dihydro-benzo[b]thiophen-5-yl)-propenyl]-benzoic acid
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C20H20O2S
  1
1
EC50 = 18 nM
 Bioactivity Info 
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CP0377408
 Compound Info 
(2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoic acid
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C20H24O2S
  1
1
EC50 = 43 nM
 Bioactivity Info 
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CP0414842
 Compound Info 
(2E,4E,6E)-7-(4,4-Dimethyl-chroman-6-yl)-3-methyl-octa-2,4,6-trienoic acid
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C20H24O3
  1
1
EC50 = 72 nM
 Bioactivity Info 
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CP0377308
 Compound Info 
4-[(E)-2-(4,4-Dimethyl-thiochroman-6-yl)-propenyl]-benzoic acid methyl ester
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C22H24O2S
  1
1
EC50 = 110 nM
 Bioactivity Info 
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CP0063990
 Compound Info 
(2E,4E)-6-[1-(3,5-Di-tert-butyl-phenyl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
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C24H34O2
  1
1
EC50 = 139 nM
 Bioactivity Info 
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CP0448523
 Compound Info 
4-[(E)-2-(4,4-Dimethyl-chroman-6-yl)-propenyl]-benzoic acid methyl ester
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C22H24O3
  1
1
EC50 = 140 nM
 Bioactivity Info 
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CP0493334
 Compound Info 
4-[(E)-2-(4,4-Dimethyl-chroman-6-yl)-propenyl]-benzoic acid
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C21H22O3
  1
1
EC50 = 190 nM
 Bioactivity Info 
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CP0073370
 Compound Info 
4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C25H30O2
  1
1
EC50 = 230 nM
 Bioactivity Info 
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CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
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C24H28O2
  2
1
EC50 = 282 nM
 Bioactivity Info 
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2
EC50 > 10000 nM
 Bioactivity Info 
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CP0150625
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
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C23H30O2
  1
1
EC50 = 287 nM
 Bioactivity Info 
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CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O2
  1
1
EC50 = 304 nM
 Bioactivity Info 
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CP0061828
 Compound Info 
4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
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C26H32O2
  1
1
EC50 = 310 nM
 Bioactivity Info 
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CP0377756
 Compound Info 
4-[(E)-2-(3,3-Dimethyl-2,3-dihydro-benzofuran-5-yl)-propenyl]-benzoic acid
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C20H20O3
  1
1
EC50 = 320 nM
 Bioactivity Info 
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CP0149843
 Compound Info 
4-[1-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25FO2
  1
1
EC50 = 337 nM
 Bioactivity Info 
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CP0059678
 Compound Info 
3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
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C25H32O2
  1
1
EC50 = 339 nM
 Bioactivity Info 
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CP0184156
 Compound Info 
4-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23FO3
  1
1
EC50 = 395 nM
 Bioactivity Info 
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CP0449634
 Compound Info 
4-[(E)-2-(3,3-Dimethyl-2,3-dihydro-benzofuran-5-yl)-propenyl]-benzoic acid methyl ester
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C21H22O3
  1
1
EC50 = 430 nM
 Bioactivity Info 
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CP0111163
 Compound Info 
4-[1-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25ClO2
  1
1
EC50 = 436 nM
 Bioactivity Info 
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CP0102521
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H34O2
  1
1
EC50 = 559 nM
 Bioactivity Info 
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CP0135295
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C25H34O2
  1
1
EC50 = 637 nM
 Bioactivity Info 
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CP0449565
 Compound Info 
(2E,4E,6E)-7-(3,3-Dimethyl-2,3-dihydro-benzofuran-5-yl)-3-methyl-octa-2,4,6-trienoic acid
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C19H22O3
  1
1
EC50 = 770 nM
 Bioactivity Info 
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CP0092680
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 809 nM
 Bioactivity Info 
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CP0059698
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
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C26H36O2
  1
1
EC50 = 809 nM
 Bioactivity Info 
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CP0372864
 Compound Info 
(2E,4E,6E)-7-(3,3-Dimethyl-2,3-dihydro-benzo[b]thiophen-5-yl)-3-methyl-octa-2,4,6-trienoic acid
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C19H22O2S
  1
1
EC50 = 1200 nM
 Bioactivity Info 
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CP0049287
 Compound Info 
4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O3
  1
1
EC50 = 1388 nM
 Bioactivity Info 
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CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O3
  2
1
EC50 = 2068 nM
 Bioactivity Info 
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2
EC50 > 10000 nM
 Bioactivity Info 
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CP0100503
 Compound Info 
4-[1-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H26O3
  1
1
EC50 = 2238 nM
 Bioactivity Info 
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CP0041092
 Compound Info 
4-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H24O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0063697
 Compound Info 
4-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C24H28O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0063793
 Compound Info 
4-[1-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C26H32O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0063958
 Compound Info 
4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C23H25BrO2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0076318
 Compound Info 
4-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0100726
 Compound Info 
4-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C25H30O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0105911
 Compound Info 
4-[1-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C24H28O3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0123457
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C26H32O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0144133
 Compound Info 
4-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23ClO3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0149955
 Compound Info 
4-[1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
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C25H30O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0186182
 Compound Info 
4-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C22H23BrO3
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0209249
 Compound Info 
4-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
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C23H26O4
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0148476
 Compound Info 
4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C27H34O2
  1
1
EC50 > 10000 nM
 Bioactivity Info 
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CP0134367
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
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CP0215028
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0280492
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1
EC50 > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0122733
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1
Kd > 1000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0384182
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-3',5'-difluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C26H26F4O3
  1
1
Ki = 1956 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0465377
 Compound Info 
(2E,4E,6Z)-7-(3-Isopropyl-5-pentafluoroethyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C23H27F5O3
  1
1
Ki = 1984 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377464
 Compound Info 
(2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-3-isopropyl-5-thiophen-2-yl-phenyl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C24H26F2O3S
  1
1
Ki = 2112 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0448038
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C26H27F3O3
  1
1
Ki = 2112 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0403927
 Compound Info 
(2E,4E,6Z)-7-(2-Butoxy-3-isopropyl-5-pentafluoroethyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C24H29F5O3
  1
1
Ki = 2270 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0406456
 Compound Info 
(2E,4E,6Z)-7-[2-(2,2-Difluoro-ethoxy)-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C26H28F2O3
  1
1
Ki = 2612 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0377687
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-3'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C26H27F3O3
  1
1
Ki = 3597 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0420322
 Compound Info 
(2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-2'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C26H27F3O3
  1
1
Ki = 3927 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0395224
 Compound Info 
(2E,4E,6E)-7-(2-Butoxy-3,5-diisopropyl-phenyl)-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H35FO3
  1
1
Ki = 4623 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0401559
 Compound Info 
(2E,4E,6E)-7-[2-(2,2-Difluoro-ethoxy)-3,5-bis-(1,1-dimethyl-propyl)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C27H37F3O3
  1
1
Ki = 5325 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0004953
 Compound Info 
(2E,4E,6E)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H33F3O3
  1
1
Ki = 5681 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397600
 Compound Info 
(2E,4E,6E)-7-[3,5-Di-tert-butyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-6-fluoro-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H32F4O3
  1
1
Ki = 6008 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0006755
 Compound Info 
(2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H34F2O3
  1
1
Ki = 9513 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0044243
 Compound Info 
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID
   Show/Hide
C24H29NO2
  1
1
Ki = 9901 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0394545
 Compound Info 
(2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroethyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C22H25F5O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0397602
 Compound Info 
(2E,4E,6Z)-7-(5-Isopropyl-3-pentafluoroethyl-2-propoxy-phenyl)-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C23H27F5O3
  1
1
Ki > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000026 , CHO-K1
 Cell Line Info 
Cell Line ID: CL000053 , COS-7
 Cell Line Info 
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Cell Line ID: CL000017 , HeLa
 Cell Line Info 
Cell Line ID: CL000789 , HG5LN
 Cell Line Info 
Cell Line ID: CL000035 , NIH 3T3
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0040160
 Compound Info 
9-cis-retinoic acid (9cRA)
   Show/Hide
C20H28O2
  18
1 EC50 = 1.5 nM
2 EC50 = 12 nM
3 EC50 = 17.6 nM
4 EC50 = 38 nM
5 EC50 = 80 nM
6 IC50 = 0.9 nM
7 IC50 = 0.94 nM
8 IC50 = 13 nM
9 IC50 = 3000 nM
10 Kd = 7 nM
11 Kd = 11 nM
12 Kd = 12 nM
13 Kd = 13 nM
14 Kd = 17 nM
15 Ki = 0.4 nM
16 Ki = 0.5 nM
17 Ki = 7 nM
18 Ki = 17.4 nM
CP0041093
 Compound Info 
(E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzoic acid
   Show/Hide
C24H28O2
  7
1 EC50 = 3 nM
2 EC50 = 4 nM
3 EC50 = 6 nM
4 IC50 = 5 nM
5 Kd = 5 nM
6 Ki = 0.5 nM
7 Ki = 5 nM
CP0042977
 Compound Info 
9-cis retinoic acid
   Show/Hide
C20H28O2
  10
1 EC50 = 3.3 nM
2 EC50 = 22 nM
3 EC50 = 50 nM
4 IC50 = 7 nM
5 Kd = 7 nM
6 Kd = 97 nM
7 Kd = 100 nM
8 Ki = 0.5 nM
9 Ki = 0.7 nM
10 Ki = 10.9 nM
CP0096948
 Compound Info 
4-[4-(2-ethoxyethoxy)-5-methyl-1,3-thiazol-2-yl]benzoic acid
   Show/Hide
C15H17NO4S
  1
1 EC50 = 56.7 nM
CP0073370
 Compound Info 
4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C25H30O2
  2
1 EC50 = 74 nM
2 IC50 = 1169 nM
CP0061828
 Compound Info 
4-[(E)-2-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C26H32O2
  2
1 EC50 = 961 nM
2 IC50 = 75 nM
CP0099526
 Compound Info 
AC-55649
   Show/Hide
C21H26O2
  1
1 EC50 = 6900 nM
CP0374363
 Compound Info 
4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]benzoic acid
   Show/Hide
C17H21NO4S
  1
1 EC50 = 8000 nM
CP0004259
 Compound Info 
4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
   Show/Hide
C24H28O2
  7
1 EC50 > 10000 nM
2 Kd > 1000 nM
3 Ki = 50 nM
4 Ki = 5353 nM
5 Ki > 550 nM
6 Ki > 800 nM
7 Ki > 1000 nM
CP0148476
 Compound Info 
4-[(E)-2-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-benzoic acid
   Show/Hide
C27H34O2
  1
1 IC50 = 150 nM
CP0206520
 Compound Info 
4-(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthalen-2-ylethynyl)-benzoic acid
   Show/Hide
C25H20O2S
  1
1 Kd = 20 nM
CP0297336
 Compound Info 
5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthalene-2-carboxylic acid 4-carboxy-phenyl ester
   Show/Hide
C24H20O4S
  1
1 Kd = 189 nM
CP0042976
 Compound Info 
(2E,4E)-3-Methyl-6-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-hexa-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 463 nM
CP0047977
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H26O2
  2
1 Kd = 909 nM
2 Ki = 909 nM
CP0272616
 Compound Info 
4-[(5,5-Dimethyl-8-thiophen-2-yl-5,6-dihydro-naphthalene-2-carbonyl)-amino]-benzoic acid
   Show/Hide
C24H21NO3S
  1
1 Kd = 996 nM
CP0076822
 Compound Info 
4-(1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene-7-carboxamido)benzoic acid
   Show/Hide
C22H25NO3
  2
1 Kd = 1361 nM
2 Kd = 1400 nM
CP0103897
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 6200 nM
CP0095234
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd = 20500 nM
CP0041092
 Compound Info 
4-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H24O4
  1
1 Kd > 1000 nM
CP0049287
 Compound Info 
4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H24O3
  1
1 Kd > 1000 nM
CP0063697
 Compound Info 
4-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C24H28O3
  1
1 Kd > 1000 nM
CP0063793
 Compound Info 
4-[1-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C26H32O2
  1
1 Kd > 1000 nM
CP0063958
 Compound Info 
4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H25BrO2
  1
1 Kd > 1000 nM
CP0076318
 Compound Info 
4-(3-Isopropyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C25H30O3
  1
1 Kd > 1000 nM
CP0092667
 Compound Info 
4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C23H26O3
  2
1 Kd > 1000 nM
2 Ki > 10000 nM
CP0100503
 Compound Info 
4-[1-(3-Hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H26O3
  1
1 Kd > 1000 nM
CP0100726
 Compound Info 
4-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C25H30O3
  1
1 Kd > 1000 nM
CP0105911
 Compound Info 
4-[1-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C24H28O3
  1
1 Kd > 1000 nM
CP0111163
 Compound Info 
4-[1-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H25ClO2
  1
1 Kd > 1000 nM
CP0123457
 Compound Info 
4-[1-(5,5,8,8-Tetramethyl-3-propyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C26H32O2
  1
1 Kd > 1000 nM
CP0144133
 Compound Info 
4-(3-Chloro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H23ClO3
  1
1 Kd > 1000 nM
CP0149843
 Compound Info 
4-[1-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C23H25FO2
  1
1 Kd > 1000 nM
CP0149955
 Compound Info 
4-[1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
   Show/Hide
C25H30O2
  1
1 Kd > 1000 nM
CP0184156
 Compound Info 
4-(3-Fluoro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H23FO3
  1
1 Kd > 1000 nM
CP0186182
 Compound Info 
4-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C22H23BrO3
  1
1 Kd > 1000 nM
CP0209249
 Compound Info 
4-(3-Methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-benzoic acid
   Show/Hide
C23H26O4
  1
1 Kd > 1000 nM
CP0134367
 Compound Info 
(E)-3-Methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Kd > 1000 nM
CP0215028
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
   Show/Hide
C24H32O2
  1
1 Kd > 1000 nM
CP0280492
 Compound Info 
(2Z,4E)-3-methyl-5-[2-methyl-2-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Kd > 1000 nM
CP0063990
 Compound Info 
(2E,4E)-6-[1-(3,5-Di-tert-butyl-phenyl)-cyclopropyl]-3-methyl-hexa-2,4-dienoic acid
   Show/Hide
C24H34O2
  1
1 Kd > 1000 nM
CP0042771
 Compound Info 
5',5',8',8'-Tetramethyl-5',6',7',8'-tetrahydro-[2,2']binaphthalenyl-6-carboxylic acid
   Show/Hide
C25H26O2
  1
1 Ki = 13 nM
CP0076073
 Compound Info 
6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid
   Show/Hide
C28H28O3
  1
1 Ki = 34 nM
CP0047520
 Compound Info 
6-(3-Adamantan-1-yl-4-hydroxy-phenyl)-naphthalene-2-carboxylic acid
   Show/Hide
C27H26O3
  1
1 Ki = 2480 nM
CP0006755
 Compound Info 
(2E,4E,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-3-methyl-octa-2,4,6-trienoic acid
   Show/Hide
C25H34F2O3
  1
1 Ki = 4687 nM
CP0092680
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Ki > 1000 nM
CP0150625
 Compound Info 
(2E,4E)-3-Methyl-5-[1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-penta-2,4-dienoic acid
   Show/Hide
C23H30O2
  1
1 Ki > 1000 nM
CP0044243
 Compound Info 
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID
   Show/Hide
C24H29NO2
  1
1 Ki > 1000 nM
CP0059678
 Compound Info 
3-Methyl-5-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopent-1-enyl]-penta-2,4-dienoic acid
   Show/Hide
C25H32O2
  1
1 Ki > 1000 nM
CP0059698
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2R)-1-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H36O2
  1
1 Ki > 1000 nM
CP0102521
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-4-methylene-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C26H34O2
  1
1 Ki > 1000 nM
CP0135295
 Compound Info 
(2E,4E)-3-Methyl-5-[(1R,2S)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopentyl]-penta-2,4-dienoic acid
   Show/Hide
C25H34O2
  1
1 Ki > 1000 nM
Clinical Information about the Protein
Target 1 ( Retinoic acid receptor beta (RARB) )
Target Type Successful Target
Disease 2 Target-related Diseases  2
1 Kaposi sarcoma [ICD-11: 2B57]
2 T-cell leukaemia [ICD-11: 2A90]
Approved Drug(s) 1 Approved Drug  1
1 Alitretinoin
 Drug Info 
Approved
Kaposi sarcoma
Clinical Trial Drug(s) 1 Clinical Trial Drug  1
1 Tamibarotene
 Drug Info 
Phase 3
T-cell leukaemia
Similar Protein(s) and Bioactivity Statistics
50% Identity
Protein ID Protein Name Protein Organism
PT01475 Retinoic acid receptor alpha Homo sapiens, Human
 Protein Info 
PT01621 Retinoic acid receptor alpha Mus musculus, Mouse
 Protein Info